High frequency of celiac disease in down's syndrome: Screening methods

1995 ◽  
Vol 108 (4) ◽  
pp. A16
2020 ◽  
Vol 36 (S1) ◽  
pp. 30-30
Author(s):  
Changjia Fan ◽  
Wenru Shang ◽  
Jiayan Huang ◽  
Yang Wan

IntroductionBirth defects seriously affect children's survival and quality of life and bring great suffering and financial burden to children and their families. Down's syndrome is one of the most common birth defects. Compared with traditional serological screening methods, non-invasive prenatal testing (NIPT) has higher sensitivity and specificity in the screening of Down's syndrome. In April 2017, the People's Government of Fuyang City, Anhui Province launched a NIPT free screening program. From the perspective of the beneficiary, this research investigated the awareness, willingness to pay and satisfaction of pregnant women in Fuyang City, Anhui Province, to better improve the use of NIPT.MethodsA questionnaire survey was conducted on 1,221 pregnant women who experienced this program in Fuyang City, Anhui Province. Multivariate ordered logistic regression models were established to analyze the factors affecting the satisfaction of NIPT.ResultsA total of 1,217 valid questionnaires were collected. Research indicated 82.5 percent knew about NIPT and 81.9 percent were willing to pay personally when its price was CNY 800 (USD 113.88) per test among pregnant women. The satisfaction of pregnant women with NIPT showed that the waiting time for test results was relatively low (4.5 out of 5 points) compared with other aspects of satisfaction. The higher the education level of the pregnant women, the lower their satisfaction with NIPT.ConclusionsIt is necessary to pay attention to the characteristics of education and to improve the awareness and satisfaction of NIPT among pregnant women. Meanwhile, if it is affordable enough for NIPT services to be provided by the government, this mode should be promoted. In conjunction with the willingness to pay of pregnant women, NIPT payment methods should be developed appropriately.


2013 ◽  
Vol 2 ◽  
pp. 77-85
Author(s):  
Aleksandra Nowak-Oczkowska ◽  
Anna Szaflarska-Popławska ◽  
Anetta Soroczyńska-Wrzyszcz

2021 ◽  
Vol 15 (10) ◽  
pp. 2582-2583
Author(s):  
Sana Pervez ◽  
Syed Sajid Munir ◽  
Maimoona Saeed

Aim: Incidence of celiac disease among children with down’s syndrome Setting: Pediatrics department, Khyber Teaching Hospital, Peshawar Study design: Cross sectional study Study duration: 20/7/2019 to 20/1/2020 Methodology: A total of 241 subjects were selected. Five ml of venous blood was obtained from all patients to detect the Anti-tTG Ab. Among those patients who are positive for the antibody, endoscopy and biopsy specimen from duodenum were sent to hospital laboratory to confirm the presence of villus atrophy. Results: Mean age was 8 ± 4.57. 44% children were male and 56% children were female. More over 4% children had celiac disease and 96% children didn’t have celiac disease. Conclusion: The frequency of celiac disease was 4% among children presenting with Down syndrome. Keywords: Celiac disease, Down’s syndrome.


2008 ◽  
Vol 40 (10) ◽  
pp. A98
Author(s):  
L. Pensabene ◽  
D. Concolino ◽  
S. Sestito ◽  
G. Nigro ◽  
E. Focarelli ◽  
...  

1996 ◽  
Vol 23 (3) ◽  
pp. 303-306 ◽  
Author(s):  
P. Failla ◽  
C. Ruberto ◽  
M. C. Pagano ◽  
M. Lombardo ◽  
G. Bottaro ◽  
...  

2018 ◽  
Vol 9 (1) ◽  
pp. 271-273
Author(s):  
Zannatul Ferdouse ◽  
Kazi Ashraful Islam ◽  
Afsana Anwar Miti ◽  
Sayeda Tabassum Alam ◽  
Shaheen Akhter ◽  
...  

Background : Down’s syndrome (DS) is the most common chromosomal abnormality. Some autoimmune diseases are over represented in children with DS like insulin dependent diabetes mellitus, autoimmune thyroiditis and celiac disease (CD). Classical presentations of CD may be absent in children with Down’s syndrome. Worldwide different tests are available for the diagnosis of CD. Among these, tissue transglutaminase (tTG) is cost effective, sensitive and the only test available in Bangladesh.Objective : To ascertain the frequency of celiac disease and their clinical presentations in children with Down’s syndrome by doing serum tTG (IgA) level.Methods : A cross sectional study was carried out in the department of Paediatric Gastroenterology and Nutrition and Paediatric Neurology of Bangabandhu Sheikh Mujib Medical university (BSMMU ) Dhaka, Bangladesh. Blood samples of 30 consecutive cases of DS were taken for estimation of tissue transglutaminase (IgA) level and clinical features of all positive cases were also recorded.Result : Tissue transglutaminase (tTG) was detected in 10% cases of studied Down’s syndrome children. One third of patients, who had CD, had growth failure. Common features of associated CD cases were dirrhoea, vomiting and abdominal pain.Conclusion : Celiac disease was found in 10% of the studied cases of Down’s syndrome in the present study. Serological tests for celiac disease could be performed in all cases of Down’s syndrome whether it would be symptomatic or asymptomaticNorthern International Medical College Journal Vol.9(1) July 2017: 271-273


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