COVID-19 diagnosis from chest x-rays: developing a simple, fast, and accurate neural network

Purpose Chest x-rays are a fast and inexpensive test that may potentially diagnose COVID-19, the disease caused by the novel coronavirus. However, chest imaging is not a first-line test for COVID-19 due to low diagnostic accuracy and confounding with other viral pneumonias. Recent research using deep learning may help overcome this issue as convolutional neural networks (CNNs) have demonstrated high accuracy of COVID-19 diagnosis at an early stage. Methods We used the COVID-19 Radiography database [36], which contains x-ray images of COVID-19, other viral pneumonia, and normal lungs. We developed a CNN in which we added a dense layer on top of a pre-trained baseline CNN (EfficientNetB0), and we trained, validated, and tested the model on 15,153 X-ray images. We used data augmentation to avoid overfitting and address class imbalance; we used fine-tuning to improve the model’s performance. From the external test dataset, we calculated the model’s accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1-score. Results Our model differentiated COVID-19 from normal lungs with 95% accuracy, 90% sensitivity, and 97% specificity; it differentiated COVID-19 from other viral pneumonia and normal lungs with 93% accuracy, 94% sensitivity, and 95% specificity. Conclusions Our parsimonious CNN shows that it is possible to differentiate COVID-19 from other viral pneumonia and normal lungs on x-ray images with high accuracy. Our method may assist clinicians with making more accurate diagnostic decisions and support chest X-rays as a valuable screening tool for the early, rapid diagnosis of COVID-19.

An algorithm for Parkinson’s disease speech classification based on isolated words analysis

Introduction Automatic assessment of speech impairment is a cutting edge topic in Parkinson’s disease (PD). Language disorders are known to occur several years earlier than typical motor symptoms, thus speech analysis may contribute to the early diagnosis of the disease. Moreover, the remote monitoring of dysphonia could allow achieving an effective follow-up of PD clinical condition, possibly performed in the home environment. Methods In this work, we performed a multi-level analysis, progressively combining features extracted from the entire signal, the voiced segments, and the on-set/off-set regions, leading to a total number of 126 features. Furthermore, we compared the performance of early and late feature fusion schemes, aiming to identify the best model configuration and taking advantage of having 25 isolated words pronounced by each subject. We employed data from the PC-GITA database (50 healthy controls and 50 PD patients) for validation and testing. Results We implemented an optimized k-Nearest Neighbours model for the binary classification of PD patients versus healthy controls. We achieved an accuracy of 99.4% in 10-fold cross-validation and 94.3% in testing on the PC-GITA database (average value of male and female subjects). Conclusion The promising performance yielded by our model confirms the feasibility of automatic assessment of PD using voice recordings. Moreover, a post-hoc analysis of the most relevant features discloses the option of voice processing using a simple smartphone application.

The development of a machine learning algorithm to identify occupational injuries in agriculture using pre-hospital care reports

Purpose Current injury surveillance efforts in agriculture are considerably hampered by the limited quantity of occupation or industry data in current health records. This has impeded efforts to develop more accurate injury burden estimates and has negatively impacted the prioritization of workplace health and safety in state and federal public health efforts. This paper describes the development of a Naïve Bayes machine learning algorithm to identify occupational injuries in agriculture using existing administrative data, specifically in pre-hospital care reports (PCR). Methods A Naïve Bayes machine learning algorithm was trained on PCR datasets from 2008–2010 from Maine and New Hampshire and tested on newer data from those states between 2011 and 2016. Further analyses were devoted to establishing the generalizability of the model across various states and various years. Dual visual inspection was used to verify the records subset by the algorithm. Results The Naïve Bayes machine learning algorithm reduced the volume of cases that required visual inspection by 69.5 percent over a keyword search strategy alone. Coders identified 341 true agricultural injury records (Case class = 1) (Maine 2011–2016, New Hampshire 2011–2015). In addition, there were 581 (Case class = 2 or 3) that were suspected to be agricultural acute/traumatic events, but lacked the necessary detail to make a certain distinction. Conclusions The application of the trained algorithm on newer data reduced the volume of records requiring visual inspection by two thirds over the previous keyword search strategy, making it a sustainable and cost-effective way to understand injury trends in agriculture.

ITEXT-BIO: Intelligent Term EXTraction for BIOmedical analysis

Here, we introduce ITEXT-BIO, an intelligent process for biomedical domain terminology extraction from textual documents and subsequent analysis. The proposed methodology consists of two complementary approaches, including free and driven term extraction. The first is based on term extraction with statistical measures, while the second considers morphosyntactic variation rules to extract term variants from the corpus. The combination of two term extraction and analysis strategies is the keystone of ITEXT-BIO. These include combined intra-corpus strategies that enable term extraction and analysis either from a single corpus (intra), or from corpora (inter). We assessed the two approaches, the corpus or corpora to be analysed and the type of statistical measures used. Our experimental findings revealed that the proposed methodology could be used: (1) to efficiently extract representative, discriminant and new terms from a given corpus or corpora, and (2) to provide quantitative and qualitative analyses on these terms regarding the study domain.