Impaired clearance, elimination, and metabolism of plasma cholesterol esters associated with hypercholesteremia in mice fed cyclopropenoid fatty acids

1986 ◽  
Vol 84 (1) ◽  
pp. 3-11 ◽  
Author(s):  
John P. Matlock ◽  
J.E. Nixon
Keyword(s):  
Fatty Acids ◽  
Plasma Cholesterol ◽  
Cholesterol Esters ◽  
Cyclopropenoid Fatty Acids

scholarly journals Plasma Cholesterol Ester Fatty Acids: A New Biochemical Abnormality in Obstructive Jaundice

HPB Surgery ◽  
1995 ◽  
Vol 8 (4) ◽  
pp. 241-244
Author(s):  
M. W. Scriven ◽  
D. F. Horrobin ◽  
M. C. A. Puntis
Keyword(s):  
Fatty Acids ◽  
Double Bond ◽  
Obstructive Jaundice ◽  
Plasma Cholesterol ◽  
Essential Fatty Acids ◽  
Cholesterol Esters ◽  
Biochemical Abnormality ◽  
Membrane Function ◽  
Plasma Cholesterol Ester ◽  
Fatty Acid Patterns

Changes in fatty acid patterns may explain many of the observed abnormalities found in obstructive jaundice. This study looked at fatty acids in plasma cholesterol esters, in a group of patients with obstructive jaundice and a matched group of controls. Significant abnormalities were demonstrated, most importantly a fall in essential fatty acids, in the jaundiced group. Overall the saturation of this fraction, as assessed by double bond index, rose. The essential fatty acids are important as factors in membrane function and as precursors of eicosanoids. The abnormalities found in this study provide further evidence of the significance of EFA in patients with obstructive jaundice.

STUDIES ON THE MECHANISMS BY WHICH ERUCIC ACID AFFECTS CHOLESTEROL METABOLISM: DISTRIBUTION OF ERUCIC ACID IN ADRENAL AND PLASMA LIPIDS

1962 ◽  
Vol 40 (8) ◽  
pp. 1115-1122 ◽  
Author(s):  
K. K. Carroll
Keyword(s):  
Fatty Acids ◽  
Erucic Acid ◽  
Plasma Lipids ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Eicosenoic Acid ◽  
Lipid Classes ◽  
Gas Liquid Chromatography ◽  
Cholesterol Esters ◽  
Plasma Triglycerides

The effect of dietary erucic acid on the fatty acid composition of cholesterol ester, triglyceride and phospholipid fractions of rat adrenal, and plasma has been determined. Lipid classes were separated by chromatography on Florisil and their component fatty acids were determined by gas–liquid chromatography. Erucic acid was found in large amounts in adrenal cholesterol esters and in moderate amounts in adrenal and plasma triglycerides. Only small amounts were found in plasma cholesterol esters or the phospholipids of either adrenals or plasma. Eicosenoic acid was observed in some cases and the level of oleic acid was increased in most lipid classes of both tissues. This indicated partial stepwise oxidation of erucic acid. The increase in adrenal cholesterol caused by feeding erucic acid appears to be due primarily to accumulation of cholesterol erucate.

scholarly journals Gestational Age Dependency of Essential Fatty Acids in Cord Plasma Cholesterol Esters and Triglycerides

1994 ◽  
Vol 35 (4) ◽  
pp. 461-469 ◽  
Author(s):  
Edda B Hoving ◽  
Hristien M Van Beusekom ◽  
Henk J Nijeboer ◽  
Frits A J Muskiet
Keyword(s):  
Fatty Acids ◽  
Gestational Age ◽  
Plasma Cholesterol ◽  
Essential Fatty Acids ◽  
Cholesterol Esters ◽  
Age Dependency ◽  
Cord Plasma

STUDIES ON THE MECHANISMS BY WHICH ERUCIC ACID AFFECTS CHOLESTEROL METABOLISM: DISTRIBUTION OF ERUCIC ACID IN ADRENAL AND PLASMA LIPIDS

