Management and control of intraocular pressure applying macitentan hydrogel film formulation: improved effect of surfactant and cosurfactant system

2022 ◽  
Author(s):  
Sidhartha Sankar Hota ◽  
Souvik Nandi ◽  
Subrata Mallick
Keyword(s):  
Intraocular Pressure ◽  
Hydrogel Film ◽  
Film Formulation ◽  
And Control

scholarly journals Corneal Biomechanical Assessment Using Corneal Visualization Scheimpflug Technology in Keratoconic and Normal Eyes

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Lei Tian ◽  
Yi-Fei Huang ◽  
Li-Qiang Wang ◽  
Hua Bai ◽  
Qun Wang ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Corneal Thickness ◽  
Area Under The Curve ◽  
Biomechanical Properties ◽  
Corvis St ◽  
Biomechanical Assessment ◽  
Deformation Amplitude ◽  
Biomechanical Parameters ◽  
And Control ◽  
Corneal Biomechanical Properties

Purpose. To compare the corneal biomechanical properties of keratoconic patients and age-matched controls using corneal visualization Scheimpflug technology (Corvis ST).Methods. Sixty keratoconic eyes from 47 keratoconus patients and 60 normal eyes from 60 controls were enrolled in this prospective study. Tomography and biomechanical parameters of all eyes were obtained with the Pentacam and Corvis ST, respectively. Intraocular pressure was measured using a Goldmann applanation tonometer.Results.The tomography and biomechanical parameters of the keratoconic corneas were significantly different from those of the normal corneas except for the anterior chamber angle, first applanation length, the highest concavity time, and peak distance. The deformation amplitude was the best predictive parameter (area under the curve: 0.882), with a sensitivity of 81.7%, although there was a significant overlap between keratoconic and normal corneas that ranged from 1.0 to 1.4 mm. In both the keratoconus and control groups, the deformation amplitude was negatively correlated with intraocular pressure, central corneal thickness, and corneal volume at 3 and 5 mm.Conclusions. Corvis ST offers an alternative method for measuring corneal biomechanical properties. The possibility of classifying keratoconus based on deformation amplitude deserves clinical attention.

scholarly journals Ocular Rigidity and Outflow Facility in Nonproliferative Diabetic Retinopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Theonitsa Panagiotoglou ◽  
Miltiadis Tsilimbaris ◽  
Harilaos Ginis ◽  
Nikos Karyotakis ◽  
Vaggelis Georgiou ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Control Group ◽  
Diabetic Patients ◽  
Outflow Facility ◽  
Nonproliferative Diabetic Retinopathy ◽  
Computer Controlled ◽  
And Control

Purpose.To compare ocular rigidity (OR) and outflow facility (C) in patients with nonproliferative diabetic retinopathy (NPDR) and control subjects.Methods. Twenty-four patients with NPDR (NPDR group) and 24 controls (control group) undergoing cataract surgery were enrolled. NPDR group was further divided into patients with mild NPDR (NPDR1-group) and patients with moderate and/or severe NPDR (NPDR2-group). After cannulation of the anterior chamber, a computer-controlled device was used to infuse saline and increase the intraocular pressure (IOP) in a stepping procedure from 15 to 40 mmHg. Ocular rigidity and outflow facility coefficients were estimated from IOP and volume recordings.Results. Ocular rigidity was 0.0205 μL−1in NPDR group and 0.0202 μL−1in control group (P=0.942). In NPDR1-group, OR was 0.017 μL−1and in NPDR2-group it was 0.025μL−1(P=0.192). Outflow facility was 0.120 μL/min/mmHg in NPDR-group compared to 0.153 μL/min/mmHg in the control group at an IOP of 35 mmHg (P=0.151). There was no difference in C between NPDR1-group and NPDR2-group (P=0.709).Conclusions. No statistically significant differences in ocular rigidity and outflow facility could be documented between diabetic patients and controls. No difference in OR and C was detected between mild NPDR and severe NPDR.

