Oestrogen receptors in the rat adrenal gland

1978 ◽  
Vol 9 (10) ◽  
pp. 957-962 ◽  
Author(s):  
R.S. Calandra ◽  
O. Naess ◽  
K. Purvis ◽  
A. Attramadal ◽  
O. Djøseland ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Oestrogen Receptors

Immunolocalisation of oestrogen receptors alpha (ERα) and beta (ERβ) in porcine embryos and fetuses at different stages of gestation

2008 ◽  
Vol 56 (2) ◽  
pp. 221-233 ◽  
Author(s):  
Katarzyna Knapczyk ◽  
Malgorzata Duda ◽  
Bozena Szafranska ◽  
Katarzyna Wolsza ◽  
Grzegorz Panasiewicz ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Stromal Cells ◽  
Adrenal Glands ◽  
Surface Epithelium ◽  
Luminal Epithelium ◽  
Oestrogen Receptors ◽  
Efferent Ductules ◽  
Fetal Organs ◽  
Umbilical Cords ◽  
Porcine Tissues

The sites of oestrogen action can be shown by the localisation of their receptors in the target tissues. The aim of the present study was to show the localisation of oestrogen receptors in porcine embryos and fetuses obtained on days 18, 22, 32, 40, 50, 60, 71 and 90 post coitum (p.c.). The visualisation of proteins was conducted in embryos and various fetal organs such as gonads, uterus, lung, kidney, intestine and adrenal gland. Both ERs were observed in the blastocysts on day 18 p.c. In the male, ERβ was detected in the testis and epididymis, whereas ERα was present in the efferent ductules. In the female, ERβ was detected in the ovarian stromal cells investing the oocyte nests, while ERα protein was detected in the surface epithelium. In the uterus, ERs were present in the stromal cells, while ERβ was present in the luminal epithelium. In the non-reproductive fetal porcine tissues ERβ was localised in the lungs, kidneys, adrenal glands and in the umbilical cords. Both ERs were observed in the intestine. It is possible that ERβ may play important roles in the development of the adrenal gland, testis, kidney and lungs, while both ERs are involved in the development of the ovary, uterus, epididymis and intestine of the porcine fetus.

Role of adrenal gland hormones in the anti-inflammatory effect mechanism of tamoxifen, a partial antagonist for oestrogen receptors, and relation with COX levels

2010 ◽  
Vol 27 (4) ◽  
pp. 241-247 ◽  
Author(s):  
Suleyman Salman ◽  
Serkan Kumbasar ◽  
Yakup Kumtepe ◽  
Mehmet Karaca ◽  
Bunyamin Borekci ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Oestrogen Receptors ◽  
Effect Mechanism ◽  
Anti Inflammatory ◽  
Inflammatory Effect

UPTAKE AND LOSS OF TRITIATED OESTRADIOL BY THE ADRENAL GLAND AND BY OESTROGEN-INDUCED ADRENOCORTICAL CARCINOMA IN THE RAT

1970 ◽  
Vol 48 (4) ◽  
pp. 545-552 ◽  
Author(s):  
BETTY G. MOBBS
Keyword(s):  
Skeletal Muscle ◽  
Adrenal Gland ◽  
Adrenocortical Carcinoma ◽  
The Other ◽  
Oestrogen Receptors ◽  
Tumour Bearing ◽  
Adrenal Tissue ◽  
Target Organs ◽  
Endocrine Status

SUMMARY The loss of injected tritiated oestradiol from the adrenals of non-tumour-bearing rats of different endocrine status and from the adrenals and tumours of animals bearing two lines of transplantable oestrone-induced adrenocortical carcinoma has been studied. There was no evidence that adrenals from non-tumour-bearing rats behaved as 'target organs' for oestrogen as regards retention of the hormone. As compared with skeletal muscle of the same animals, one tumour line and the host adrenals behaved in a similar way to normal adrenals and did not retain oestradiol, whereas the other tumour line and host adrenals lost the hormone at a somewhat slower rate than muscle. It is suggested that the behaviour of the host adrenals and of the transplanted tumours regarding the injected oestrogen was determined more by the hormonal environment of the tissues including the contribution made by the tumour itself, than by specific oestrogen receptors in adrenal tissue.

