Resistance Exercise in Prostate Cancer Patients: a Short Review

Abstract Purpose of Review The aim of this paper is to provide an overview of recent findings concerning the utilization of resistance exercise (RE) in prostate cancer (PCa), in particular as pertaining to the management of cancer therapy side effects. Recent Findings As of late, studies investigating the effects of RE in PCa patients have found positive effects on muscle strength, body composition, physical functioning, quality of life, and fatigue. The combination of RE and impact training appears to decrease the loss of bone mineral density. RE seems to be well accepted and tolerated, even by patients with bone metastatic disease, although a modification of the RE prescription is often necessary. Summary In PCa patients, RE has been well-researched and the data are clear that it is beneficial in multiple ways. Future directions should look at the long-term effects of RE, including mortality and relapse, as well as implementation of exercise programs.

Download Full-text

Long-term Effects on Quality of Life After Treatment of Localized Prostate Cancer: A Comparison of 4 Different Treatment Modalities

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2012.07.1074 ◽

2012 ◽

Vol 84 (3) ◽

pp. S406

Author(s):

M. Hjalm-Eriksson ◽

A. Ullén ◽

J. Hugosson ◽

S. Nilsson ◽

B. Lennernäs ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Localized Prostate Cancer ◽

Treatment Modalities ◽

Long Term Effects

Download Full-text

No Long-term Effects of Hormonal Therapy Preceding Brachytherapy on Urinary Function and Health-related Quality of Life Among Prostate Cancer Patients

Urology ◽

10.1016/j.urology.2010.02.051 ◽

2010 ◽

Vol 76 (5) ◽

pp. 1150-1156 ◽

Cited By ~ 5

Author(s):

Judith Evers ◽

Nina Kupper ◽

Dionne Kessing ◽

Rob Davits ◽

Antoine Engelen ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Cancer Patients ◽

Health Related Quality ◽

Long Term Effects ◽

Urinary Function ◽

Related Quality ◽

Health Related

Download Full-text

Associations between single nucleotide polymorphisms (SNPs) in inflammation-related genes and quality of life after radiation therapy (RT) for prostate cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.6_suppl.2 ◽

2013 ◽

Vol 31 (6_suppl) ◽

pp. 2-2

Author(s):

Jonathan D. Schoenfeld ◽

Danielle Nina Margalit ◽

Irene M. Shui ◽

Julie L. Kasperzyk ◽

Howard D. Sesso ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Multiple Testing ◽

Health Study ◽

Candidate Snps ◽

Nucleotide Polymorphisms ◽

Long Term Effects ◽

Co Morbidity

2 Background: Prostate-directed RT results in local inflammation that may contribute to short-term toxicity and subsequently effects on long-term quality of life (QOL). We sought to explore the hypothesis that SNPs in inflammation-related genes may influence QOL sequelae following definitive prostate cancer RT. Methods: We studied Caucasian participants in the prospective US Physicians’ Health Study diagnosed and treated with RT for non-metastatic prostate cancer between 1982 and 2006. Forty-three SNPs in 10 inflammation-related genes were genotyped and analyzed using the additive model. Men were followed for cancer-specific QOL outcomes with regularly administered questionnaires. We dichotomized the maximum score for four parameters (decreased urinary stream, increased urinary frequency, rectal urgency and impotence) relevant to RT reported at least one year following RT and analyzed associations between scores and SNPs using Fisher’s exact tests and logistic regression. Results: We identified 264 men with QOL data who previously provided blood for genotype analysis and received RT at a median age of 72 years (IQR 68 – 76 years). Features at diagnosis included: 67% PSA<10, 61% Gleason<7, 95% T1/T2 disease and 71% Charlson co-morbidity index 0-1. QOL questions were completed a median of 6 years following RT. Without adjusting for multiple testing, 13 SNPs had nominally significant associations (p < 0.05) with QOL parameters; 7 remained significant after adjusting for age, features at diagnosis, and use of brachytherapy (Table). Conclusions: We identify candidate SNPs in inflammation-related genes that can be further explored in regards to their associations with long-term effects of prostate-directed RT. [Table: see text]

Download Full-text

Long-term Impact of Adenotonsillectomy on the Quality of Life of Children with Sleep-disordered breathing

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1709195 ◽

2020 ◽

Author(s):

Juliana Alves Sousa Caixeta ◽

Jessica Caixeta Silva Sampaio ◽

Vanessa Vaz Costa ◽

Isadora Milhomem Bruno da Silveira ◽

Carolina Ribeiro Fernandes de Oliveira ◽

...

Keyword(s):

Quality Of Life ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Sleep Disordered Breathing ◽

Long Term Effects ◽

Obstructive Sleep ◽

Long Term Impact ◽

Disordered Breathing

Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.

Download Full-text

Yoga therapy to reduce fatigue in cancer: effects of reminder e-mails and long-term efficacy

Supportive Care in Cancer ◽

10.1007/s00520-021-06345-z ◽

2021 ◽

Author(s):

Teresa Zetzl ◽

Andre Pittig ◽

Agnes Renner ◽

Birgitt van Oorschot ◽

Elisabeth Jentschke

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Mediation Model ◽

Long Term Effects ◽

Long Term Outcomes ◽

Cognitive Fatigue ◽

Yoga Therapy ◽

Life Data

Abstract Objective To examine the efficacy of reminder e-mails to continue yoga therapy on practice frequency and fatigue in cancer patients and long-term effects of yoga on fatigue, depression, and quality of life. Methodology One hundred two cancer patients who completed an 8-week yoga therapy were randomly allocated to two groups: reminder (N = 51) vs. no-reminder group (N = 51). After completing yoga therapy, the reminder group received weekly e-mails for 24 weeks, which reminded them of practicing yoga, whereas the no-reminder group did not. Primary outcomes were fatigue and practice frequency, and long-term outcomes were fatigue, depression, and quality of life. Data were assessed using questionnaires after yoga therapy (T1) and 6 months after completing yoga therapy (T2). Result A significantly stronger reduction of general (p = 0.038, d = 0.42) and emotional fatigue (p = 0.004, d = 0.59) and a higher increase of practice frequency (p = 0.015, d = 0.52) between T1 and T2 were found for the reminder group compared to the no-reminder group. In the mediation model, practice frequency as a mediator partially explained the changes in emotional fatigue (indirect effect B = − 0.10). Long-term effects of yoga therapy regarding fatigue, depression, and quality of life were found (F > 7.46, p < 0.001, d > 0.54). Conclusion Weekly reminder e-mails after yoga therapy can positively affect general and emotional fatigue and help cancer patients with fatigue establish a regular yoga practice at home. However, higher practice frequency did not lead to higher physical or cognitive fatigue improvement, suggesting other factors that mediate efficacy on physical or cognitive fatigue, such as mindfulness or side effects of therapy.

Download Full-text