Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation

The aim of the present study was to evaluate the effects of diets enriched in monounsaturated fatty acids (MUFA) (olive oil) or MUFA plus n-3 polyunsaturated fatty acids (PUFA) (olive oil plus fish oil), associated with an intervention program that focused on lifestyle habits, physical performance, plasma lipids, and lipoprotein composition in patients with peripheral vascular disease (PVD). A 15-month longitudinal nutritional and lifestyle intervention study was carried out with 24 free-living male patients aged 58.0 ± 2.2 years diagnosed with PVD (Fontaine grade II). The patients were clinically evaluated and counseled to change their dietary and lifestyle habits for six months, after this period they consumed an olive oil-based diet for three months; after a three-month wash-out period, their diet was supplemented with a combination of fish oil and olive oil for the final three months. Lifestyle interventions resulted in a significant decrease in cigarette smoking and an increase in physical activity. Claudicometry was lower at the end of the study than at the beginning. Intake of the fish oil supplement led to significant changes in lipid lipoprotein composition, decreasing low-density lipoprotein (LDL) cholesterol. The lifestyle intervention program, together with a high intake of olive plus fish oil, seems to produce important beneficial effects in nutritional management, physical performance, and clinical parameters of PVD patients.

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Effects of Seal Oil and Tuna-Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

Lipids ◽

10.1007/s11745-010-3450-z ◽

2010 ◽

Vol 45 (8) ◽

pp. 669-681 ◽

Cited By ~ 35

Author(s):

Neil J. Mann ◽

Stella L. O’Connell ◽

Kylie M. Baldwin ◽

Indu Singh ◽

Barbara J. Meyer

Keyword(s):

Fish Oil ◽

Healthy Subjects ◽

Plasma Lipid ◽

Lipid Levels ◽

Tuna Fish ◽

Seal Oil ◽

Tuna Fish Oil

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Effects of two “lipid-lowering” diets on plasma lipid levels of patients with peripheral vascular disease

Journal of the American Dietetic Association ◽

10.1016/s0002-8223(21)08198-0 ◽

1984 ◽

Vol 84 (5) ◽

pp. 546-550

Author(s):

G.D. Brown ◽

L. Whyte ◽

M.I. Gee ◽

P.M. Crockford ◽

M. Grace ◽

...

Keyword(s):

Vascular Disease ◽

Peripheral Vascular Disease ◽

Plasma Lipid ◽

Lipid Lowering ◽

Lipid Levels ◽

Peripheral Vascular

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n − 3 Fatty acid supplementation during pregnancy in women with allergic disease: effects on blood pressure, and maternal and fetal lipids

Clinical Science ◽

10.1042/cs20060096 ◽

2006 ◽

Vol 111 (4) ◽

pp. 289-294 ◽

Cited By ~ 17

Author(s):

Anne E. Barden ◽

Janet A. Dunstan ◽

Lawrence J. Beilin ◽

Susan L. Prescott ◽

Trevor A. Mori

Keyword(s):

Blood Pressure ◽

Fatty Acid ◽

Fish Oil ◽

Olive Oil ◽

Total Cholesterol ◽

Allergic Disease ◽

Density Lipoprotein ◽

Lipid Levels ◽

Fatty Acid Supplementation ◽

Fish Oil Supplementation

n−3 Fatty acids derived from fish oil reduce plasma triacylglycerols (triglycerides) and increase HDL-C (high-density lipoprotein cholesterol); however, the effect of n−3 fatty acid supplementation during pregnancy, a hyperlipidaemic state, remains unknown. We took the opportunity to investigate maternal lipid levels and blood pressure during and after pregnancy, and fetal lipid levels at birth, in a study that aimed primarily to examine the effect of fish oil supplementation during pregnancy on immune function in infants born to women with allergic disease. Eighty-three pregnant women who had allergic disease, but were otherwise healthy, completed the study. They were randomly allocated to receive fish oil or olive oil capsules, taken as 4 g/day, from 20 weeks of pregnancy until delivery. Compared with olive oil, fish oil supplementation did not alter triacylglycerols, total cholesterol, LDL-C (low-density lipoprotein cholesterol) or HDL-C during or after pregnancy. There was also no effect of fish oil on cord blood triacylglycerols, total cholesterol, LDL-C or HDL-C. Fish oil supplementation during pregnancy did not alter maternal blood pressure during or after pregnancy. The effects of fish oil on lipids and blood pressure in non-pregnant individuals appear to be lost when it is administered during pregnancy.

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Influence of APOE-2 genotype on the relation between adiposity and plasma lipid levels in patients with vascular disease

International Journal of Obesity ◽

10.1038/ijo.2014.105 ◽

2014 ◽

Vol 39 (2) ◽

pp. 265-269 ◽

Cited By ~ 13

Author(s):

C Koopal ◽

◽

Y van der Graaf ◽

F W Asselbergs ◽

J Westerink ◽

...

Keyword(s):

Vascular Disease ◽

Plasma Lipid ◽

Lipid Levels

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Olive oil- and fish oil-enriched diets modify plasma lipids and susceptibility of LDL to oxidative modification in free-living male patients with peripheral vascular disease: the Spanish Nutrition Study

British Journal Of Nutrition ◽

10.1017/s0007114599001099 ◽

1999 ◽

Vol 82 (1) ◽

pp. 31-39 ◽

Cited By ~ 38

Author(s):

Carmen Ramírez-Tortosa ◽

Jose M. López-Pedrosa ◽

Antonio Suarez ◽

Eduardo Ros ◽

José Mataix ◽

...

Keyword(s):

Fish Oil ◽

Olive Oil ◽

Vascular Disease ◽

Peripheral Vascular Disease ◽

Dietary Intervention ◽

Plasma Lipids ◽

Reference Group ◽

Oxidative Modification ◽

Control Group ◽

Peripheral Vascular

The present study describes a clinical trial in which Spanish patients suffering from peripheral vascular disease (Fontaine stage II) were given specific lipid supplements. Designed as a longitudinal intervention study, patients were provided with olive oil for 3 months, followed by a 3 month wash-out period, then supplemented with a combination of fish oil and olive oil for the final 3 months. Changes in plasma and lipoprotein fatty acid composition and susceptibility of LDL toin vitrooxidation were examined. Furthermore, lipid-supplement-induced changes in LDL properties were measured as relative electrophoretic mobility and macrophage uptake. In addition, thirteen patients not provided with olive oil and fish oil were included as a control group and twenty healthy age-matched individuals were used as a reference group. A complete clinical study and a nutritional survey concerning food habits and lifestyle were performed every 3 months. Yao indices and claudicometry did not change significantly with dietary intervention although changes in plasma lipid composition suggested an improvement in the condition of the patients. The intake of the fish-oil supplement resulted in significantly increased plasma levels of eicosapentaenoic acid (20:5n−3) and docosahexaenoic acid (22:6n−3) in comparison with baseline concentrations, olive-oil and control groups. Fish-oil consumption significantly decreased plasma triacylglycerol levels compared with the olive-oil period, control and reference groups. The susceptibility of LDL to Cu-mediated oxidation was lower in the patients consuming olive oil and the fish-oil supplement than in the control group, and the uptake of LDL by macrophages was significantly lower in the group supplemented with fish oil. In conclusion, consumption of olive oil together with a dietary supplement of fish oil may be useful in the nutritional management of patients suffering from peripheral vascular disease in terms of increasing plasman−3 long-chain polyunsaturated fatty acids and decreasing susceptibility of LDL to oxidation.

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