Evaluation of penicillin hypersensitivity: Value of clinical history and skin testing with penicilloyl-polylysine and penicillin G A cooperative prospective study of the penicillin study group of the American Academy of Allergy

In its statement, "Anaphylaxis," The American Academy of Pediatrics Committee on Drugs states in part: "If there is a possibility of sensitivity to . . . penicillin, skin testing for immediate hypersensitivity to the agent should be performed prior to its therapeutic administration."1 The Penicillin Study Group of the American Academy of Allergy reported in 1971 that only 17 (30.4%) of 56 patients with a history of immediate (including anaphylactic) reactions to penicillin exhibited positive skin tests to penicillin G.2

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A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group

Diabetes ◽

10.2337/diabetes.44.6.652 ◽

1995 ◽

Vol 44 (6) ◽

pp. 652-657 ◽

Cited By ~ 76

Author(s):

H. Hyoty ◽

M. Hiltunen ◽

M. Knip ◽

M. Laakkonen ◽

P. Vahasalo ◽

...

Keyword(s):

Prospective Study ◽

Study Group ◽

Childhood Diabetes ◽

A Prospective Study ◽

Coxsackie B

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Skin testing and drug challenge in the evaluation of drug hypersensitivity reactions

Allergy and Asthma Proceedings ◽

10.2500/aap.2021.42.200091 ◽

2021 ◽

Vol 42 (1) ◽

pp. 16-21 ◽

Cited By ~ 1

Author(s):

Anna R. Wolfson ◽

Aleena Banerji

Keyword(s):

Negative Impact ◽

Skin Testing ◽

Drug Hypersensitivity ◽

Clinical History ◽

Hypersensitivity Reactions ◽

Causative Drug ◽

Care Assessment ◽

Drug Hypersensitivity Reactions ◽

Drug Challenge ◽

Drug Challenges

Immediate hypersensitivity to drugs is characterized by symptoms such as hives, swelling, and wheezing. To prevent a negative impact on care, assessment by an allergist is important. Evaluation requires a clear clinical history, but it is often lacking or vague, which makes a diagnosis difficult. Allergists instead can use skin testing and drug challenge to evaluate drug hypersensitivity reactions, which help the patient and provider understand the causative drug(s) and, more importantly, enables the use of the exonerated drug(s). Although penicillin skin testing is standardized, well described, and widely used, skin testing for most other drugs requires the use of a nonirritating skin testing concentration that can have a low negative predictive value. Drug challenges are the criterion standard for confirming tolerance. The allergist must obtain an in-depth clinical history and then follow with skin testing and/or drug challenges when indicated to determine which drugs can be de-labelled and which should be avoided. In this review, we focused on the evaluation of drug hypersensitivity reactions to antibiotics, perioperative agents, biologics, and chemotherapeutics.

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Customised gold weight eyelid implantation in paralytic lagophthalmos

The Journal of Laryngology & Otology ◽

10.1017/s0022215108001886 ◽

2008 ◽

Vol 122 (10) ◽

pp. 1088-1091 ◽

Cited By ~ 7

Author(s):

N Jayashankar ◽

K P Morwani ◽

M J Shaan ◽

S R Bhatia ◽

K T Patil

Keyword(s):

Visual Acuity ◽

Prospective Study ◽

Study Design ◽

Study Group ◽

Upper Eyelid ◽

Eyelid Closure ◽

Gold Weight ◽

One Year ◽

A Prospective Study

AbstractGold eyelid implantation is widely considered the procedure of choice to reanimate the upper eyelid in paralytic lagophthalmos. Commercially supplied implants are not readily available in all places and are sometimes cumbersome to import.Objective:We aimed to devise a method whereby every surgeon performing gold eyelid implantation could have easy and quick access to the implant. Furthermore, we aimed to develop a means of creating an implant of the exact weight required for complete eyelid closure.Study design and setting:A prospective study was performed from 1997 to 2005 in a tertiary research hospital, involving 50 subjects requiring gold upper eyelid implantation and using the technique in question.Results:Only patients with a minimum follow up of one year were included in the study group. Symptoms improved in 96 per cent of subjects, who were able to dispense with eyedrops and eye ointments. Visual acuity improved in 92 per cent of patients. There were two extrusions amongst the early cases.Conclusion and significance:Customised gold eyelid implantation offers an alternative in regions where commercial implants are not easily obtained.

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Splenectomy in children with idiopathic thrombocytopenic purpura: A prospective study of 134 children from the Intercontinental Childhood ITP Study Group

Pediatric Blood & Cancer ◽

10.1002/pbc.21108 ◽

2007 ◽

Vol 49 (6) ◽

pp. 829-834 ◽

Cited By ~ 65

Author(s):

Thomas Kühne ◽

Victor Blanchette ◽

George R. Buchanan ◽

Ugo Ramenghi ◽

Hugo Donato ◽

...

