“Not This One”: Experimental Use of the Approval and Disapproval Ballot

2021 ◽  
Author(s):  
Annick Laruelle
Keyword(s):  
Experimental Use

A PROVERBS TEST FOR CLINICAL AND EXPERIMENTAL USE

1956 ◽  
Vol 2 (g) ◽  
pp. 1-12 ◽  
Author(s):  
DONALD R. GORHAM
Keyword(s):  
Experimental Use

Is Pre-College Interpersonal Trauma Associated with Cannabis Use?

2020 ◽  
Author(s):  
Terrell A Hicks ◽  
Daniel Bustamante ◽  
Kaitlin E Bountress ◽  
Amy Adkins ◽  
Dace S Svikis ◽  
...  
Keyword(s):  
College Students ◽  
Interpersonal Trauma ◽  
Demographic Variables ◽  
Cannabis Use ◽  
First Year ◽  
Southeastern Part ◽  
First Year College ◽  
Large N ◽  
First Year College Students ◽  
Experimental Use

Objective: To examine the prevalence and correlates of lifetime cannabis use (i.e., experimental [use 1-5 times] and non-experimental [use ≥ 6 times]) in relation to demographics, interpersonal trauma (IPT), and alcohol and nicotine use.Participants: A large (n = 9,889) representative sample of college students at an urban college campus in the southeastern part of the United States.Methods: Participants were 4 cohorts of first-year college students who completed measures of demographic variables, cannabis, alcohol, nicotine, and IPT. Associations were estimated using multinomial logistic regressions.Results: The prevalence of lifetime cannabis use was 45.5%. Specifically, 28.1% reported non-experimental cannabis use and 17.4% reported experimental cannabis use. Race, cohort, nicotine, and IPT were associated with experimental and non-experimental cannabis use. Additionally, alcohol and sex were associated with non-experimental cannabis use.Conclusions: Results show that cannabis use is prevalent among college students and is associated with race, IPT, and other substance use.

ON THE PREPARATION OF HUMAN INSULIN FOR EXPERIMENTAL USE*

1949 ◽  
Vol 9 (6) ◽  
pp. 481-485 ◽  
Author(s):  
WILLIAM FRANKLIN ◽  
FRANCIS C. LOWELL
Keyword(s):  
Human Insulin ◽  
Experimental Use

scholarly journals A candidate gene identified in converting platycoside E to platycodin D from Platycodon grandiflorus by transcriptome and main metabolites analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xinglong Su ◽  
Yingying Liu ◽  
Lu Han ◽  
Zhaojian Wang ◽  
Mengyang Cao ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Orthogonal Experiment ◽  
Triterpenoid Saponin ◽  
Gene Encoding ◽  
Triterpenoid Saponins ◽  
Platycodin D ◽  
Polysaccharide Content ◽  
Saponin Biosynthesis ◽  
Polysaccharide Synthesis ◽  
Experimental Use

AbstractPlatycodin D and platycoside E are two triterpenoid saponins in Platycodon grandiflorus, differing only by two glycosyl groups structurally. Studies have shown β-Glucosidase from bacteria can convert platycoside E to platycodin D, indicating the potential existence of similar enzymes in P. grandiflorus. An L9(34) orthogonal experiment was performed to establish a protocol for calli induction as follows: the optimal explant is stems with nodes and the optimum medium formula is MS + NAA 1.0 mg/L + 6-BA 0.5 mg/L to obtain callus for experimental use. The platycodin D, platycoside E and total polysaccharides content between callus and plant organs varied wildly. Platycodin D and total polysaccharide content of calli was found higher than that of leaves. While, platycoside E and total polysaccharide content of calli was found lower than that of leaves. Associating platycodin D and platycoside E content with the expression level of genes involved in triterpenoid saponin biosynthesis between calli and leaves, three contigs were screened as putative sequences of β-Glucosidase gene converting platycoside E to platycodin D. Besides, we inferred that some transcription factors can regulate the expression of key enzymes involved in triterpernoid saponins and polysaccharides biosynthesis pathway of P. grandiflorus. Totally, a candidate gene encoding enzyme involved in converting platycoside E to platycodin D, and putative genes involved in polysaccharide synthesis in P. grandiflorus had been identified. This study will help uncover the molecular mechanism of triterpenoid saponins biosynthesis in P. grandiflorus.