1962 ◽  
Vol 40 (1) ◽  
pp. 1115-1122 ◽  
Author(s):  
K. K. Carroll
Keyword(s):  
Fatty Acids ◽  
Erucic Acid ◽  
Plasma Lipids ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Eicosenoic Acid ◽  
Lipid Classes ◽  
Gas Liquid Chromatography ◽  
Cholesterol Esters ◽  
Plasma Triglycerides

The effect of dietary erucic acid on the fatty acid composition of cholesterol ester, triglyceride and phospholipid fractions of rat adrenal, and plasma has been determined. Lipid classes were separated by chromatography on Florisil and their component fatty acids were determined by gas–liquid chromatography. Erucic acid was found in large amounts in adrenal cholesterol esters and in moderate amounts in adrenal and plasma triglycerides. Only small amounts were found in plasma cholesterol esters or the phospholipids of either adrenals or plasma. Eicosenoic acid was observed in some cases and the level of oleic acid was increased in most lipid classes of both tissues. This indicated partial stepwise oxidation of erucic acid. The increase in adrenal cholesterol caused by feeding erucic acid appears to be due primarily to accumulation of cholesterol erucate.

The Effect of n-3 Fatty Acids on Lipids and Haemostasis in Patients with Type lla and Type IV Hyperlipidaemia

1989 ◽  
Vol 62 (02) ◽  
pp. 797-801 ◽  
Author(s):  
E Berg Schmidt ◽  
E Ernst ◽  
K Varming ◽  
J O Pedersen ◽  
J Dyerberg
Keyword(s):  
Fatty Acids ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Apolipoprotein A1 ◽  
Type Iv ◽  
Before And After ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

SummaryPlasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A1 decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type II a and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.

scholarly journals The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 430
Author(s):  
Claire Mayer ◽  
Léo Richard ◽  
Martine Côme ◽  
Lionel Ulmann ◽  
Hassan Nazih ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Metabolic Disorders ◽  
Disease Risk ◽  
Plasma Cholesterol ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Standard Diet ◽  
Metabolic Disturbances ◽  
Tisochrysis Lutea

Long-chain polyunsaturated fatty acids n-3 series and especially docosahexaenoic acid are known to exert preventive effects on metabolic disturbances associated with obesity and decrease cardiovascular disease risk. n-3 LC-PUFAs are mainly consumed in the form of fish oil, while other sources, such as certain microalgae, may contain a high content of these fatty acids. The aim of this study was to evaluate the effects of Tisochrysis lutea (Tiso), a microalga rich in DHA, on metabolic disorders associated with obesity. Three male Wistar rat groups were submitted for eight weeks to a standard diet or high-fat and high fructose diet (HF), supplemented or not with 12% of T. lutea (HF-Tiso). The supplementation did not affect plasma alanine aminotransferase (ALAT). Bodyweight, glycemia and insulinemia decreased in HF-Tiso rats (ANOVA, p < 0.001), while total plasma cholesterol, high-density lipoprotein-cholesterol (HDL-C) increased (ANOVA, p < 0.001) without change of low-density lipoprotein-cholesterol (LDL-C) and triacylglycerol (TAG) levels. Tiso supplementation decreased fat mass and leptinemia as well as liver TAG, cholesterol and plasma tumor necrosis factor-alpha levels (ANOVA, p < 0.001) while it did not affect interleukin 6 (IL-6), IL-4 and lipopolysaccharides levels. HF-Tiso rats showed an increase of IL-10 level in abdominal adipose tissue (ANOVA, p < 0.001). In conclusion, these results indicated that DHA-rich T. lutea might be beneficial for the prevention of obesity and improvement of lipid and glucose metabolism.

Relationship between Fatty Acids of Adipose Tissue and Plasma Cholesterol

1975 ◽  
Vol 17 (4) ◽  
pp. 204-209
Author(s):  
A. Bucalossi ◽  
F. Bellini
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Plasma Cholesterol
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