Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations

2013 ◽  
Vol 52 (5) ◽  
pp. 333-345 ◽  
Author(s):  
Ibrahim Ince ◽  
Catherijne A. J. Knibbe ◽  
Meindert Danhof ◽  
Saskia N. de Wildt
Keyword(s):  
Cytochrome P450 ◽  
Developmental Changes ◽  
Cytochrome P450 3A ◽  
And Function

Does Crizotinib Auto-Inhibit CYP3A in vivo?

Pharmacology ◽  
2020 ◽  
Vol 105 (11-12) ◽  
pp. 715-718
Author(s):  
Abigail R. Bland ◽  
Nensi Shrestha ◽  
Rhonda J. Rosengren ◽  
John C. Ashton
Keyword(s):  
Lung Cancer ◽  
Cytochrome P450 ◽  
Western Blot ◽  
Anaplastic Lymphoma Kinase ◽  
Kinase Inhibitor ◽  
Cyp3a Activity ◽  
Cytochrome P450 3A ◽  
Anaplastic Lymphoma

Crizotinib is a tyrosine kinase inhibitor used to treat anaplastic lymphoma kinase-positive lung cancer. There is in vitro evidence that crizotinib may auto-inhibit cytochrome P450 3A (CYP3A) activity, with important implications for crizotinib pharmacokinetics. In order to test whether crizotinib treatment alters CYP3A activity in vivo, mice were treated with 5 and 25 mg/kg crizotinib (p.o.) daily for 14 days. Results showed that crizotinib treatment did not alter CYP3A activity as determined by erythromycin <i>N</i>-demethylation. In addition, CYP3A polypeptide expression as measured by Western blot was unchanged. Therefore, our results do not support CYP3A inhibition by crizotinib in vivo.

scholarly journals Inhibitory Effect of Lygodium Root on the Cytochrome P450 3A Enzyme in vitro and in vivo

2020 ◽  
Vol Volume 14 ◽  
pp. 1909-1919
Author(s):  
Yunfang Zhou ◽  
Ailian Hua ◽  
Quan Zhou ◽  
Peiwu Geng ◽  
Feifei Chen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effect ◽  
Cytochrome P450 3A

scholarly journals Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hyun-Jong Cho ◽  
In-Soo Yoon
Keyword(s):  
Cytochrome P450 ◽  
Glycoprotein P ◽  
Metabolizing Enzymes ◽  
Herbal Products ◽  
P Glycoprotein ◽  
Concurrent Use ◽  
Substrate Drug ◽  
And Function

The concurrent use of drugs and herbal products is becoming increasingly prevalent over the last decade. Several herbal products have been known to modulate cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) which are recognized as representative drug metabolizing enzymes and drug transporter, respectively. Thus, a summary of knowledge on the modulation of CYP and P-gp by commonly used herbs can provide robust fundamentals for optimizing CYP and/or P-gp substrate drug-based therapy. Herein, we review ten popular medicinal and/or dietary herbs as perpetrators of CYP- and P-gp-mediated pharmacokinetic herb-drug interactions. The main focus is placed on previous works on the ability of herbal extracts and their phytochemicals to modulate the expression and function of CYP and P-gp in severalin vitroandin vivoanimal and human systems.

scholarly journals In vitro and in vivo cytochrome P450 3A enzyme inhibition by Aframomum melegueta and Denniettia tripetala extracts

2017 ◽  
Vol 10 (6) ◽  
pp. 576-581 ◽  
Author(s):  
Sunday O. Nduka ◽  
Mathew J. Okonta ◽  
Daniel L. Ajaghaku ◽  
Chinwe V. Ukwe
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Inhibition ◽  
Cytochrome P450 3A

In vitro and in vivo Inhibitory Effects of Glycyrrhetinic Acid on Cytochrome P450 3A Activity

Pharmacology ◽  
2010 ◽  
Vol 86 (5-6) ◽  
pp. 287-292 ◽  
Author(s):  
Hai Yun Li ◽  
Wen Xu ◽  
Juan Su ◽  
Xi Zhang ◽  
Li Wei Hu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Glycyrrhetinic Acid ◽  
Cytochrome P450 3A ◽  
Inhibitory Effects

Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo

2009 ◽  
Vol 36 (4-5) ◽  
pp. 401-411 ◽  
Author(s):  
Xiuhua Ren ◽  
Xinliang Mao ◽  
Lei Cao ◽  
Kewen Xue ◽  
Luqin Si ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Nonionic Surfactants ◽  
Cytochrome P450 3A

In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants

2018 ◽  
Vol 152 ◽  
pp. 272-278 ◽  
Author(s):  
Kazuyuki Nakanishi ◽  
Shotaro Uehara ◽  
Takashi Kusama ◽  
Takashi Inoue ◽  
Kanami Shimura ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Common Marmoset ◽  
Cytochrome P450 3A
Sign in / Sign up

Export Citation Format

Share Document