A study of plasma free amino acid levels. V. Correlations among the amino acids and between amino acids and some other blood constituents

Metabolism ◽  
1973 ◽  
Vol 22 (6) ◽  
pp. 827-833 ◽  
Author(s):  
Marvin D. Armstrong ◽  
Uwe Stave
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Free Amino ◽  
Blood Constituents ◽  
Amino Acid Levels

EFFECT OF CORTISOL TREATMENT ON FREE AMINO ACID LEVELS IN RATS

1973 ◽  
Vol 59 (1) ◽  
pp. 57-63 ◽  
Author(s):  
W. DE LOECKER ◽  
M. L. STAS
Keyword(s):  
Skeletal Muscle ◽  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Protein Turnover ◽  
Free Amino Acids ◽  
Free Amino ◽  
Experimental Period ◽  
Amino Acid Levels ◽  
Amino Acid Concentrations

SUMMARY Changes in the concentrations of free amino acids in intracellular fluids and blood plasma were measured in rats treated with cortisol. Increasing age raised the concentrations of free amino acids in plasma, while in liver, with the exception of glycine and alanine, decreased concentrations were observed. Cortisol treatment reduced free amino acid levels in plasma and liver which suggested a progressive catabolism of body proteins and increased protein synthesis in the liver. In skeletal muscle of control rats the free amino acid concentrations increased during the experimental period. Cortisol increased the concentration of certain amino acids and decreased that of others due to an increased protein turnover in muscle.

Comparison of fasting plasma amino acid patterns in the pig, rat, and chicken

1969 ◽  
Vol 47 (4) ◽  
pp. 392-395 ◽  
Author(s):  
John Boomgaardt ◽  
Bruce E. McDonald
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Free Amino ◽  
Avian Species ◽  
Plasma Amino Acid ◽  
Fasting Plasma ◽  
Lysine Concentration ◽  
Amino Acid Levels

Comparison of free amino acid levels in plasma (PAA) at 8, 12, 16, 20, and 24 h postprandial in pigs, rats, and chickens revealed differences between mammalian and avian species in the fasting metabolism of amino acids. PAA patterns during fasting were more variable for chickens than for either rats or pigs. There was a marked increase in the plasma lysine level in chickens (27.5 to 115.8 μg/ml) as fasting was extended from 8 to 24 h. Plasma lysine levels in pigs and rats, by contrast, increased from 14.2 to 19.5 μg/ml and 39.8 to 63.7 μg/ml respectively during the same period of fast. Plasma threonine and methionine levels also increased in chickens during fasting whereas the levels of these amino acids in pigs and rats decreased or remained unchanged during a 24-h fast. Extending the period of fast to 36 h in chickens and 48 h in pigs resulted in further small increases in the plasma lysine concentration.

scholarly journals Platelet Amino Acid Levels in Essential Thrombocytosis

Blood ◽  
1966 ◽  
Vol 27 (5) ◽  
pp. 715-721 ◽  
Author(s):  
RALPH L. NACHMAN ◽  
HERBERT I. HOROWITZ ◽  
RICHARD T. SILVER
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Free Amino ◽  
Essential Thrombocytosis ◽  
Amino Acid Levels

Abstract Studies on the platelets from three patients with essential thrombocytosis were presented. The intraplatelet free amino acid levels were elevated and the pseudo-hyperkalemic phenomenon was present. In one subject the pseudohyperkalemic phenomenon was reversed after a therapeutic remission, but the elevation of amino acids persisted. The data suggest that a qualitative abnormality may exist in the platelets of patients with essential thrombocytosis.

The Stability of the Free Amino Acid Pool in Isolated Peripheral Nerves of Carcinus Maenas (L.)

