Protective effect of methanol leaf extract of Cnidoscolus aconitifolius against lipopolysaccharides-induced cortico-hippocampal neuroinflammation, oxidative stress and memory impairment

2021 ◽  
Author(s):  
Kabirat Temitope Babalola ◽  
Oyetola Oyebanjo ◽  
Victor Adetayo Adekoya ◽  
Ismaheel Akinwale Adeniyi ◽  
Abayomi Mayowa Ajayi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Memory Impairment ◽  
Leaf Extract ◽  
Cnidoscolus Aconitifolius

scholarly journals Toxicity evaluation and protective effect of Rhus longipes Engl. leaf extract in paracetamol induced oxidative stress in wister rats

2017 ◽  
Vol 6 (2) ◽  
pp. 73-77
Author(s):  
Olubukola S. Olorunnisola ◽  
◽  
Adewale Adetutu ◽  
Abiodun O. Owoade ◽  
Babatunde T. Adesina ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Effect ◽  
Leaf Extract ◽  
Control Group ◽  
P Value ◽  
Standard Drug ◽  
Test Of Significance ◽  
Dose Dependent ◽  
Isolated Liver

Aim: Acute toxicity and protective effect of ethanol leaf extract of Rhus longipes Engl. against Paracetamol induced oxidative stress was investigated. The LD50 of the leaf extract was determined using up and down technique and the effect of 1/10th and 1/20th/ LD50 of the extract on antioxidants enzymes and non-enzymes were assessed in the serum and isolated liver of normal and Paracetamol intoxicated rats. Data obtained were analyzed by one-way analysis of variance (ANOVA) and Dunnett’s t-test was used as the test of significance. Values were considered significant at P value < 0.05. The results obtained indicated that LD50 of Rhus longipes Engl. leaf extract is greater than 5000 mg/kg /body weight. A significant (p<0.05) increase was observed in the level of hepatic (H) TBARs (81.97%), Catalase (38.42%) and serum (S) TBARs (164.44%) and catalase (64.72%) respectively but, a significant (P<0.05) decrease in hepatic activities of SOD, GPX, GR, vitamin C and E in paracetamol treated groups when compared with the serum and normal control group respectively. The extracts (250 and 500 mg/kg/body/weight) and the standard silymarin significantly (p<0.05) restored the derange antioxidants parameters to near normal in dose dependent manners. The activities of the extract at the highest concentration (500 mg/kg/b.wt) compared favourably with the standard drug. The results suggested that the leaf extract of Rhus longipes Engl. contain bioactive compounds which could protect against toxicity induced oxidative stress. The results of this study can be used as a basis for further investigations in the search for the bioactive principle.

scholarly journals THE PROTECTIVE EFFECT OF MORINGA TEA AGAINST CYPERMETHRIN-INDUCED HEPATORENAL DYSFUNCTION, OXIDATIVE STRESS, AND HISTOPATHOLOGICAL ALTERATIONS IN FEMALE RATS

2018 ◽  
Vol 11 (10) ◽  
pp. 111
Author(s):  
Sameeh A Mansour ◽  
Reham I Mohamed ◽  
Amina R Ali ◽  
Abdel-razik H Farrag
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
High Elevation ◽  
Female Rats ◽  
Daily Consumption ◽  
Histopathological Alterations ◽  
Total Antioxidant ◽  
Positive Controls

Objectives: Exposure to α-cypermethrin (α-CP) may yield reactive oxygen species (ROS) that is responsible for oxidative stress in mammals. A variety of antioxidants were used to alleviate α-CP-induced toxicity in experimental animals. To the best of our knowledge, there are no attempts of using Moringa oleifera L. (MO) plant extracts against α-CP-induced toxicity. Therefore, this study was conducted.Methods: A total of 16 adult female rats were segregated into equally four groups: One group administered α-CP orally at a dose of 0.05/mg kg bw/ day; and the second group was freely allowed to drink MO leaf extract (moringa tea [MOT]) + the α-CP dose. The other two groups represented negative and positive controls. The daily consumption of the solutions was estimated. At the end of experiments (28 day), all animals were subjected to the planned manifestations.Results: MOT has proved its palatability as drinking solution more than water. Compared with control results, the relative weights of liver and brain recorded significant increases, while that of kidney, heart, spleen, ovary, and lung decreased significantly. Furthermore, alterations in the architecture of the liver, kidney, and brain were observed. α-CP treatment induced high elevation of the levels of aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, creatinine, and malondialdehyde, while caused decline of butyrylcholinesterase, urea, superoxide dismutase, and total antioxidant capacity levels. Coadministration of MOT restored biochemical and histopathological alterations caused by α-CP to a great extent.Conclusion: The present study introduces novel data on the protective effect of MO leaf extract against CP toxicity and sheds light on the palatability of “MOT” to rodents.

scholarly journals Protective Effect of Perilla Leaf Extract and its Constituents on t‐BHP‐induced Oxidative Stress in Liver

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Sung-Yong Yang ◽  
Chung-Oui Hong ◽  
Yun-Chang Koo ◽  
Mi-Hyun Nam ◽  
Kwang-Won Lee
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Leaf Extract

scholarly journals Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

2019 ◽  
Vol 8 (1) ◽  
pp. 64-68
Author(s):  
Pedram Moshaei-Nezhad ◽  
Seyed Mohammad Hosseini ◽  
Mohsen Yahyapour ◽  
Maryam Iman ◽  
Ali Khamesipour
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Leaf Extract

Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects

2021 ◽  
pp. 1-15
Author(s):  
Débora Batista ◽  
Jefferson Romáryo Duarte da Luz ◽  
Thayse Evellyn Silva Do Nascimento ◽  
Tiago Felipe de Senes-Lopes ◽  
Ony Araújo Galdino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Leaf Extract

Protective effect of raisin (currant) against spatial memory impairment and oxidative stress in Alzheimer disease model

2017 ◽  
Vol 22 (2) ◽  
pp. 110-118 ◽  
Author(s):  
Mohammad Gol ◽  
Davoud Ghorbanian ◽  
Nabiollah Soltanpour ◽  
Jamshid Faraji ◽  
Mohsen Pourghasem
Keyword(s):  
Oxidative Stress ◽  
Alzheimer Disease ◽  
Spatial Memory ◽  
Protective Effect ◽  
Memory Impairment ◽  
Disease Model ◽  
And Oxidative Stress
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