Effect on experimental animals of long-term inhalation exposure to mineral spirits II. Dietary, sex and strain influences in guinea pigs

1971 ◽  
Vol 18 (1) ◽  
pp. 53-59 ◽  
Author(s):  
L.J. Jenkins ◽  
R.A. Coon ◽  
J.P. Lyon ◽  
J. Siegel
Keyword(s):  
Guinea Pigs ◽  
Inhalation Exposure ◽  
Experimental Animals ◽  
Mineral Spirits

Effects on experimental animals of long-term inhalation exposure to mineral spirits

1966 ◽  
Vol 9 (2) ◽  
pp. 257-268 ◽  
Author(s):  
D.E. Rector ◽  
B.L. Steadman ◽  
R.A. Jones ◽  
J. Siegel
Keyword(s):  
Inhalation Exposure ◽  
Experimental Animals ◽  
Mineral Spirits

scholarly journals Analysis of Aflatoxin Biomarkers in the Hair of Experimental Animals

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 570
Author(s):  
Innocent Mupunga ◽  
Ilse Janse van Rensburg ◽  
Nokuthula Luthuli ◽  
Ovokeroye A. Abafe ◽  
Leshweni J. Shai ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Hair Analysis ◽  
Historical Record ◽  
Body Fluids ◽  
Urine Samples ◽  
Long Term Effects ◽  
Experimental Animals ◽  
Explorative Study ◽  
Hair Samples

Analysis of body fluids and tissues of aflatoxin exposed individuals for the presence of aflatoxins and aflatoxin metabolites has emerged as a reliable indicator of exposure and metabolism of aflatoxins. However, current aflatoxin biomarkers are not appropriate for investigating the long-term effects of aflatoxin exposure. In this explorative study, we investigated the analysis of hair as a complementary or alternative matrix for the assessment of biomarkers of long-term aflatoxin exposure. Three groups of guinea pigs were orally dosed with 5 ugkg−1bw−1, 50 ugkg−1bw−1, and 100 ugkg−1bw−1 of AFB1. Urine and hair samples were collected on days 0, 1, 2, 3, 7, 30, 60, and 90 and analysed for AFB1 and AFM1 using UHPLC-MS/MS. AFB1 and AFM1 were detected in 75% and 13.6%, respectively, of the day 1 to day 7 urine samples. AFB1 was detected in hair samples collected from day 3 up to day 60. This is the first report to confirm the deposition of AFB1 in the hair of experimental animals. These findings indicate that hair analysis has the potential to provide an accurate long-term historical record of aflatoxin exposure with potentially important implications for the field of aflatoxin biomarkers.

Effects on experimental animals of long-term inhalation exposure to carbon monoxide

1971 ◽  
Vol 19 (1) ◽  
pp. 46-53 ◽  
Author(s):  
R.A. Jones ◽  
J.A. Strickland ◽  
J.A. Stunkard ◽  
J. Siegel
Keyword(s):  
Carbon Monoxide ◽  
Inhalation Exposure ◽  
Experimental Animals

scholarly journals MORPHOLOGICAL FEATURES OF LUNG STRUCTURE AND FUNCTIONAL ACTIVITY OF THE AIRWAYS OF GUINEA PIGS AFTER LONG-TERM EXPOSURE WITH NANOSIZED MAGNETITE A

2013 ◽  
Vol 12 (1) ◽  
pp. 7-13
Author(s):  
Ye. Ye. Abramenko ◽  
A. V. Nosarev ◽  
L. V. Smaglyi ◽  
L. V. Kapilevich ◽  
Ye. Yu. D’yakova ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Functional Status ◽  
Functional Activity ◽  
Guinea Pigs ◽  
Morphological Features ◽  
Histological Structure ◽  
Experimental Animals ◽  
Lung Structure ◽  
Nanosized Magnetite

The results of study, in which we examined the influence of nanosized magnetite on breath organs histological structure and contractility activity of the airways of guinea pigs by method of mechanography has been presented. In the lungs of experimental animals an inflammatory response developed as a result of long-term inhalation intake of nanosized magnetite. Also the functional status of the airways changed and appeared as changing of amplitude of contractility response under the action of histamine.

A COMPARISON BETWEEN THE EXOPHTHALMOS INHIBITING EFFECTS OF SODIUM-D- AND SODIUM-L-THYROXINE IN GUINEA PIGS

1962 ◽  
Vol 41 (4) ◽  
pp. 619-624 ◽  
Author(s):  
Björn Tengroth ◽  
Uno Zackrisson
Keyword(s):  
Hyaluronic Acid ◽  
Pituitary Gland ◽  
Guinea Pigs ◽  
Anterior Lobe ◽  
Optical Isomers ◽  
Connective Tissues ◽  
Response Curves ◽  
Experimental Animals ◽  
Inhibiting Effect ◽  
Caloric Effect

ABSTRACT The general change in the connective tissues which occurs in animals with experimentally produced exophthalmos, consists in an increase in the amount of hyaluronic acid, which binds the water in the connective tissue. Many regard this process as a stimulation of the mucinous system in the connective tissues, and consider this an explanation of the phenomenon of exophthalmos. When the experimental animals are injected with thyroxine or thyroid extract, the reaction observed is opposite to that seen following the injection of the anterior lobe of the pituitary gland. In the former case, there is a reduction in the amount of hyaluronic acid and consequently a decrease in the water content in the connective tissues. In the experiments in question, Na-d-thyroxine and Na-l-thyroxine), in crystalline form, were tested for their inhibiting effect on the development of exophthalmos in experimental animals. The animals used were male albino guinea-pigs. An extract of the anterior lobe of the pituitary gland (TSH Organon)) was used to produce exophthalmos. In previous work (Tengroth 1961), it was shown, using an X-ray measuring technique, that d-thyroxine, despite its poor caloric effect, like l-thyroxine had an exophthalmos-inhibiting effect. When comparing the dose-response curves of the exophthalmos-inhibiting properties of both these optical isomers, it appears that d-thyroxine has an inhibiting effect which is significantly greater than that of l-thyroxine. The significance of this observation is discussed.