1973 ◽  
Vol 59 (2) ◽  
pp. 463-476
Author(s):  
P. D. EVANS
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Peripheral Nerves ◽  
Free Amino ◽  
Slow Component ◽  
Carcinus Maenas ◽  
Neuronal Membranes ◽  
Amino Acid Levels ◽  
The Stability

1. Isolated peripheral nerves of Carcinus maenas (L.) were capable of maintaining their free amino acid levels steady for the first hour of incubation in saline. 2. The addition of a presumed blood concentration of D-glucose (7.2 mg/100 ml) caused a rapid drop in the amino acid levels, whereas incubation in actual fresh samples of blood did not. It is possible therefore that much of the glucose in crab blood might be effectively sequestered into the haemocyte fraction. 3. It is suggested that metabolism might play an important part in the maintenance of the very steep free amino acid concentration gradients across the neuronal membranes of this species. 4. The efflux of amino acids from this tissue is complex. It consists of a slow component (T0.5 = 77.7 min) and a fast component (T0.5 = 3.1 min) which account for about 50% and 40% respectively of the total intracellular radioactivity accumulated after a 20 min incubation. 5. In experiments where the nerves retained connexion with the thoracic ganglion, the levels of amino acids were higher than in controls which were isolated from the ganglion by a ligature. The possible significance of these findings is discussed.

scholarly journals The variation in amino acid levels in the blood plasma of breeding roosters during sexual maturation*

2002 ◽  
Vol 45 (3) ◽  
pp. 279-285
Author(s):  
E. Straková ◽  
P. Suchý ◽  
V. Večerek ◽  
L. Máchal
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Blood Plasma ◽  
Free Amino Acid ◽  
Sexual Maturation ◽  
Free Amino Acids ◽  
Free Amino ◽  
Molar Concentration ◽  
Dynamic Changes ◽  
Amino Acid Levels

Abstract. The paper provides an overview of results obtained in the study of variation in free amino acid levels in the blood plasma of breeding roosters (RIR 05 line) during sexual maturation (in the 10th, 15th, 20th and 25th weeks of age). The results prove that dynamic changes in free amino acid concentrations in blood plasma are connected with the sexual maturation of breeding roosters. During this period the concentrations of each particular free amino acid varied at a significance level of P ≤ 0.05 and P ≤ 0.01. Furthermore, in most cases the plasma concentrations of free amino acids in the 10th and 15th week were higher in comparison with those in the 20th and 25th week. Interestingly, the concentrations of individual free amino acids ranged over a wide interval (units, tens and hundreds of μmol/l). In this respect the free amino acids in plasma can be divided into three groups. The first group consisted of amino acids that occurred at low molar concentration (up to 100 μmol/l): cysteic acid, aspartic acid, α-aminoadipic acid, methionine, isoleucine, γ-aminobutyric acid, 3-methylhistidine, tryptophan and ornitine. The second group included amino acids occurring at medium to high molar concentration (100–300 μmol/l): taurine, glutamine, 1/2 cystine, valine, leucine, tyrosine, phenylalanine, histidine, lysine and arginine. Finally, the third group contained threonine, serine, glutamic acid, proline, glycine and alanine that were present at high molar concentrations (above 300 μmol/l). Analyses of plasma in the period from the 10th to 25th week detected dynamic changes in levels of individual free amino acids and showed that the total content of these amino acids gradually decreased to the following mean values: 5 685.00 μmol/l in the 10th week, 5 076.21 μmol/l in the 15th week, 4 384.78 μmol/l in the 20th week and 4 793.30 μmol/l in the 25th week.

Plasma-Free Amino Acid Profiling of Nasal Polyposis Patients

2020 ◽  
Vol 22 (9) ◽  
pp. 657-662 ◽  
Author(s):  
Mustafa Celik ◽  
Alper Şen ◽  
İsmail Koyuncu ◽  
Ataman Gönel
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acid ◽  
Free Amino ◽  
Nasal Polyposis ◽  
Amino Acid Profile ◽  
Healthy Control Group ◽  
Control Group ◽  
Healthy Control ◽  
History Of

