Biosimilar Monoclonal Antibodies for Inflammatory Bowel Disease: Current Comfort and Future Prospects

Drugs ◽  
2016 ◽  
Vol 76 (15) ◽  
pp. 1413-1420 ◽  
Author(s):  
Krisztina B. Gecse ◽  
Péter L. Lakatos
Keyword(s):  
Inflammatory Bowel Disease ◽  
Monoclonal Antibodies ◽  
Bowel Disease ◽  
Future Prospects ◽  
Inflammatory Bowel

Advances in the Development of Janus Kinase Inhibitors in Inflammatory Bowel Disease: Future Prospects

Drugs ◽  
2017 ◽  
Vol 77 (10) ◽  
pp. 1057-1068 ◽  
Author(s):  
Mathurin Flamant ◽  
Josselin Rigaill ◽  
Stephane Paul ◽  
Xavier Roblin
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Kinase Inhibitors ◽  
Janus Kinase ◽  
Future Prospects ◽  
Janus Kinase Inhibitors ◽  
Inflammatory Bowel

scholarly journals Exosomes in Intestinal Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Kanchana K. Ayyar ◽  
Alan C. Moss
Keyword(s):  
Inflammatory Bowel Disease ◽  
Monoclonal Antibodies ◽  
Breast Milk ◽  
Nucleic Acids ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Fecal Samples ◽  
Inflammatory Bowel

Exosomes are 30–150 nm sized vesicles released by a variety of cells, and are found in most physiological compartments (feces, blood, urine, saliva, breast milk). They can contain different cargo, including nucleic acids, proteins and lipids. In Inflammatory Bowel Disease (IBD), a distinct exosome profile can be detected in blood and fecal samples. In addition, circulating exosomes can carry targets on their surface for monoclonal antibodies used as IBD therapy. This review aims to understand the exosome profile in humans and other mammals, the cargo contained in them, the effect of exosomes on the gut, and the application of exosomes in IBD therapy.

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