The Evaluation of Central Corneal Thickness and Intraocular Pressure in Conjunction with Tear IGF-1 Levels in Patients with Acromegaly

2017 ◽  
Vol 27 (5) ◽  
pp. 531-534
Author(s):  
Emrah Kan ◽  
Elif K. Kan ◽  
Ali Okuyucu
Keyword(s):  
Intraocular Pressure ◽  
Central Corneal Thickness ◽  
Disease Duration ◽  
Corneal Thickness ◽  
Disease Status ◽  
Control Group ◽  
Significant Difference ◽  
Igf I ◽  
Duration Of Disease ◽  
And Control

Purpose To compare the central corneal thickness (CCT), intraocular pressure (IOP), and tear insulin-like growth factor 1 (IGF-1) levels between patients with acromegaly and a control group and to evaluate the possible effect of tear IGF-1 and duration of the disease on CCT and IOP. Methods We included 31 patients with acromegaly (study group) and 40 age- and sex-matched controls in the study. Patients with acromegaly were divided into 2 subgroups based on disease status (active/inactive). All participants underwent complete ophthalmologic evaluation including CCT and IOP values. Basal tear samples were collected from both groups and tear IGF-1 levels were measured. The CCT, IOP, and tear IGF-1 levels were compared between groups and subgroups and the association between tear IGF-I levels and ocular parameters (CCT, IOP) and disease duration were also evaluated. Results Central corneal thickness, IOP, and tear IGF-1 levels did not show a significant difference between study and control groups. We also did not find a significant difference in terms of CCT, IOP, or tear IGF-1 levels between subgroups of patients. Correlation analysis did not show an association between the duration of disease and tear IGF-1 levels with CCT or IOP. Conclusions There was no significant difference in tear IGF-1 levels between patients with acromegaly and controls. Additionally, there was no correlation between disease duration and tear IGF-1 levels with CCT or IOP levels. This lack of association may suggest that tear IGF-1 levels might not have an effect on CCT or IOP findings in patients with acromegaly.

scholarly journals Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

2021 ◽  
Vol 10 (20) ◽  
pp. 4700
Author(s):  
Javier Gene-Morales ◽  
Andrés Gené-Sampedro ◽  
Alba Martín-Portugués ◽  
Inmaculada Bueno-Gimeno
Keyword(s):  
Intraocular Pressure ◽  
Corneal Thickness ◽  
Training Session ◽  
Effect Sizes ◽  
Regression Analyses ◽  
Factors Associated ◽  
Before And After ◽  
Pressure Changes ◽  
And Control ◽  
Familiarization Session

To evaluate the effects of an acrobatic gymnastics (AG) training session on intraocular pressure (IOP), a familiarization session was employed to confirm the participant’s suitability for the study. Forty-nine gymnasts (63.27% females, 18–40 years old) voluntarily agreed to participate. As age, sex, baseline IOP, and central corneal thickness (CCT) were considered as potential predictors of the IOP variations, in the second session measurements of the above parameters were taken before and after 90 min of AG. A mixed-factorial analysis of variance evaluated differences. Linear regression was conducted to potentially predict the IOP variation with the exercise. After the scheduled exercise, highly significant (p < 0.001, effect size: 0.73) reductions in IOP, but no significant changes in CCT (p = 0.229), were observed. IOP was significantly modified in males, older than 25 years, and subjects with baseline IOP > 14 mmHg (p ≤ 0.001, effect sizes: 0.57–1.02). In contrast, the IOP of females, younger participants, and subjects with baseline IOP ≤ 14 mmHg was not significantly modified (p = 0.114). With the regression analyses, we concluded that both sex and baseline IOP levels were significant predictors of the IOP fluctuation with AG. These findings could be of interest for gymnasts, coaches, ophthalmologists, and/or optometrists in the prevention and control of risk factors associated with glaucoma.

Vildagliptin plasticized hydrogel film in the control of ocular inflammation after topical application: study of hydration and erosion behaviour

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Souvik Nandi ◽  
Abinash Ojha ◽  
Ashirbad Nanda ◽  
Rudra Narayan Sahoo ◽  
Rakesh Swain ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Rabbit Model ◽  
Ocular Inflammation ◽  
Polyethylene Glycol 400 ◽  
Dipeptidyl Peptidase 4 ◽  
Hydrogel Film ◽  
Hydrogel Matrix ◽  
Anti Inflammatory ◽  
Film Formulation

Abstract Vildagliptin (VID) is a dipeptidyl peptidase-4 (DPP-4) inhibitor used in controlling blood glucose level in type 2 diabetes. Vildagliptin improves beta cells function and is also suggested to effectively control the inflammation. The possible ocular anti-inflammatory property of vildagliptin has been explored using topically applied plasticized ocular film formulation. Film formulation was prepared by solvent cast and evaporation method using triethanolamine (TEA), dimethyl sulphoxide (DMSO), and polyethylene glycol 400 (PEG 400) as the plasticizer in HPMC hydrogel matrix base. Anti-inflammatory study was carried out in the carrageenan induced ocular rabbit model. Analytical methods confirmed that the drug was present almost in completely amorphized form in the film formulation. Level of hydration, swelling and erosion rate of the film played the controlling factor in the process of drug release, ocular residence and permeation. Maximum swelling rate of 363 h−1 has been shown by VHT compared to other formulation of VHD and VHP (174 and 242 h−1 respectively). Film containing DMSO exhibited highest in vitro release as well as ex vivo ocular permeation. Film formulation has shown a fast recovery of ocular inflammation in contrast to the untreated eye after inducing inflammation. Plasticized vildagliptin hydrogel film formulation could be utilized in the management and control of ocular inflammation particularly with diabetic retinopathy after proper clinical studies in higher animal and human individuals.