Aim and Objective:: To determine the mechanisms present in the etiopathogenesis of nasal polyposis. It is not clear whether amino acids contribute in a causal way to the development of the disease. Therefore, the aim of this study was to determine the plasma-free amino acid profile in patients with nasal polyposis and to compare the results with a healthy control group. Materials and Methods:: This was a prospective controlled study that took place in the Otolaryngology Department at the Harran University Faculty of Medicine between April 2017 and April 2018. Plasmafree amino acid profile levels were studied in serum samples taken from a patient group and a healthy control group. Patients who were diagnosed with bilateral diffuse nasal polyposis and were scheduled for surgical interventions were included in this study. Individuals whose age, gender, and body mass index values were compatible with that of the patient group and who did not have any health problems were included in the control group. All the participants whose levels of plasma-free amino acid were thought to be affected by one or more of the following factors were excluded from the study: smoking and alcohol use, allergic rhinitis presence, the presence of acute or chronic sinusitis, a history of endoscopic sinus surgery, unilateral nasal masses, a history of chronic drug use, systemic or topical steroid use in the last three months for any reason, and liver, kidney, hematological, cardiovascular, metabolic, neurological, or psychiatric disorders or malignancies. Results: In patients with nasal polyposis, 3-methyl histidine (3-MHIS: nasal polyposis group (ng) = 3.22 (1.92 – 6.07); control group (cg) = 1.21 (0.77 – 1.68); p = 0.001); arginine (arg: ng = 98.95 (70.81 – 117.75); cg = 75.10 (54.49 – 79.88); p = 0.005); asparagine (asn: ng = 79.84 (57.50 – 101.44); cg = 60.66 (46.39 – 74.62); p = 0.021); citrulline (cit: ng = 51.83 (43.81 – 59.78); cg = 38.33 (27.81 – 53.73); p = 0.038); cystine (cys: ng = 4.29 (2.43 – 6.66); cg = 2.41 (1.51 – 4.16); p = 0.019); glutamic acid (glu: ng = 234.86 (128.75 – 286.66); cg = 152.37 (122.51 – 188.34); p = 0.045); histidine (his: ng = 94.19 (79.34 – 113.99); cg = 74.80 (62.76 – 98.91); p = 0.018); lysine (lys: ng = 297.22 (206.55 – 371.25); cg = 179.50 (151.58 – 238.02); p = 0.001); ornithine (ng = 160.62 (128.36 – 189.32); cg = 115.91 (97.03 – 159.91); p = 0.019); serine (ser: ng = 195.15 (151.58 – 253.07); cg = 83.07 (67.44 – 92.44); p = 0.001); taurine (tau: ng = 74.69 (47.00 – 112.13); cg = 53.14 (33.57 – 67.31); p = 0.006); tryptophan (trp: ng = 52.31 (33.81 – 80.11); cg = 34.44 (25.94 – 43.07); p = 0.005), homocitrulline (ng = 1.75 (1.27 – 2.59); cg = 0.00 (0.00 – 0.53); p = 0.001); norvaline (ng = 6.90 (5.61 – 9.18); cg = 4.93 (3.74 – 7.13); p = 0.021); argininosuccinic acid (ng = 14.33 (10.06 – 25.65); cg = 12.22 (5.77 – 16.87) p = 0.046); and plasma concentrations were significantly higher than in the healthy control group (p <0.05). However, the gamma-aminobutyric acid (gaba: ng = 0.16 (0.10 – 0.24); cg = 0.21 (0.19 – 0.29); p = 0.010) plasma concentration was significantly lower in the nasal polyposis group than in the healthy control group. Conclusion: In this study, plasma levels of 15 free amino acids were significantly higher in the nasal polyposis group than in the healthy control group. A plasma level of 1 free amino acid was found to be significantly lower in the nasal polyposis group compared to the healthy control group. Therefore, it is important to determine the possibility of using the information obtained to prevent the recurrence of the condition and to develop effective treatment strategies. This study may be a milestone for studies of this subject. However, this study needs to be confirmed by further studies conducted in a larger series.

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