The immune response in the CNS in Theiler’s virus induced demyelinating disease switches from an early adaptive response to a chronic innate-like response

Abstract Theiler's murine encephalomyelitis virus causes a chronic demyelinating disease in susceptible strains of mice that is similar to human multiple sclerosis. Several nonmajor histocompatibility complex–linked genes have been implicated as determinants of susceptibility or resistance to either demyelination or virus persistence. In this study, we used linkage analysis of major histocompatibility complex identical H-2d (DBA/2J × B10.D2) F2 intercross mice to identify loci associated with susceptibility to virus-induced demyelinating disease. In a 20-cM region on chromosome 14, we identified four markers, D14Mit54, D14Mit60, D14Mit61, and D14Mit90 that are significantly associated with demyelination. Because two peaks were identified, one near D14Mit54 and one near D14Mit90, it is possible that two loci in this region are involved in controlling demyelination.

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Still’s Disease in the Constellation of Hyperinflammatory Syndromes: A Link with Kawasaki Disease?

Journal of Clinical Medicine ◽

10.3390/jcm10153244 ◽

2021 ◽

Vol 10 (15) ◽

pp. 3244

Author(s):

Perrine Dusser ◽

Isabelle Koné-Paut

Keyword(s):

Immune Response ◽

Kawasaki Disease ◽

Innate Immune Response ◽

Adaptive Response ◽

Genetic Factors ◽

Innate Immune ◽

Cytokine Storm ◽

Still’S Disease ◽

Still's Disease ◽

Excessive Activation

Still’s disease and Kawasaki disease (KD) today belong to the group of cytokine storm syndromes, a pathophysiological set related to excessive activation of the innate immune response. We present here a personal vision of what can link these two diseases, taking up their concepts at their beginning. By their many clinical and physiopathological similarities, we conclude that they constitute a common spectrum whose fate is modified by subtle differences in terms of adaptive response that could, in part, be driven by genetic factors.

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Theiler’s Virus-Induced Demyelinating Disease in Mice

Infectious Agents and Pathogenesis - Neuropathogenic Viruses and Immunity ◽

10.1007/978-1-4684-5886-2_5 ◽

1992 ◽

pp. 79-91

Author(s):

Howard L. Lipton ◽

Mauro C. dal Canto

Keyword(s):

Demyelinating Disease ◽

Theiler's Virus

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Pathogenic Immunity in Theiler’s Virus-Induced Demyelinating Disease: A Viral Model for Multiple Sclerosis

Autoimmunity ◽

10.1007/978-94-010-0981-2_7 ◽

2001 ◽

pp. 83-94

Author(s):

Byung S. Kim ◽

Joann P. Palma ◽

Atsushi Inoue ◽

Chang-Sung Koh

Keyword(s):

Multiple Sclerosis ◽

Demyelinating Disease ◽

Theiler's Virus

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Adaptive immunity

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.050103 ◽

2010 ◽

pp. 224-234

Author(s):

Paul Klenerman

Keyword(s):

Infectious Disease ◽

Immune Response ◽

Pattern Recognition ◽

Adaptive Immunity ◽

Adaptive Response ◽

Critical Role ◽

Adaptive Immune Response ◽

Structural Features ◽

Adaptive Immune ◽

Single Organism

Following the innate immune response, which acts very rapidly, the adaptive immune response plays a critical role in host defence against infectious disease. Unlike the innate response, which is triggered by pattern recognition of pathogens, i.e. features that are common to many bacteria or viruses, the adaptive response is triggered by structural features—known as antigens or epitopes—that are typically unique to a single organism....

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