Adrenal glands alter the concentration of oestradiol-17β and its receptor in the uterus of ovariectomized ewes

1988 ◽  
Vol 118 (3) ◽  
pp. 375-380 ◽  
Author(s):  
S. Atkinson ◽  
N. R. Adams
Keyword(s):  
Drug Therapy ◽  
Adrenal Gland ◽  
Replacement Therapy ◽  
Plasma Glucose ◽  
Adrenal Glands ◽  
Oestrogen Receptors ◽  
Tissue Concentrations ◽  
Blood Samples ◽  
Adrenal Hormones

ABSTRACT To investigate the effects of adrenal hormones on oestrogen activity in the uterus, ovariectomized ewes were either adrenalectomized, administered glucocorticoid-like preparations (CORT), or remained as controls. The adrenalectomized ewes were maintained with a corticoid-replacement therapy and monitored daily for plasma glucose and Na+/K+ concentrations. Blood samples were collected from all ewes at 15-min intervals for 4 h and assayed for LH and FSH. The adrenalectomized ewes were killed 9 days after adrenalectomy, while the CORT ewes were killed after 3 weeks of drug therapy. The control ewes were killed simultaneously with the CORT ewes. Uterine tissues were homogenized and the numbers of oestradiol receptors and tissue concentrations of oestradiol-17β were measured. The adrenalectomized ewes had significantly higher concentrations of cytosolic oestrogen receptors in the uterus than did the control ewes, which had significantly higher concentrations than the CORT ewes (0·95±0·06, 0·76 ± 0·02 and 0·60±0·02 (s.e.m.) μmol/kg protein respectively). The concentrations of oestradiol-17β measured in uterine tissues were significantly lower in adrenalectomized and CORT ewes than in control ewes (37·4±5·5, 61·7±25·7 and 135·5 ± 12·8 pmol/kg respectively). There were no significant differences between any groups in the peripheral concentrations of LH or FSH. These results indicate that the adrenal gland affects the concentrations of both oestrogen and its receptor in the uterus of ovariectomized ewes, probably by different mechanisms. These effects are not mediated by gonadotrophins. J. Endocr. (1988) 118, 375–380

Ultrastructural Cytopiasmic Changes of Adrenal Cortex During Pregnancy

1969 ◽  
Vol 27 ◽  
pp. 298-299
Author(s):  
T. M. Murad ◽  
Karen Israel ◽  
Jack C. Geer
Keyword(s):  
Adrenal Gland ◽  
Steroid Hormones ◽  
Adrenal Cortex ◽  
Lipid Droplets ◽  
Plasma Cholesterol ◽  
Adrenal Steroids ◽  
Dynamic Changes ◽  
Cortical Cells ◽  
Acetyl Coenzyme A ◽  
Adrenal Cortical Cells

Adrenal steroids are normally synthesized from acetyl coenzyme A via cholesterol. Cholesterol is also shown to enter the adrenal gland and to be localized in the lipid droplets of the adrenal cortical cells. Both pregnenolone and progesterone act as intermediates in the conversion of cholesterol into steroid hormones. During pregnancy an increased level of plasma cholesterol is known to be associated with an increase of the adrenal corticoid and progesterone. The present study is designed to demonstrate whether the adrenal cortical cells show any dynamic changes during pregnancy.

