Controlling degradation rate of poly(lactic acid) for its biomedical applications

Abstract Poly-lactic acid based biocomposite strengthened with magnesium alloy wires (Mg wires/PLA composite) is prepared for bone fixation implantation. The influence of wire content and load mode on the degradation performances of the composite and its components is studied. The result suggests the degradation of Mg wires could slow down the pH decrease originated from the degradation of PLA, while a relatively high wire content contributes to descend the degradation rate of Mg wire in the composite. Dynamic load significantly promotes the mechanical loss of the specimens. After 30 days immersion, the Sb retention is about 65%, 52% and 55%, respectively for pure PLA, the composite at 10 vol% and 20 vol% under dynamic load, comparing to 75%, 70% and 72% under no load. Moreover, dynamic load could further mitigate the degradation of Mg wires by increasing convective transport of acidic products out of the composite.

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Effect of Block Length and Stereocomplexation on the Thermally Processable Poly(ε-caprolactone) and Poly(Lactic acid) Block Copolymers for Biomedical Applications

ACS Applied Polymer Materials ◽

10.1021/acsapm.9b00789 ◽

2019 ◽

Vol 1 (12) ◽

pp. 3354-3365

Author(s):

Neha Mulchandani ◽

Arvind Gupta ◽

Kazunari Masutani ◽

Sachin Kumar ◽

Shinichi Sakurai ◽

...

Keyword(s):

Lactic Acid ◽

Block Copolymers ◽

Biomedical Applications ◽

Block Length ◽

Poly Lactic Acid

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Modification of Poly(lactic acid) Films: Enhanced Wettability from Surface-Confined Photografting and Increased Degradation Rate Due to an Artifact of the Photografting Process

Macromolecules ◽

10.1021/ma049056u ◽

2004 ◽

Vol 37 (24) ◽

pp. 9151-9159 ◽

Cited By ~ 117

Author(s):

Amol V. Janorkar ◽

Andrew T. Metters ◽

Douglas E. Hirt

Keyword(s):

Lactic Acid ◽

Degradation Rate ◽

Poly Lactic Acid

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Base-Catalyzed Hydrolysis Behavior of PLA/PBS Blends

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.821-822.941 ◽

2013 ◽

Vol 821-822 ◽

pp. 941-944

Author(s):

Shi Jie Zhang ◽

Yi Wen Tang ◽

Li Hua Cheng

Keyword(s):

Molecular Weight ◽

Lactic Acid ◽

Degradation Rate ◽

Degradation Process ◽

Poly Lactic Acid ◽

Biodegradable Materials ◽

Butylene Succinate ◽

New Type

Poly (butylene succinate) (PBS) was mixed with Poly (lactic acid) (PLA) through Haake Reomix, a new type of biodegradable materials can be obtained. With the increasing addition of PBS and the raise of the solution basicity, the degradation rate of blends increase sharply. The GPC analysis can approve the reduction of molecular weight in the degradation process of PLA/PBS blends.

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Poly(lactic acid) blends in biomedical applications

Advanced Drug Delivery Reviews ◽

10.1016/j.addr.2016.06.014 ◽

2016 ◽

Vol 107 ◽

pp. 47-59 ◽

Cited By ~ 153

Author(s):

P. Saini ◽

M. Arora ◽

M.N.V. Ravi Kumar

Keyword(s):

Lactic Acid ◽

Biomedical Applications ◽

Poly Lactic Acid

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Biodegradable Mg Strengthened Poly-Lactic Acid Composite through Interfacial Properties

Materials Science Forum ◽

10.4028/www.scientific.net/msf.900.7 ◽

2017 ◽

Vol 900 ◽

pp. 7-11

Author(s):

Muhammad Shoaib Butt ◽

Jing Bai ◽

Feng Xue

Keyword(s):

Lactic Acid ◽

Body Fluid ◽

Biomedical Applications ◽

Mechanical Performance ◽

High Strength ◽

Poly Lactic Acid ◽

Magnesium Alloy Az31 ◽

Injection Process ◽

Good Potential ◽

Plastic Injection

High-strength magnesium alloy (AZ31) reinforced poly-lactic acid (PLA) composite rods for potential application of bone fracture fixation prepared by plastic injection process on Mg rod.Thecomposities possess improved the interfacial bonding between poly-lactic acid and Mg rod due to the micro-anchoring which lead to better mechanical performance in Simulated body fluid solution.The present results indicated that this new PLA-clad Mg composite rods show good potential for biomedical applications.

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