Effects of juvenile hormone, ecdysteroids and nutrition on larval hemolymph protein gene expression in Galleria mellonella

1987 ◽  
Vol 17 (7) ◽  
pp. 1053-1058 ◽  
Author(s):  
A. Krishna Kumaran ◽  
Aparna Ray ◽  
Jack A. Tertadian ◽  
Nancy A. Memmel
1987 ◽  
Vol 196 (7) ◽  
pp. 414-420 ◽  
Author(s):  
Aparna Ray ◽  
Nancy Ann Memmel ◽  
Alapati Krishna Kumaran

2005 ◽  
Vol 35 (3) ◽  
pp. 207-215 ◽  
Author(s):  
Michael E. Scharf ◽  
Catina R. Ratliff ◽  
Dancia Wu-Scharf ◽  
Xuguo Zhou ◽  
Barry R. Pittendrigh ◽  
...  

2010 ◽  
Vol 34 (8) ◽  
pp. S27-S27
Author(s):  
Jianqi Cui ◽  
Xiuying Pei ◽  
Qian Zhang ◽  
Bassel E. Sawaya ◽  
Xiaohong Lu ◽  
...  

1990 ◽  
Vol 265 (34) ◽  
pp. 21375-21380
Author(s):  
L Wood ◽  
M Mills ◽  
N Hatzenbuhler ◽  
G Vogeli

2021 ◽  
Vol 22 (3) ◽  
pp. 1068
Author(s):  
Katarzyna Dominika Kania ◽  
Waldemar Wagner ◽  
Łukasz Pułaski

Two immortalized brain microvascular endothelial cell lines (hCMEC/D3 and RBE4, of human and rat origin, respectively) were applied as an in vitro model of cellular elements of the blood–brain barrier in a nanotoxicological study. We evaluated the impact of CdSe/ZnS core-shell-type quantum dot nanoparticles on cellular homeostasis, using gold nanoparticles as a largely bioorthogonal control. While the investigated nanoparticles had surprisingly negligible acute cytotoxicity in the evaluated models, a multi-faceted study of barrier-related phenotypes and cell condition revealed a complex pattern of homeostasis disruption. Interestingly, some features of the paracellular barrier phenotype (transendothelial electrical resistance, tight junction protein gene expression) were improved by exposure to nanoparticles in a potential hormetic mechanism. However, mitochondrial potential and antioxidant defences largely collapsed under these conditions, paralleled by a strong pro-apoptotic shift in a significant proportion of cells (evidenced by apoptotic protein gene expression, chromosomal DNA fragmentation, and membrane phosphatidylserine exposure). Taken together, our results suggest a reactive oxygen species-mediated cellular mechanism of blood–brain barrier damage by quantum dots, which may be toxicologically significant in the face of increasing human exposure to this type of nanoparticles, both intended (in medical applications) and more often unintended (from consumer goods-derived environmental pollution).


Sign in / Sign up

Export Citation Format

Share Document