Solitary lower limb cutaneous metastasis in a case of esophageal adenocarcinoma: a rare presentation

Prostate cancer is the most common cancer affecting men in the United States and the second greatest cause of cancer-related death. Metastases usually occur to bone followed by distant lymph nodes and then viscera. Cutaneous metastases are extremely rare. Their presence indicates advanced disease and a poor prognosis. As they are highly variable in appearance and may mimic a more benign process, biopsy is essential for identification. Serine proteases, particularly human tissue kallikreins, may play an important role in promoting metastasis and facilitate infiltration of the skin. Individual cancer genetics may predispose to more aggressive cancer and thus earlier and more distant metastases. In this article, we report our case of a 67-year-old man with a 4-year history of castrate-resistant prostate cancer with cutaneous metastases confirmed by histology. Despite multiple lines of systemic therapy, the patient suffered progressive disease with worsening performance status and was enrolled in hospice.

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A case of acute limb ischemia

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20213719 ◽

2021 ◽

Vol 8 (10) ◽

pp. 1608

Author(s):

Kshiti Rai ◽

K. G. Sajeeth Kumar ◽

Danish Ekkalayil ◽

Anoop Chanthu K. K.

Keyword(s):

Acute Myeloid Leukemia ◽

Early Diagnosis ◽

Lower Limb ◽

Myeloid Leukemia ◽

Hematological Malignancy ◽

Limb Ischemia ◽

Acute Limb Ischemia ◽

Rare Presentation ◽

Hematological Evaluation ◽

Acute Myeloid

Thromboembolism is a well-recognized complication of hematological malignancy. The incidence of symptomatic thrombosis at diagnosis is relatively low in AML (acute myeloid leukemia) patients, though its incidence increases on treatment with anthracyclines. We reported a case of 69 year old female with T2DM who presented with DVT and later on acute limb ischemia of the same lower limb. On hematological evaluation, she had leukocytosis and thrombocytopenia. Further evaluation revealed AML. Thromboembolism as a rare presentation of AML in adults with leukemic hyperleukocytosis has seldom been reported. In the absence of clear guidelines, early diagnosis and management are desirable.

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Rare Presentation of Unilateral Weakness, Involuntary Movements and Ataxia with Subcortical T2 Hypointensity in a Diabetic Patient: A Case Report

Case Reports in Radiology ◽

10.1155/2012/768189 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3

Author(s):

Venkatraman Indiran ◽

Prabakaran Maduraimuthu

Keyword(s):

Case Report ◽

Diabetic Patient ◽

Upper Limb ◽

Lower Limb ◽

Early Identification ◽

Common Finding ◽

Rare Presentation ◽

Involuntary Movements ◽

Left Lower Limb ◽

Unilateral Weakness

Subcortical T2 hypointensity on MRI is not a common finding. We present a case of subcortical T2 hypointensity in a diabetic patient, who was referred with weakness of left lower limb and involuntary movements and ataxia of the left upper limb. Lab reports confirmed the diagnosis of nonketotic hyperglycemia. It is rather important to identify subcortical T2 hypointensity which has only been recently found to be associated with nonketotic hyperglycemia. Early identification and prompt correction of blood sugar would help in alleviating the neurological symptoms.

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