Recent toxicological investigations of metal or metal oxide nanoparticles in mammalian models in vitro and in vivo: DNA damaging potential, and relevant physicochemical characteristics

2014 ◽  
Vol 10 (2) ◽  
pp. 107-126 ◽  
Author(s):  
Preeyaporn Koedrith ◽  
Rattana Boonprasert ◽  
Jee Young Kwon ◽  
Im-Soon Kim ◽  
Young Rok Seo
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Physicochemical Characteristics ◽  
Oxide Nanoparticles

scholarly journals The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

2021 ◽  
Vol 394 (10) ◽  
pp. 1991-2002
Author(s):  
Junchao Luo ◽  
Yin Zhang ◽  
Senbo Zhu ◽  
Yu Tong ◽  
Lichen Ji ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Biological Response ◽  
Cell Uptake ◽  
Oxide Nanoparticles ◽  
Therapeutic Effects ◽  
Superoxide Anions ◽  
Metal Metal ◽  
Cartilage Wear

AbstractThe current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

In vitro evaluation of cytotoxicity of engineered metal oxide nanoparticles

2009 ◽  
Vol 407 (8) ◽  
pp. 3070-3072 ◽  
Author(s):  
Xiaoke Hu ◽  
Sean Cook ◽  
Peng Wang ◽  
Huey-min Hwang
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
In Vitro Evaluation

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

The Analyst ◽  
2012 ◽  
Vol 137 (21) ◽  
pp. 4902 ◽  
Author(s):  
Carlos Pérez-Campaña ◽  
Vanessa Gómez-Vallejo ◽  
Abraham Martin ◽  
Eneko San Sebastián ◽  
Sergio E. Moya ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Proton Beam ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
General Synthesis

scholarly journals Dendrimer Functionalized Metal Oxide Nanoparticle mediated Self-Assembled Collagen Scaffold for Skin Regenerative Application: Function of Metal in Metal oxides

2021 ◽  
Author(s):  
KJ Sree ◽  
Mohan Vedhanayagam ◽  
Balachandran Unni Nair ◽  
Anandasadagopan Suresh kumar
Keyword(s):  
Metal Oxide ◽  
Mechanical Strength ◽  
Cell Viability ◽  
Metal Oxide Nanoparticles ◽  
Collagen Scaffold ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
Collagen Scaffolds ◽  
Assembly Method

Abstract Functionalized metal oxide nanoparticles cross-linked collagen scaffolds are widely used in skin regenerative applications because of their enhanced physico-chemical and biocompatibility properties. From the safety clinical trials point of view, there are no reports that have compared the effects of functionalized metal oxide nanoparticles mediated collagen scaffolds for in-vivo skin regenerative applications. In this work, Triethoxysilane - Poly (amido amine) dendrimer generation 3 (TES-PAMAM -G3 or G3) functionalized spherical shape metal oxide nanoparticles (MO NPs: ZnO, TiO2, Fe3O4, CeO2, and SiO2, Size: 12 -25 nm) cross-linked collagen scaffolds were prepared by using a self-assembly method. Triple helical conformation, pore size, mechanical strength and in-vitro cell viability of MO-TES-PAMAM-G3- collagen scaffolds were studied through different methods. The in-vivo skin regenerative proficiency of MO-TES-PAMAM-G3- collagen scaffolds were analysed by implanting the scaffold on wounds in Wistar Albino rats. The results demonstrated that MO-TES-PAMAM-G3- collagen scaffold showed superior skin regeneration properties than other scaffolds. The skin regenerative efficiency of MO NPs followed order: ZnO> TiO2> CeO2> SiO2> Fe3O4 NPs. This result can be attributed to higher mechanical strength, cell –viability and better antibacterial activity of ZnO-TES-PAMAM-G3-collagen scaffold lead to accelerate the skin regenerative properties in comparison to other metal oxide based collagen scaffolds.

scholarly journals Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization

2021 ◽  
Vol 12 ◽  
Author(s):  
Sung-Hyun Kim ◽  
Jin Hee Lee ◽  
Kikyung Jung ◽  
Jun-Young Yang ◽  
Hyo-Sook Shin ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Ion ◽  
Metal Oxide Nanoparticles ◽  
Skin Sensitization ◽  
Ion Release ◽  
Metal Chlorides ◽  
Cobalt Ions ◽  
Metal Ion Release

Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to nanomaterials. In this study, we evaluated the skin sensitization of nanomaterials comparing metal haptens in vivo and in vitro. We selected five metal oxide NPs, containing copper oxide, cobalt monoxide, cobalt oxide, nickel oxide, or titanium oxide, and two types of metal chlorides (CoCl2 and CuCl2), to compare the skin sensitization abilities between NPs and the constituent metals. The materials were applied to KeratinoSensTM cells for imitated skin-environment setting, and luciferase induction and cytotoxicity were evaluated at 48 h post-incubation. In addition, the response of metal oxide NPs was confirmed in lymph node of BALB/C mice via an in vivo method. The results showed that CuO and CoO NPs induce a similar pattern of positive luciferase induction and cytotoxicity compared to the respective metal chlorides; Co3O4, NiO, and TiO2 induced no such response. Collectively, the results implied fast-dissolving metal oxide (CuO and CoO) NPs release their metal ion, inducing skin sensitization. However, further investigations are required to elucidate the mechanism underlying NP-induced skin sensitization. Based on ion chelation data, metal ion release was confirmed as the major “factor” for skin sensitization.

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