scholarly journals The path toward ectogenesis: looking beyond the technical challenges

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Seppe Segers
Keyword(s):  
Neonatal Intensive Care ◽  
Animal Studies ◽  
Current Data ◽  
Safety Testing ◽  
Future Challenges ◽  
Critical Issues ◽  
Expected Benefits ◽  
Physical Impact ◽  
Biological Parenthood ◽  
Experimental Use

Abstract Background Breakthroughs in animal studies make the topic of human application of ectogenesis for medical and non-medical purposes more relevant than ever before. While current data do not yet demonstrate a reasonable expectation of clinical benefit soon, several groups are investigating the feasibility of artificial uteri for extracorporeal human gestation. Main text This paper offers the first comprehensive and up to date discussion of the most important pros and cons of human ectogenesis in light of clinical application, along with an examination of crucial ethical (and legal) issues that continued research into, and the clinical translation of, ectogenesis gives rise to. The expected benefits include advancing prenatal medicine, improving neonatal intensive care, and providing a novel pathway towards biological parenthood. This comes with important future challenges. Prior to human application, important questions have to be considered concerning translational research, experimental use of human fetuses and appropriate safety testing. Key questions are identified regarding risks to ectogenesis’ subjects, and the physical impact on the pregnant person when transfer from the uterus to the artificial womb is required. Critical issues concerning proportionality have to be considered, also in terms of equity of access, relative to the envisaged application of ectogenesis. The advent of ectogenesis also comes with crucial issues surrounding abortion, extended fetal viability and moral status of the fetus. Conclusions The development of human ectogenesis will have numerous implications for clinical practice. Prior to human testing, close consideration should be given to whether (and how) ectogenesis can be introduced as a continuation of existing neonatal care, with due attention to both safety risks to the fetus and pressures on pregnant persons to undergo experimental and/or invasive procedures. Equally important is the societal debate about the acceptable applications of ectogenesis and how access to these usages should be prioritized. It should be anticipated that clinical availability of ectogenesis, possibly first as a way to save extremely premature fetuses, may spark demand for non-medical purposes, like avoiding physical and social burdens of pregnancy.

The Experimental-Use Defence to Patent Infringement: A Comparative Assessment

2006 ◽  
Vol 56 (4) ◽  
pp. 333-369
Author(s):  
Norman Siebrasse ◽  
Keith Charles Culver
Keyword(s):  
Comparative Assessment ◽  
Patent Infringement ◽  
Experimental Use

Observations on the use of Trichostrongylus colubriformis (Nematoda) infections of guinea-pigs for laboratory experiments

Parasitology ◽  
1963 ◽  
Vol 53 (1-2) ◽  
pp. 189-199 ◽  
Author(s):  
R. F. Sturrock
Keyword(s):  
Multivariate Analysis ◽  
Guinea Pigs ◽  
Worm Burden ◽  
Laboratory Experiments ◽  
Statistical Treatment ◽  
Post Mortem ◽  
Infective Larvae ◽  
Final Weight ◽  
Cure Mechanism ◽  
Experimental Use

Four groups of guinea-pigs were infected with a range of doses of T. colubriformis. The infections were followed by egg counts and weight measurements, and the adult worms were recovered from the animals post mortem. A multivariate analysis, details of which are given in an appendix, showed that the sensitivity of the measures used was, in descending order, final weight, total egg count and worm burden. The course of the infection is discussed in view of the apparent self-cure mechanism. Precautions are outlined for the experimental use of this hostparasite relationship.The author is grateful to Professor B. G. Peters for his advice on this work, to Dr P. Silverman of Allen and Hanburys Limited for a supply of T. colubriformis infective larvae and to Dr R. E. Blackith for his advice on the statistical treatment of the data.

Experimental Use of Gas Condensate for the Prevention of Fly Breeding

1945 ◽  
Vol 38 (1) ◽  
pp. 23-25
Author(s):  
S. W. Simmons ◽  
W. E. Dove
Keyword(s):  
Gas Condensate ◽  
Experimental Use
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