An adrenocortical oncocytoma with unusual mitochondrial inclusions and cytoplasmic crystals

1994 ◽  
Vol 52 ◽  
pp. 250-251
Author(s):  
W.T. Gunning ◽  
G.D. Haselhuhn ◽  
E.R. Phillips ◽  
S.H. Selman
Keyword(s):  
Adrenal Gland ◽  
Salivary Glands ◽  
Mitotic Activity ◽  
Diagnostic Criteria ◽  
Vascular Invasion ◽  
Benign Neoplasm ◽  
Benign Tumors ◽  
Nuclear Morphology ◽  
Case Presentation ◽  
Microscopic Evidence

Within the last few years, adrenal cortical tumors with features concordant with the diagnostic criteria attributed to oncocytomas have been reported. To date, only nine reported cases exist in the literature. This report is the tenth case presentation of a presumptively benign neoplasm of the adrenal gland with a rare differentiation. Oncocytomas are well recognized benign tumors of the thyroid, parathyroid, and salivary glands and of the kidney. Other organs also give rise to these types of tumors, however with less frequency than the former sites. The characteristics generally used to classify a tumor as an oncocytoma include the following criteria: the tumor is 1) usually a solitary circumscribed mass with no gross nor microscopic evidence of metastasis (no tissue nor vascular invasion), 2) fairly bland in terms of mitotic activity and nuclear morphology, and 3) composed of large eosinophillic cells in which the cytoplasm is packed full of mitochondria (Figure 1).

Nuclear receptors in disease: the oestrogen receptors

2004 ◽  
Vol 40 ◽  
pp. 157-167 ◽  
Author(s):  
Maria Nilsson ◽  
Karin Dahlman-Wright ◽  
Jan-Åke Gustafsson
Keyword(s):  
Nuclear Receptors ◽  
Target Genes ◽  
Receptor Subtype ◽  
Target Tissue ◽  
Oestrogen Receptors ◽  
Nucleotide Polymorphisms ◽  
Cell Type ◽  
Single Nucleotide ◽  
Beneficial Effects ◽  
The Family

For several decades, it has been known that oestrogens are essential for human health. The discovery that there are two oestrogen receptors (ERs), ERalpha and ERbeta, has facilitated our understanding of how the hormone exerts its physiological effects. The ERs belong to the family of ligand-activated nuclear receptors, which act by modulating the expression of target genes. Studies of ER-knockout (ERKO) mice have been instrumental in defining the relevance of a given receptor subtype in a certain tissue. Phenotypes displayed by ERKO mice suggest diseases in which dysfunctional ERs might be involved in aetiology and pathology. Association between single-nucleotide polymorphisms (SNPs) in ER genes and disease have been demonstrated in several cases. Selective ER modulators (SERMs), which are selective with regard to their effects in a certain cell type, already exist. Since oestrogen has effects in many tissues, the goal with a SERM is to provide beneficial effects in one target tissue while avoiding side effects in others. Refined SERMs will, in the future, provide improved therapeutic strategies for existing and novel indications.

Contribution of Adrenaline to the Fibrinolytic Activity Evoked by E. Coli Endotoxin in the Rat

1983 ◽  
Vol 50 (02) ◽  
pp. 557-559 ◽  
Author(s):  
J F Fracasso ◽  
A M Rothschild
Keyword(s):  
Fatty Acid ◽  
Adrenal Gland ◽  
Intravenous Injection ◽  
Fibrinolytic Activity ◽  
Blocking Agent ◽  
E Coli ◽  
Adrenergic Blocking

SummaryIntravenous injection of E. coli endotoxin (ETX), of adrenaline (AD) or of carbamylcholine (CBCH), caused fibrinolytic activity (FA), directly detectable on plasminogen-rich fibrin plates, to appear in the plasma of the rat. Adrenodemedul- lation abolished responses to ETX or CBCH, but enhanced those to AD. Rats given ETX exhibited marked hypotension, followed by a compensatory phase of normotension abolished by adrenodemedullation and significantly attenuated by phenoxy- benzamine, an a-adrenergic blocking agent which however failed to block FA caused by either ETX or AD. Aspirin, but not indomethacin, inhibited FA evoked by ETX, AD or CBCH. These results suggest that FA evoked by ETX in the rat is caused by AD released from the adrenal gland and does involve the fatty acid cyclooxygenase system.

Sign in / Sign up

Export Citation Format

Share Document