scholarly journals Relationship of the balloon analog risk task to neurocognitive impairment differs by HIV serostatus and history of major depressive disorder

2022 ◽  
Author(s):  
Rowan Saloner ◽  
Erin E. Morgan ◽  
Mariam A. Hussain ◽  
David J. Moore ◽  
Robert K. Heaton ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Risk Behavior ◽  
Sexual Risk ◽  
Risk Behaviors ◽  
Sexual Risk Behavior ◽  
Risk Taking ◽  
Real World ◽  
Major Depressive ◽  
Hiv Serostatus

AbstractHIV and major depressive disorder (MDD) commonly co-occur and are both linked to greater risk-taking behavior, possibly due to neurocognitive impairment (NCI). The present study examined the concordance of the Balloon Analog Risk Task (BART), a gold standard measure of risk-taking propensity, with NCI and real-world sexual risk behaviors in PWH with comorbid MDD. Participants included 259 adults, stratified by HIV serostatus (HIV + /HIV −) and lifetime MDD (MDD + /MDD −), who completed neuropsychological testing, the BART, and sexual risk behavior questionnaires. Logistic regression, stratified by HIV serostatus, examined joint effects of MDD and BART (linear and quadratic) on NCI. Follow-up linear regressions examined sexual risk behavior and neurocognitive domain T-scores as correlates of the BART. NCI prevalence was lowest in HIV − /MDD − , but BART scores did not differ by HIV/MDD status. In the HIV + group, BART performance predicted NCI such that high and low BART scores related to greater odds of NCI, but only in dual-risk HIV + /MDD + individuals. HIV + /MDD + individuals with both low and high BART scores exhibited poorer learning and recall, whereas processing speed and executive function were only poor in low BART risk-taking HIV + /MDD + . Higher BART scores linearly related to higher sexual risk behaviors only in MDD + individuals, independent of HIV serostatus. Low and high risk-taking on the BART may reflect discrete neurocognitive profiles in HIV + /MDD + individuals, with differential implications for real-world sexual risk behavior. HIV and comorbid MDD may disturb corticostriatal circuits responsible for integrating affective and neurocognitive components of decision-making, thereby contributing to risk-averse and risk-taking phenotypes.

scholarly journals Awareness, Gender Variations, Consequences of Sexual Risk Behavior and Adopted Solutions among Senior Secondary Schools Adolescents in Owerri, Nigeria.

2018 ◽  
Vol 5 (2) ◽  
pp. 50-58
Author(s):  
Chinomnso Nnebue ◽  
Chukwuma Duru ◽  
Stanley Onah ◽  
Kenechi Uwakwe ◽  
Achunam Nwabueze
Keyword(s):  
Risk Behavior ◽  
Sexual Risk ◽  
Risk Behaviors ◽  
Sex Education ◽  
Sexual Risk Behavior ◽  
Alcohol Intake ◽  
Sexual Risk Behaviors ◽  
School Type ◽  
Senior Secondary ◽  
Gender Variations

In our area, there is dearth of accurate sex education that could equip adolescents in making informed decisions on sexual issues. This scenario has been linked to a high prevalence of sexual risk behaviors, consequences and poor choices with regard to solutions. Objective: To determine the awareness, gender variations, consequences of sexual risk behavior, and adopted solutions among senior secondary school adolescents in Owerri, Nigeria. Methodology: This was a cross sectional survey of 384 in-school adolescents in Owerri, Nigeria, selected using a multistage sampling technique. Data were collected using pretested self-administered semi- structured questionnaires. Data were analyzed using SPSS v.22 (p<0.05). Results: The majority of adolescents, i.e. 306 (82.5%), were aware of sexual risk behaviors, 340 (91.6%) had received some sex education, and 296 (79.8%) were aware of contraceptives. Key sources of information on sexuality were schools and parents. In total, 54 (14.1%) participants were sexually active, 12 (22.2%) reported ever having an STI, and 9 (75%) had been treated in hospital. Also, 8 (14.8%) of the 54 had dealt with a pregnancy; 7 (87.5%) had undergone an abortion, 3 (42.9%) in a hospital. Sexual risk behaviors among males were associated with age (p=0.002), school type (p=0.002), and alcohol intake (p=0.000), while the residence of the parents had a stronger influence among females (p=0.014). Conclusions: This study found high awareness of sexual issues, mainly sourced from schools and parents. Associations were made between sexual risk behaviors and gender differences (age, school type, and alcohol intake in males, parental residence among females). The consequences of sexual risk behaviors were early pregnancy and STIs, with poor solutions adopted.