scholarly journals Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons

2014 ◽  
Vol 306 (2) ◽  
pp. L170-L182 ◽  
Author(s):  
Anna A. Shvedova ◽  
Naveena Yanamala ◽  
Elena R. Kisin ◽  
Alexey V. Tkach ◽  
Ashley R. Murray ◽  
...  
Keyword(s):  
Lung Tumor ◽  
Inhalation Exposure ◽  
Geometric Feature ◽  
Width Ratio ◽  
Long Term Effects ◽  
Genotoxic Effects ◽  
Pulmonary Exposure ◽  
Pharyngeal Aspiration

The hallmark geometric feature of single-walled carbon nanotubes (SWCNT) and carbon nanofibers (CNF), high length to width ratio, makes them similar to a hazardous agent, asbestos. Very limited data are available concerning long-term effects of pulmonary exposure to SWCNT or CNF. Here, we compared inflammatory, fibrogenic, and genotoxic effects of CNF, SWCNT, or asbestos in mice 1 yr after pharyngeal aspiration. In addition, we compared pulmonary responses to SWCNT by bolus dosing through pharyngeal aspiration and inhalation 5 h/day for 4 days, to evaluate the effect of dose rate. The aspiration studies showed that these particles can be visualized in the lung at 1 yr postexposure, whereas some translocate to lymphatics. All these particles induced chronic bronchopneumonia and lymphadenitis, accompanied by pulmonary fibrosis. CNF and asbestos were found to promote the greatest degree of inflammation, followed by SWCNT, whereas SWCNT were the most fibrogenic of these three particles. Furthermore, SWCNT induced cytogenetic alterations seen as micronuclei formation and nuclear protrusions in vivo. Importantly, inhalation exposure to SWCNT showed significantly greater inflammatory, fibrotic, and genotoxic effects than bolus pharyngeal aspiration. Finally, SWCNT and CNF, but not asbestos exposures, increased the incidence of K-ras oncogene mutations in the lung. No increased lung tumor incidence occurred after 1 yr postexposure to SWCNT, CNF, and asbestos. Overall, our data suggest that long-term pulmonary toxicity of SWCNT, CNF, and asbestos is defined, not only by their chemical composition, but also by the specific surface area and type of exposure.

scholarly journals Long-Term Inhalation Exposure to Nickel Nanoparticles Exacerbated Atherosclerosis in a Susceptible Mouse Model

2011 ◽  
Vol 119 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Gi Soo Kang ◽  
Patricia Anne Gillespie ◽  
Albert Gunnison ◽  
Andre Luis Moreira ◽  
Kam-Meng Tchou-Wong ◽  
...  
Keyword(s):  
Mouse Model ◽  
Nickel Nanoparticles ◽  
Inhalation Exposure ◽  
Susceptible Mouse

scholarly journals EFFECT OF LOCAL UV RADIATION ON THE MORPHOFUNCTIONAL STATE OF THE SKIN OF GUINEA PIGS IN EARLY AND REMOTE PERIODS AFTER IRRADIATION

2020 ◽  
Vol 73 (4) ◽  
pp. 705-707
Author(s):  
Tetyana V. Zvyagintseva ◽  
Svitlana I. Myronchenko ◽  
Nataliia I. Kytsiuk ◽  
Olga V. Naumova
Keyword(s):  
Ultraviolet Irradiation ◽  
Guinea Pigs ◽  
Acute Inflammation ◽  
Elastic Fibers ◽  
Control Group ◽  
Entire Observation Period ◽  
Morphological Picture ◽  
Morphometric Methods ◽  
Observation Period

The aim is to establish the features of morphological and morphometric changes in the skin of guinea pigs in erythemal, early post-erythemal and late post-erythemic periods after local ultraviolet irradiation. Materials and methods: Studies were conducted on 54 albino guinea pigs weighing 400-500 g. Ultraviolet erythema was caused by irradiation in 1 minimum erythemal dose. The control group included intact guinea pigs. After 2, 4 hours, on the 3rd, 8th, 15th, 21st, 28th day, the fragments of the irradiated skin were investigated using histochemical and morphometric methods. Results: After 2, 4 hours after irradiation, dyscirculatory changes in the skin develop. By the 3rd day of the experiment a morphological picture of acute inflammation in the epidermis and dermis develops, apoptotic keratinocytes appear (sunburn cells), which is accompanied by thickening of the epidermis and an increase in the density of fibroblasts. By the 8th day proliferative-hyperplastic and degenerative changes begin to prevail, including dystrophic nature, the thickness of the epidermis and the density of fibroblasts reach a maximum. In the long term, on the 15-28th day, dystrophic changes of the epidermis, dyskeratosis, changes in the number and structure of elastic fibers with an increase in uneven fibrosis, collagenization processes and the development of sclerotic changes, as well as a significant thickening of the epidermis, an increase in the density of fibroblasts are observed. Conclusions: The data obtained indicate pronounced morphofunctional changes in the skin in the zone of local ultraviolet irradiation observed throughout the entire observation period.

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