scholarly journals Clinical Pharmacokinetics of Oral Sodium Selenite and Dosing Implications in the Treatment of Patients with Metastatic Cancer

Drugs in R&D ◽  
2021 ◽  
Author(s):  
Priya Jayachandran ◽  
Susan J. Knox ◽  
Maria Garcia-Cremades ◽  
Radojka M. Savić
1998 ◽  
Vol 08 (02n03) ◽  
pp. 89-97 ◽  
Author(s):  
MASAHIRO NATSUHORI ◽  
TAMAE NAGAOKA ◽  
NOBUHIKO ITO ◽  
KOICHIRO SERA ◽  
SHOJI FUTATSUGAWA

Selenium ( Se ) concentrations in plasma, urine, and feces were determined by PIXE analysis before and after intravenous (iv) / oral (po) administration of sodium selenite (a dose equivalent to 2 mg/kg of selenium) to rats. The concentration-time profiles of Se were analyzed by a pharmacokinetic approach. The plasma Se profile after iv injection was biphasic and well-fit to a 2-compartment open model, showing two half lives (t1/2). The first t1/2 was about 0.3 hr and the second t1/2 was 6.9 hrs. The plasma concentration reached almost basal level after about 80 hrs of injection. On the other hand, plasma profiles after po administration showed absorption rate-limiting elimination. The bioavailability of oral sodium selenite (about 49%) and significantly higher amount of fecal Se excretion indicated relatively poor intestinal absorption of sodium selenite, compared to the previously published data. Urinary Se excretion was almost comparable between iv and po groups. The total recovery of the dose excreted in urine and feces was 30 ± 10 % in iv and 56 ± 15 % in po group. The renal excretion was considered to be a major route of Se excretion after absorption. Significant amount of Se that was not fully excreted was noted, suggesting Se distribution or accumulation in organs, together with volatile excretion.


2019 ◽  
Vol 12 (11) ◽  
pp. 1525-1531
Author(s):  
Susan J. Knox ◽  
Priya Jayachandran ◽  
Christine A. Keeling ◽  
Kathryn J. Stevens ◽  
Navjot Sandhu ◽  
...  

2007 ◽  
Vol 20 (2) ◽  
pp. 213 ◽  
Author(s):  
Ji Yon Jo ◽  
Jeong Hoon Suh ◽  
Hwa Yong Shin ◽  
Yong Min Choi ◽  
Moon Sun Bang ◽  
...  

2012 ◽  
Vol 3 (1) ◽  
pp. 489-490
Author(s):  
M. SIVA SANKAR M. SIVA SANKAR ◽  
◽  
K. SUJATHA K. SUJATHA ◽  
P. NEERAJA P. NEERAJA

2020 ◽  
Vol 10 (2) ◽  
pp. 48-52
Author(s):  
Jeevitha M ◽  
Kalaichandar M ◽  
Kirubakaran K ◽  
Baskaran V ◽  
Kokila K ◽  
...  

Low blood pressure truly includes a worse prognosis than the excessive blood strain. This mechanism,bills for the "reverse causation "seen within the haemodialysis’ patients, the company of conventional risk elements, such as high blood pressure, hyperlipidemia, and obesity, appear to be a worst diagnosis.Exogenous erythropoietic products can growth blood strain and requirement of antihypertensive tablets.30 Chronic ECFV overload secondary to activation of renin-angiotensin-aldosterone axisand disturbances inside the stability of vasoconstrictors and the vasodilators make a contribution to high blood pressure. Improvement in blood pressure can be introduced out with oral sodium restriction, diuretics, and fluid elimination with dialysis. Some patients will continue to be hypertensive notwithstanding of the careful attention to ECFV reputation. LVH is related with reduced endurance of sufferers on hemo/peritoneal dialysis .Lower five year survival charge in ESRD patients with LVH have a 30% than people missing LVH. This have a look at produces the mean carotid artery intima-medial thickness turned into higher in sufferers with superior CKD although it did now not attain statistical significance, probable due to smaller sample size.It was also observed that carotid intima medial thickness had no correlation with dyslipidemia. Even though the patients had maintained significantly normal cholesterol and high HDL levels, there was an increase in CIMT. Therefore, CKD patients, CIMT cannot be predicted based on the traditional atherosclerotic risk factors like serum cholesterol and HDL.


Author(s):  
I.I. Seregina ◽  
◽  
I.G. Makarskaya

Abstract:In model experiments in soil culture, the effect of different methods of treatment with sodium selenite on the photosynthetic activity of spring wheat variety Zlata was studied under extreme growing conditions. Under drought conditions, the inhibition of the growth of the photosynthetic surface of spring wheat plants was revealed. Under conditions of excessive water supply, a sharp decrease in the area of the assimilating surface of wheat plants was observed. The positive effect of sodium selenite solution on the photosynthetic activity of spring wheat plants was established with insufficient and excessive water supply to wheat plants.


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