scholarly journals Dendrimer Functionalized Metal Oxide Nanoparticle mediated Self-Assembled Collagen Scaffold for Skin Regenerative Application: Function of Metal in Metal oxides

2021 ◽  
Author(s):  
KJ Sree ◽  
Mohan Vedhanayagam ◽  
Balachandran Unni Nair ◽  
Anandasadagopan Suresh kumar
Keyword(s):  
Metal Oxide ◽  
Mechanical Strength ◽  
Cell Viability ◽  
Metal Oxide Nanoparticles ◽  
Collagen Scaffold ◽  
Albino Rats ◽  
Oxide Nanoparticles ◽  
Collagen Scaffolds ◽  
Assembly Method

Abstract Functionalized metal oxide nanoparticles cross-linked collagen scaffolds are widely used in skin regenerative applications because of their enhanced physico-chemical and biocompatibility properties. From the safety clinical trials point of view, there are no reports that have compared the effects of functionalized metal oxide nanoparticles mediated collagen scaffolds for in-vivo skin regenerative applications. In this work, Triethoxysilane - Poly (amido amine) dendrimer generation 3 (TES-PAMAM -G3 or G3) functionalized spherical shape metal oxide nanoparticles (MO NPs: ZnO, TiO2, Fe3O4, CeO2, and SiO2, Size: 12 -25 nm) cross-linked collagen scaffolds were prepared by using a self-assembly method. Triple helical conformation, pore size, mechanical strength and in-vitro cell viability of MO-TES-PAMAM-G3- collagen scaffolds were studied through different methods. The in-vivo skin regenerative proficiency of MO-TES-PAMAM-G3- collagen scaffolds were analysed by implanting the scaffold on wounds in Wistar Albino rats. The results demonstrated that MO-TES-PAMAM-G3- collagen scaffold showed superior skin regeneration properties than other scaffolds. The skin regenerative efficiency of MO NPs followed order: ZnO> TiO2> CeO2> SiO2> Fe3O4 NPs. This result can be attributed to higher mechanical strength, cell –viability and better antibacterial activity of ZnO-TES-PAMAM-G3-collagen scaffold lead to accelerate the skin regenerative properties in comparison to other metal oxide based collagen scaffolds.

scholarly journals The application prospect of metal/metal oxide nanoparticles in the treatment of osteoarthritis

2021 ◽  
Vol 394 (10) ◽  
pp. 1991-2002
Author(s):  
Junchao Luo ◽  
Yin Zhang ◽  
Senbo Zhu ◽  
Yu Tong ◽  
Lichen Ji ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Biological Response ◽  
Cell Uptake ◽  
Oxide Nanoparticles ◽  
Therapeutic Effects ◽  
Superoxide Anions ◽  
Metal Metal ◽  
Cartilage Wear

AbstractThe current understanding of osteoarthritis is developing from a mechanical disease caused by cartilage wear to a complex biological response involving inflammation, oxidative stress and other aspects. Nanoparticles are widely used in drug delivery due to its good stability in vivo and cell uptake efficiency. In addition to the above advantages, metal/metal oxide NPs, such as cerium oxide and manganese dioxide, can also simulate the activity of antioxidant enzymes and catalyze the degradation of superoxide anions and hydrogen peroxide. Degrading of metal/metal oxide nanoparticles releases metal ions, which may slow down the progression of osteoarthritis by inhibiting inflammation, promoting cartilage repair and inhibiting cartilage ossification. In present review, we focused on recent research works concerning osteoarthritis treating with metal/metal oxide nanoparticles, and introduced some potential nanoparticles that may have therapeutic effects.

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

The Analyst ◽  
2012 ◽  
Vol 137 (21) ◽  
pp. 4902 ◽  
Author(s):  
Carlos Pérez-Campaña ◽  
Vanessa Gómez-Vallejo ◽  
Abraham Martin ◽  
Eneko San Sebastián ◽  
Sergio E. Moya ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Proton Beam ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
General Synthesis

scholarly journals Observations of in vivo Processing of Metal Oxide Nanoparticles by Analytical TEM/STEM

2015 ◽  
Vol 21 (S3) ◽  
pp. 2287-2288 ◽  
Author(s):  
Uschi M. Graham ◽  
Alan K. Dozier ◽  
Giinter Oberdorster ◽  
Chen Wang ◽  
Michael T. Tseng ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Analytical Tem

scholarly journals Mitigating effect of organic matter on the in vivo toxicity of metal oxide nanoparticles in the marine environment

2018 ◽  
Vol 5 (7) ◽  
pp. 1764-1777 ◽  
Author(s):  
Seta Noventa ◽  
Darren Rowe ◽  
Tamara Galloway
Keyword(s):  
Organic Matter ◽  
Metal Oxide ◽  
Marine Environment ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
In Vivo Toxicity

We investigate the effectiveness of two promising paradigms (i.e. dissolution and bandgap) to predict the toxicity of metal oxide nanoparticles (NPs) in vivo and under seawater conditions.

scholarly journals Novel lanthanide-labeled metal oxide nanoparticles improve the measurement of in vivo clearance and translocation

2013 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Aamir D Abid ◽  
Donald S Anderson ◽  
Gautom K Das ◽  
Laura S Van Winkle ◽  
Ian M Kennedy
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Materials and toxicological approaches to study metal and metal-oxide nanoparticles in the model organism Caenorhabditis elegans

2017 ◽  
Vol 4 (5) ◽  
pp. 719-746 ◽  
Author(s):  
Laura Gonzalez-Moragas ◽  
Laura L. Maurer ◽  
Victoria M. Harms ◽  
Joel N. Meyer ◽  
Anna Laromaine ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Model Organism ◽  
Oxide Nanoparticles ◽  
C Elegans ◽  
Biological Responses ◽  
Approaches To Study

The C. elegans biological responses to metal-based nanoparticles are reviewed. A cross-disciplinary workflow for nanoparticles screening in vivo is proposed.

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