A follow-up study on short-term treatment of agoraphobia

1992 ◽  
Vol 30 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Hanneke Rijken ◽  
Floor Kraaimaat ◽  
Corine de Ruiter ◽  
Bert Garssen
Keyword(s):  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Follow Up Study

Short-Term Therapy for Somatization Disorder: A Cognitive Behavioral Approach

2000 ◽  
Vol 14 (4) ◽  
pp. 373-380 ◽  
Author(s):  
Lesley A. Allen
Keyword(s):  
Term Treatment ◽  
Behavioral Approach ◽  
Cognitive Behavioral ◽  
Treatment Manual ◽  
Somatization Disorder ◽  
Term Therapy ◽  
Short Term ◽  
Short Term Treatment ◽  
Present Case Report

Somatization disorder is a distressing, disabling, and costly disorder. A short-term treatment manual, applying cognitive behavioral techniques to the maladaptive behaviors and thoughts associated with somatization disorder, was developed. The present case report examines the effectiveness of this 10-session treatment with a 38-year-old woman diagnosed with somatization disorder. The results show an improvement in the patient’s physical and emotional distress at termination, 6-month follow-up, and 12-month follow-up assessments.

The Role of Contrast-Enhanced Ultrasound in Guiding Radiofrequency Ablation of Hepatocellular Carcinoma

2015 ◽  
Vol 66 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Andy K.W. Chan ◽  
Chris Hegarty ◽  
Darren Klass ◽  
Eric Yoshida ◽  
Stephen Chung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Complete Response ◽  
Term Treatment ◽  
Contrast Enhanced Ultrasound ◽  
Short Term ◽  
Short Term Treatment ◽  
Contrast Enhanced ◽  
Enhanced Computed Tomography

Purpose The objective of the study was to determine the efficacy of contrast-enhanced ultrasound (CEUS) using ultrasound (US)-specific microbubbles in guiding radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Methods A retrospective analysis of 50 patients with HCC treated with CEUS guided RFA using perflutren at our institution was performed. CEUS images were first compared to B-mode US images performed at the same RFA session to determine the ability of CEUS to increase the conspicuity of lesions. A qualitative score (1 = poor, 2 = fair, 3 = excellent) was used to grade the ability to visualize the lesions. The preprocedure CEUS images were then evaluated using the most recent prior contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI). The efficacy of the treatment was evaluated with short-term follow-up imaging (median 1 month) for presence of residual or recurrent disease. Results CEUS allows at least fair visualization (score ≥2) in 78% (reader 1) and 80% (reader 2) of the lesions not visualized by B-mode US, and 50% (reader 1) and 42% (reader 2) of the lesions poorly visualized by B-mode US. Lesion appearances on CEUS are largely concordant with those on CT or MRI: 88% for reader 1, 96% for reader 2. With CEUS-guided RFA, complete response was achieved in the vast majority of the lesions at short-term follow-up: 82% for reader 1, 94% for reader 2. Conclusions CEUS increases the conspicuity and provides better characterization of hypervascular HCC that are either not seen or poorly seen on B-mode US, and CEUS provides real-time guidance of RFA with good short-term treatment responses.

Changes in Bone Metabolism Induced by Short-Term Treatment with G-CSF for the Mobilization of Allogeneic Hematopoietic Progenitor Cells.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 1772-1772
Author(s):  
Frank P. Kroschinsky ◽  
Sybille Bergmann ◽  
Kirsten Poppe-Thiede ◽  
Gabriele Siegert ◽  
Claudia Rutt ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Stem Cell ◽  
Bone Resorption ◽  
Bone Formation ◽  
Bone Metabolism ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Normal Ranges