Measurement and Control of Intraocular Pressure in Corneal Disease

1970 ◽  
Vol 10 (2) ◽  
pp. 387-401
Author(s):  
HERBERT E. KAUFMAN ◽  
CAROLE E. WEST ◽  
THOMAS O. WOOD ◽  
CHIEL A. WIND
Keyword(s):  
Intraocular Pressure ◽  
Corneal Disease ◽  
And Control ◽  
Measurement And Control

Effect of topical 0.5% tetracaine hydrochloride on intraocular pressure in ophthalmologically normal cats

2021 ◽  
pp. 1098612X2110059
Author(s):  
Houman Faghihi ◽  
Seyed Mehdi Rajaei ◽  
Hesam Ostadhasan ◽  
Hannah Emami Alagha
Keyword(s):  
Intraocular Pressure ◽  
Artificial Tears ◽  
Control Groups ◽  
Time Points ◽  
Rebound Tonometer ◽  
Significant Difference ◽  
Baseline Values ◽  
The Mean ◽  
And Control

Objectives The aim of this study was to assess the effect of topical tetracaine hydrochloride 0.5% on intraocular pressure (IOP) in ophthalmologically normal cats. Methods Twenty domestic shorthair cats (40 eyes) were used in this study. Each cat was randomly allocated to one of two groups (treatment or control). Baseline IOP (T0) was measured in each cat, and then one drop of tetracaine hydrochloride 0.5% or artificial tears was administered into a randomly chosen eye of each cat in the treatment and control groups, respectively. Repeat IOP measurements were performed at 2 mins (T2), 5 mins (T5), 15 mins (T15) and 30 mins (T30) with a rebound tonometer. Results Mean baseline IOP in all eyes was 20.6 ± 2.5 mmHg. After the unilateral administration of tetracaine, mean IOP decreased significantly in the treated eye at T2 ( P = 0.01). Mean IOP returned to baseline values at T15. The mean IOPs in the treated eyes at T0, T2, T5, T15 and T30 were 20.6 ± 3.3 mmHg, 18.2 ± 2.5 mmHg, 18.2 ± 3.4 mmHg, 20.2 ± 3.2 mmHg and 19.8 ± 2.7 mmHg, respectively. A significant difference in IOP was found at all time points between the tetracaine and control groups (P <0.03). Conclusions and relevance The results of the present study showed a statistically significant reduction in mean IOP 2 mins after the administration of tetracaine hydrochloride 0.5% in the treated eyes of the cats.

scholarly journals Changes in preoperative corneal measurements following same-day intraocular pressure testing with rebound tonometry

2020 ◽  
Vol 12 ◽  
pp. 251584141989207
Author(s):  
Kenneth A. Beckman ◽  
Jodi I. Luchs ◽  
Mark S. Milner ◽  
Richard W. Yee
Keyword(s):  
Intraocular Pressure ◽  
Patient Flow ◽  
Case Series ◽  
Corneal Topography ◽  
Rebound Tonometry ◽  
Pressure Testing ◽  
Significant Difference ◽  
Prospective Case Series ◽  
And Control ◽  
Corneal Staining

Purpose: To evaluate the extent to which rebound tonometry affects corneal surface properties and preoperative corneal measurements. Setting: Four cornea specialty private practices. Design: Prospective case series. Methods: Visual acuity testing, corneal topography, keratometry, and grading of corneal staining were performed on both eyes of 60 randomly selected, previously scheduled patients. Technicians then performed rebound tonometry on one randomly selected eye only. Immediately following, intraocular pressure measurement, corneal topography, keratometry, and corneal staining were repeated on both eyes. Results: None of the 60 study eyes developed increased staining scores following intraocular pressure testing with the Icare ic100. For corneal staining, mean keratometry, and total corneal cylinder, no statistically significant difference was found from the first measurement to the second measurement between the study eyes and control eyes. Conclusion: Rebound tonometry with the Icare ic100 may be used on any patient at any time during the exam without affecting the results of other tests, allowing clinicians to test intraocular pressure prior to preoperative cataract or refractive surgery measurements on the same day. This may allow for significant improvement in patient flow in the office and save patients from the cost and time of extra visits.

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