Major depressive disorder with subthreshold hypomanic (mixed) features: A real-world assessment of treatment patterns and economic burden

2017 ◽  
Vol 210 ◽  
pp. 332-337 ◽  
Author(s):  
Roger S. McIntyre ◽  
Daisy Ng-Mak ◽  
Chien-Chia Chuang ◽  
Rachel Halpern ◽  
Pankaj A. Patel ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Real World ◽  
Economic Burden ◽  
Treatment Patterns ◽  
Major Depressive ◽  
Mixed Features

Effect of agomelatine treatment on C-reactive protein levels in patients with major depressive disorder: an exploratory study in “real-world,” everyday clinical practice

CNS Spectrums ◽  
2016 ◽  
Vol 22 (4) ◽  
pp. 342-347 ◽  
Author(s):  
Domenico De Berardis ◽  
Michele Fornaro ◽  
Laura Orsolini ◽  
Felice Iasevoli ◽  
Carmine Tomasetti ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Clinical Practice ◽  
Depressive Symptoms ◽  
Depressive Disorder ◽  
Real World ◽  
Level Variation ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Everyday Clinical Practice ◽  
Reactive Protein

ObjectiveAgomelatine is a newer antidepressant but, to date, no studies have been carried out investigating its effects on C-reactive protein (CRP) levels in major depressive disorder (MDD) before and after treatment. The present study aimed (i) to investigate the effects of agomelatine treatment on CRP levels in a sample of patients with MDD and (ii) to investigate if CRP variations were correlated with clinical improvement in such patients.Methods30 adult outpatients (12 males, 18 females) with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) diagnosis of MDD were recruited in “real-world,” everyday clinical practice and treated with a flexible dose of agomelatine for 12 weeks. The Hamilton Rating Scale for Depression (HAM-D) and the Snaith-Hamilton Pleasure Scale (SHAPS) were used to evaluate depressive symptoms and anhedonia, respectively. Moreover, serum CRP was measured at baseline and after 12 weeks of treatment.ResultsAgomelatine was effective in the treatment of MDD, with a significant reduction in HAM-D and SHAPS scores from baseline to endpoint. CRP levels were reduced in the whole sample, with remitters showing a significant difference in CRP levels after 12 weeks of agomelatine. A multivariate stepwise linear regression analysis showed that higher CRP level variation was associated with higher baseline HAM-D scores, controlling for age, gender, smoking, BMI, and agomelatine dose.ConclusionsAgomelatine’s antidepressant properties were associated with a reduction in circulating CRP levels in MDD patients who achieved remission after 12 weeks of treatment. Moreover, more prominent CRP level variation was associated with more severe depressive symptoms at baseline.

scholarly journals Sex in the city

2019 ◽  
Vol 34 (2) ◽  
pp. 168-178
Author(s):  
Mathudara Phaiyarom ◽  
Montakarn Chuemchit
Keyword(s):  
Sexual Orientation ◽  
Sexual Harassment ◽  
Risk Behavior ◽  
Sexual Risk ◽  
Risk Behaviors ◽  
Sexual Risk Behavior ◽  
Demographic Data ◽  
Chiang Mai ◽  
Content Type ◽  
Sexual Activities

Purpose The purpose of this paper is to determine the sexual risk behavior and sexual harassment among female beer promoters in Chiang Mai, Thailand and analyze the associations among demographic data, sexual activities, sexual orientation, attitudes and working conditions based on the level of sexual harassment. Design/methodology/approach This study is a cross-sectional study that approached 184 Thai female beer promoters in Chiang Mai by a snowball sampling technique. Data were collected through a self-administrative questionnaire to find demographic data, sexual activities, sexual orientation, attitudes, sexual risk behavior and sexual harassment while working as a beer promoter. Descriptive, Pearson’s χ2 and Fisher exact tests were performed to describe and determine the associations. Findings The findings highlight that sexual risk behaviors and sexual harassment are found among female beer promoters. In total, 62.5 percent of them ever had sexual intercourse and 25.2 percent did not use condom. For sexual harassment, most of respondents had experienced a medium level harassment especially verbal harassment (73.9 percent). It associated with currently student status (p=0.038), having sexual intercourse experience (p=0.024), and type of job (p=0.002). Originality/value This paper explores the sexual risk behaviors and sexual harassment among female beer promoters in the northern part of Thailand, containing the information on how common are the types of sexual risk behavior and sexual harassment experiences among a specific and hard-to-reach population.

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