Abstract Short-term treatment with granulocyte colony-stimulating factor (G-CSF) has become a standard procedure for the mobilization of allogeneic peripheral blood progenitor cells (PBPC) in healthy donors. While osteopenia was observed after G-CSF long-term treatment in patients with chronic neutropenia and in G-CSF overexpressing animal models, the information about the effects of G-SCF priming in PBPC donors is limited. Bone pain as the most frequent acute toxicity and the transient increase of serum alkaline phosphatase suggest an effect on bone metabolism also during G-CSF treatment for mobilization. A total of 93 unrelated stem cell donors (21 female, 72 male; median age 35 years) were included in a prospective study to investigate the changes in bone metabolism induced by short-term treatment with G-CSF. Mobilization treatment consisted of 7.5 μg/kg body weight lenograstim (Granocyte™, Chugai Pharma Inc., Tokyo, Japan) for five days. Leukaphereses were performed on day 5 and 6. Samples of blood and urine were taken at pre-donation health-check (before rhG-CSF stimulation, baseline), at the first day of apheresis (leukapheresis) and four weeks after donation (follow-up) and tested for a panel of biochemical markers for bone formation and bone resorption. Stem cell collections were not performed in all donors who were included at baseline, therefore data from leukapheresis are available from 73 donors, and 63 donors were examined at follow-up. Serum bone alkaline phosphatase (BAP) and serum ostase which are both markers for bone formation significantly increased from baseline to leukapheresis (p<0.0001). Both returned to baseline values within 4 weeks after donation. In contrast tartrat-resistent alkaline phosphatase (TRAP) 5b, which is produced by osteoclasts, was found to be decreased at leukapheresis (p=0.001) and at follow-up (p=0.005). The collagen type I crosslinks in urine increased significantly from baseline to follow-up (telopeptides p=0.022; deoxypyridinoline p=0,012). The ligand of receptor activator of NF-kB (RANKL) and osteoprotergerin (OPG), which are members of the TNF receptor family and play a role in the regulation of osteoclast recruitment were also affected by G-CSF treatment, which was reflected by a significant increase of OPG/RANKL-ratio (p=0.01). Serum parathormon (PTH) showed a highly significant increase from baseline to leukapheresis (p<0.0001), but was found at normal ranges in all donors at follow-up. Pearson’s correlation of bone markers with circulating CD34+ hematopoietic progenitors before first leukapheresis did not reveal an impact of these parameters on mobilization efficacy. In conclusion the results confirm the influence of G-CSF short-term treatment on bone metabolism in allogeneic stem cell donors. An initial osteoblastic stimulation is followed by a period of increased bone resorption which seems to be not finished 4 weeks after G-CSF treatment. However, the changes in urine crosslink concentrations occurred within the normal ranges of the used assays in the vast majority of donors and therefore we do not assume an impact on the safety of the mobilization procedure. The complex regulation of bone metabolism by humoral and cellular effectors and the cause of transient hyperparathyroidism need further investigations.

scholarly journals Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Nika Aleksandra Kravos ◽  
Andrej Janež ◽  
Katja Goričar ◽  
Vita Dolžan ◽  
Mojca Jensterle
Keyword(s):  
Longitudinal Study ◽  
Eating Behavior ◽  
Polycystic Ovary ◽  
Term Treatment ◽  
Endocrine Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Beneficial Impact

Abstract Background Metformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we stop treatment. We compared the effects of metformin withdrawal after long-term (LT) and short term (ST) treatment in PCOS women that had previously well responded to metformin. Methods We conducted observational longitudinal study including 44 PCOS women (31 (28–36) years and BMI 32.5 (27.7–34.9) kg/m2) that were followed for 6 months after metformin withdrawal. Prior inclusion, ST group had been treated with metformin on average for 1.03 ± 0.13 year, LT group for 5.07 ± 2.52 years. We followed anthropometric, metabolic, reproductive parameters and eating behavior as assessed by TFEQ-R18. Results After metformin withdrawal, ST group gained significant amount of weight (from 92 (75.5–107.3) kg to 96 (76–116) kg; p = 0.019). Weight tended to increase also in LT users (from 87 (75–103) to 87 (73–105) kg; p = 0.058). More women in LT group maintained stable weight (27% in LT group vs 15% in ST group). Eating behavior deteriorated in both groups. Withdrawal of metformin resulted in a decrease of menstrual frequency (6 (6–6) to 6 (4–6) menstrual bleeds per 6 months; p = 0.027) and in borderline increase of androstenedione (6.4 (4.6–7.6) to 7.8 (4.8–9.6) nmol/L; p = 0.053) in LT group. Waist circumference, HOMA and glucose homeostasis remained stable in both groups. There were no differences between groups at 6-month follow up. Conclusion Collectively, present study implies some metabolic and endocrine treatment legacy in both groups as well as some group-specific deteriorations in clinical parameters 6 months after metformin withdrawal. Trial registration: The study is registered at Clinical Trials with reference No. NCT04566718

scholarly journals MP36: Short-term side effects associated with opioids for acute pain

