scholarly journals Constructing a knowledge-based heterogeneous information graph for medical health status classification

Author(s):  
Thuan Pham ◽  
Xiaohui Tao ◽  
Ji Zhang ◽  
Jianming Yong
2005 ◽  
Author(s):  
Saroj Saigal ◽  
P. Rosenbaum ◽  
B. Stoskopf ◽  
L. Hoult ◽  
W. Furlong ◽  
...  

BMJ Open ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. e022449
Author(s):  
Xinye Fang ◽  
Guannan Bai ◽  
Dafna A Windhorst ◽  
David Feeny ◽  
Saroj Saigal ◽  
...  

ObjectivesTo evaluate the feasibility, discriminant validity and concurrent validity of the Health Status Classification System-Preschool (HSCS-PS) in children aged 3 years in a large community sample in the Netherlands.Design/settingA prospective population-based cohort in Rotterdam, the Netherlands.ParticipantsA questionnaire was administrated to a sample of parents of 4546 children (36.7±1.5 months).Outcome measuresHealth-related quality of life (HRQOL) of children was measured by HSCS-PS. The HSCS-PS consists of 10 original domains. Two single-item measures of ‘General health’ and ‘Behavior’ were added. A disability score was calculated by summing up all 10 original domains to describe the overall health status. Feasibility was assessed by the response rate, percentages of missing answers, score distributions and the presence of floor/ceiling effects. Discriminant validity was analysed between subgroups with predefined conditions: low birth weight, preterm birth, wheezing, Ear-Nose-Throat surgical procedures and behaviour problems. In the absence of another HRQOL measure, this study uses the single-items ‘General health’ and ‘Behavior’ as a first step to evaluate concurrent validity of the HSCS-PS.ResultsFeasibility: response rate was 69%. Ceiling effects were observed in all domains. Discriminant validity: the disability score discriminated clearly between subgroups of children born with a ‘very low birth weight’, ‘very preterm birth’, with ‘four or more than four times wheezing’, ‘at least one ear-nose-throat surgical procedures’, ‘behaviour problems present’ and the ‘reference’ group. Concurrent validity: HSCS-PS domains correlated better with hypothesised parallel additional domains than with other non-hypothesised original domains.ConclusionsThis study supports the feasibility and validity of the HSCS-PS among preschoolers in community settings. We recommend developing a utility-based scoring algorithm for the HSCS-PS. Further empirical studies and repeated evaluations in varied populations are recommended.


1999 ◽  
Vol 52 (4) ◽  
pp. 293-301 ◽  
Author(s):  
Paul F.M. Krabbe ◽  
Marlies E.A. Stouthard ◽  
Marie-Louise Essink-Bot ◽  
Gouke J. Bonsel

Author(s):  
Christos Papadelis ◽  
Chrysoula Kourtidou-Papadeli ◽  
Fotini Lazaridou ◽  
Eleni Perantoni

Aviators engage in a variety of outdoor activities where their health status, the environment, and the degree of workload and fatigue affect their performance. An innovative tool has been developed, which supports the real-time health monitoring of pilots using new algorithms based on intelligent clustering techniques for the recognition of possible health problems in flight. The Smart Profiler and the Intelligent Advisor modules of this system exploit the use of knowledge based expert systems and intelligent classification techniques. Coupled with the Portal, which also exploits the use of intelligent clustering techniques, it estimates the pilot’s performance in unknown environments. The new system targets recognizing possible problems at the time of flying, but it can also be used for the monitoring of the pilot performance and progress throughout a period of time, as it stores information from different flying sessions. The system was applied in 20 private pilots during the flight of a Cessna 152 aerobatic. The device was reliable and user-friendly, enabling us to monitor real-time health status of aviators in order to detect possible problems caused by the actual environmental conditions to which individuals are exposed, thus contributing to their health and safety in their working environments. Despite the automation and increasing technological complexity of modern aircrafts, the human operator still plays an important role in controlling those demanding systems. Piloting an aircraft is a highly complex task that requires the pilot to be proficient in numerous skills (Wilson & Eggemeier, 1991) in a hostile environment of cabin pressure changes and circadian rhythm disturbances particularly in long duration flights. The resulting overload of the pilots mandates the need for real time health telemonitoring (Charles, Winget, Charles, De- Roshia, Markley, & Holley, 1984; Denison, Ledwith, & Poulton, 1966; U.S. National Research Council, 2002; Ustinaviciene, Obelenis, & Ereminas, 2004). Real time health telemonitoring would be crucial to early detect and prevent conditions affecting aviator’s vital signs and cognitive performance.


2012 ◽  
Vol 24 (10) ◽  
pp. 1561-1570 ◽  
Author(s):  
Jeannie-Marie S. Leoutsakos ◽  
Dingfen Han ◽  
Michelle M. Mielke ◽  
Sarah N. Forrester ◽  
JoAnn T. Tschanz ◽  
...  

ABSTRACTBackground: Several observational studies have suggested a link between health status and rate of decline among individuals with Alzheimer's disease (AD). We sought to quantify the relationship in a population-based study of incident AD, and to compare global comorbidity ratings to counts of comorbid conditions and medications as predictors of AD progression.Methods: This was a case-only cohort study arising from a population-based longitudinal study of memory and aging, in Cache County, Utah. Participants comprised 335 individuals with incident AD followed for up to 11 years. Patient descriptors included sex, age, education, dementia duration at baseline, and APOE genotype. Measures of health status made at each visit included the General Medical Health Rating (GMHR), number of comorbid medical conditions, and number of non-psychiatric medications. Dementia outcomes included the Mini-Mental State Examination (MMSE), Clinical Dementia Rating – sum of boxes (CDR-sb), and the Neuropsychiatric Inventory (NPI).Results: Health status tended to fluctuate over time within individuals. None of the baseline medical variables (GMHR, comorbidities, and non-psychiatric medications) was associated with differences in rates of decline in longitudinal linear mixed effects models. Over time, low GMHR ratings, but not comorbidities or medications, were associated with poorer outcomes (MMSE: β = –1.07 p = 0.01; CDR-sb: β = 1.79 p < 0.001; NPI: β = 4.57 p = 0.01).Conclusions: Given that time-varying GMHR, but not baseline GMHR, was associated with the outcomes, it seems likely that there is a dynamic relationship between medical and cognitive health. GMHR is a more sensitive measure of health than simple counts of comorbidities or medications. Since health status is a potentially modifiable risk factor, further study is warranted.


Medical Care ◽  
1996 ◽  
Vol 34 (7) ◽  
pp. 702-722 ◽  
Author(s):  
GEORGE W. TORRANCE ◽  
DAVID H. FEENY ◽  
WILLIAM J. FURLONG ◽  
RONALD D. BARR ◽  
YUEMING ZHANG ◽  
...  

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