Unsymmetric primal-dual problem

Keyword(s):  
2019 ◽  
Vol 16 (07) ◽  
pp. 1850110 ◽  
Author(s):  
Abdellatif Ellabib ◽  
Youssef Ouakrim

The identification of multivalued parameters is formulated as a constraint minimization problem called primal problem. We embed it in a family of perturbed problems and we associate a dual problem with it using the conjugate functions. Basing on the primal-dual relationship, under some qualification conditions on the parameters to be identified we elaborate the well posedeness, convergence and stability of the solution assuming. Numerical simulations are described in the end for the identification of discontinuous dispersion tensor in transport equations.


Author(s):  
Jaya Pratha Sebastiyar ◽  
Martin Sahayaraj Joseph

Distributed joint congestion control and routing optimization has received a significant amount of attention recently. To date, however, most of the existing schemes follow a key idea called the back-pressure algorithm. Despite having many salient features, the first-order sub gradient nature of the back-pressure based schemes results in slow convergence and poor delay performance. To overcome these limitations, the present study was made as first attempt at developing a second-order joint congestion control and routing optimization framework that offers utility-optimality, queue-stability, fast convergence, and low delay.  Contributions in this project are three-fold. The present study propose a new second-order joint congestion control and routing framework based on a primal-dual interior-point approach and established utility-optimality and queue-stability of the proposed second-order method. The results of present study showed that how to implement the proposed second-order method in a distributed fashion.


2021 ◽  
Vol 174 (1) ◽  
Author(s):  
Amirlan Seksenbayev

AbstractWe study two closely related problems in the online selection of increasing subsequence. In the first problem, introduced by Samuels and Steele (Ann. Probab. 9(6):937–947, 1981), the objective is to maximise the length of a subsequence selected by a nonanticipating strategy from a random sample of given size $n$ n . In the dual problem, recently studied by Arlotto et al. (Random Struct. Algorithms 49:235–252, 2016), the objective is to minimise the expected time needed to choose an increasing subsequence of given length $k$ k from a sequence of infinite length. Developing a method based on the monotonicity of the dynamic programming equation, we derive the two-term asymptotic expansions for the optimal values, with $O(1)$ O ( 1 ) remainder in the first problem and $O(k)$ O ( k ) in the second. Settling a conjecture in Arlotto et al. (Random Struct. Algorithms 52:41–53, 2018), we also design selection strategies to achieve optimality within these bounds, that are, in a sense, best possible.


Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 42
Author(s):  
Walter M. Yamada ◽  
Michael N. Neely ◽  
Jay Bartroff ◽  
David S. Bayard ◽  
James V. Burke ◽  
...  

Population pharmacokinetic (PK) modeling has become a cornerstone of drug development and optimal patient dosing. This approach offers great benefits for datasets with sparse sampling, such as in pediatric patients, and can describe between-patient variability. While most current algorithms assume normal or log-normal distributions for PK parameters, we present a mathematically consistent nonparametric maximum likelihood (NPML) method for estimating multivariate mixing distributions without any assumption about the shape of the distribution. This approach can handle distributions with any shape for all PK parameters. It is shown in convexity theory that the NPML estimator is discrete, meaning that it has finite number of points with nonzero probability. In fact, there are at most N points where N is the number of observed subjects. The original infinite NPML problem then becomes the finite dimensional problem of finding the location and probability of the support points. In the simplest case, each point essentially represents the set of PK parameters for one patient. The probability of the points is found by a primal-dual interior-point method; the location of the support points is found by an adaptive grid method. Our method is able to handle high-dimensional and complex multivariate mixture models. An important application is discussed for the problem of population pharmacokinetics and a nontrivial example is treated. Our algorithm has been successfully applied in hundreds of published pharmacometric studies. In addition to population pharmacokinetics, this research also applies to empirical Bayes estimation and many other areas of applied mathematics. Thereby, this approach presents an important addition to the pharmacometric toolbox for drug development and optimal patient dosing.


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