CJEM ◽  
2019 ◽  
Vol 21 (S1) ◽  
pp. S55
Author(s):  
R. Daoust ◽  
J. Paquet ◽  
A. Cournoyer ◽  
E. Piette ◽  
J. Morris ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Side Effects ◽  
Acute Pain ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Opioid Prescription ◽  
Pain Condition ◽  
Dose Response Effect

Introduction: Opioid side effects are common when treating chronic pain. However, the rate of opioid side effects for acute pain has rarely been examined, particularly in the post emergency department (ED) setting. The objective of this study was to evaluate the short-term incidence of opioid induced side effects (constipation, nausea/vomiting, dizziness, and drowsiness) in patients discharged from the ED with an opioid prescription. Methods: This was a prospective cohort study of patients aged ≥18 years that visited the ED for an acute pain condition (≤ 2 weeks) and were discharged with an opioid prescription. Patients completed a 14-day diary assessing daily pain medication use and side effects. Results: Mean age of the 386 patients included was 55 ± 16 years; 50% were women. During the 2-week follow-up, 80% of patients consumed at least one dose of opioids. Among the patients who used opioids, 38% (95%CI: 33-48) reported constipation, 27% (95%CI:22-32) nausea/vomiting, 30% (95%CI:25-35) dizziness, 51% (95%CI:45-57) drowsiness, and 77% (95%CI:72-82) reported any side effects. Adjusting for age, sex, and pain condition, patients who used opioids were more likely to report any side effect (OR 7.5, 95%CI:4.3-13.3) and constipation (OR 7.5, 95%CI:3.1-17.9). A significant dose response effect was observed for constipation but not for the other side effects. Nausea/vomiting (OR 2.0, 95%CI:1.1-3.6) and dizziness (OR 1.9, 95%CI:1.1-3.4) were associated with oxycodone compared to morphine. Conclusion: Similar to chronic pain, opioid side effects are highly prevalent during short-term treatment for acute pain. Physicians should be aware and inform patients about those side effects.

scholarly journals Diagnostic value of 3D-FLAIR MRI in children with sudden deafness caused by inner ear hemorrhage

2021 ◽  
Vol 4 (4) ◽  
pp. e000280
Author(s):  
Fu Sheng Gao ◽  
Xuan Jia ◽  
XiaoHui Ma ◽  
Jing Bi ◽  
Qiang Shu
Keyword(s):  
Inner Ear ◽  
Diagnostic Value ◽  
Term Treatment ◽  
Sudden Deafness ◽  
Short Term ◽  
Short Term Treatment ◽  
Flair Sequence ◽  
Mri Sequences ◽  
3D Flair

ObjectiveTo investigate the diagnostic value of three-dimensional fluid-attenuated inversion recovery (3D-FLAIR) MRI in children with sudden deafness caused by inner ear hemorrhage.MethodsThe diagnostic efficacies of three different MRI sequences in the examination of the inner ear for 32 children with sudden deafness were compared. Hearing examination results and 3-month follow-up outcomes were analyzed.ResultsThe age of 32 children with sudden deafness ranged from 5 to 18 years. MRI was performed from 1 to 18 days after onset. Six cases of sudden deafness caused by inner ear hemorrhage were finally diagnosed clinically. For different MRI sequences, the 3D-FLAIR sequence detected five positive cases; the conventional T1-weighted image sequence also detected five positive cases; but the conventional T2-weighted image sequence only detected three positive cases. The sensitivity and specificity of the 3D-FLAIR sequence in the diagnosis of inner ear hemorrhage were 83.3% (5/6) and 96.2% (25/26), respectively, and the area under the curve value of the receiver operating characteristic curve was 0.897. In the hemorrhage group, all six cases had extremely severe sensorineural hearing loss, and the hearing recovery was ineffective after 3 months of follow-up. The degree of hearing impairment, 3-month short-term treatment efficacy, and 3D-FLAIR MRI in the diagnosis of inner ear hemorrhage between hemorrhage group and non-hemorrhage group were statistically significant (p=0.043, p=0.000, p=0.000).Conclusions3D-FLAIR MRI is helpful for the diagnosis of inner ear hemorrhage in children with sudden deafness. Besides, short-term treatment indicates poor effects on children with severe hearing impairment.

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