Keyword(s):

Prospective Study ◽

Idiopathic Thrombocytopenic Purpura ◽

Study Group ◽

Thrombocytopenic Purpura ◽

A Prospective Study

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A clinicoradiological scoring for management of acute subdural hematoma: a prospective study

Romanian Neurosurgery ◽

10.2478/romneu-2018-0045 ◽

2018 ◽

Vol 32 (2) ◽

pp. 359-365

Author(s):

Sachidanand Gautam ◽

Anubhav Sharma ◽

S.C. Dulara

Keyword(s):

Prospective Study ◽

Subdural Hematoma ◽

Scoring System ◽

Head Injuries ◽

Postoperative Outcome ◽

Clinical History ◽

Acute Subdural Hematoma ◽

Subdural Hemorrhage ◽

Male Predominance ◽

A Prospective Study

Abstract Background: Acute subdural hematoma is the most common type of traumatic intra cranial hematoma accounting for 24% cases of severe head injuries and caries highest mortality. The aim of this study is to analyze the prognostic factors and to propose Neuro-clinical and radiological prognostic scoring system on the clinical spectrum and to evaluate the postoperative outcome and validate the same. Methods: This is a prospective Study which included 100 patients admitted in Government Medical College, Kota, Rajasthan from 01st Jan 2016 to 30 June 2017 with head injury and were diagnosed to have Traumatic Subdural Hemorrhage. A detailed clinical history, Physical examination, Computerized Tomography scan was performed in all patients and were divided into 2 groups; that is conservative or surgical interventional as per Neuro-clinical and radiological prognostic scoring system. Results: The maximum patients suffering from Subdural Hematoma were in the age group of 11-60 years with male predominance 72%. The most common mode of injury was RTA with 68 % of incidence. 36 out of 100 cases presented to hospital with GCS <8 while 44 patients showed improvement of GCS after resuscitation. Out of 100 cases, surgical approach was considered in 34 patients while remaining patients were managed conservatively. Pupillary reaction, Hypotension, CT scan findings that is, thickness of hematoma >10mm and midline shift of >5mm, delay in interval between the surgery had greatly affected on outcome of patients. Conclusions: According to the results, use of Neuro-clinical and radiological prognostic scoring system is very useful in determining early intervention and also avoids unnecessary surgical intervention.

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Allergy skin testing: Science or quackery?

PEDIATRICS ◽

10.1542/peds.59.4.495 ◽

1977 ◽

Vol 59 (4) ◽

pp. 495-498

Author(s):

Gail G. Shapiro ◽

C. Warren Bierman ◽

Clifton T. Furukawa ◽

William E. Pierson

Keyword(s):

Physical Examination ◽

American Academy ◽

Surgical Procedures ◽

Skin Testing ◽

Skin Tests ◽

Elective Surgical Procedures ◽

American Academy Of Pediatrics ◽

Telephone Calls ◽

Allergy Skin Testing

A commentary in Pediatrics in September 19751 condemned procedure-oriented fee schedules because they encouraged and rewarded the abuse of laboratory and elective surgical procedures. Allergy skin testing was included in this list. Letters to the American Academy of Pediatrics and telephone calls to the Chairman of the Section on Allergy of the Academy took issue with this inclusion. The commentary, however, was directed toward physicians and allergy laboratories who abuse skin testing rather than toward the procedure itself. It was directed to those who perform innumerable and casually selected skin tests as a substitute for an appropriate history, physical examination, and carefully selected tests based on that evaluation.

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Epistaxis as a marker for severe acute respiratory syndrome coronavirus-2 status – a prospective study

The Journal of Laryngology & Otology ◽

10.1017/s0022215120001863 ◽

2020 ◽

Vol 134 (8) ◽

pp. 717-720 ◽

Cited By ~ 1

Author(s):

MH Hussain ◽

M Mair ◽

P Rea

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Prospective Study ◽

Control Group ◽

Study Group ◽

Chain Reaction ◽

Polymerase Chain Reaction Testing ◽

The Mean ◽

Polymerase Chain ◽

The Difference ◽

A Prospective Study

AbstractObjectiveTo evaluate the prevalence of severe acute respiratory syndrome coronavirus-2 infection in patients presenting with epistaxis to a tertiary otolaryngology unit.MethodsA prospective study was conducted of 40 consecutive patients presenting with epistaxis referred to our tertiary otolaryngology unit. A group of 40 age-matched controls were also included. All patients underwent real-time reverse transcriptase polymerase chain reaction testing for severe acute respiratory syndrome coronavirus-2. Symptoms of fever, cough and anosmia were noted in the study group.ResultsThe mean age was 66.5 ± 22.4 years in the study group. There were 22 males (55 per cent) and 18 females (45 per cent). The mean age in the control group was 66.3 ± 22.4 years (p = 0.935). There were six positive cases for severe acute respiratory syndrome coronavirus-2 (15 per cent) in the epistaxis group and one case (2.5 per cent) in the control group. The difference was statistically significant (p = 0.05).ConclusionEpistaxis may represent a presenting symptom of severe acute respiratory syndrome coronavirus-2 infection. This may serve as a useful additional criterion for screening patients.

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Efficacy of psychological intervention for patients with psoriasis vulgaris: a prospective study

Journal of International Medical Research ◽

10.1177/0300060520961674 ◽

2020 ◽

Vol 48 (10) ◽

pp. 030006052096167

Author(s):

Xiaoli Li ◽

Liangliang Liu ◽

Yanfei Zhang ◽

Li Li

Keyword(s):

Quality Of Life ◽

Prospective Study ◽

Psoriasis Vulgaris ◽

Psychological Intervention ◽

Compliance Rate ◽

Psychological Status ◽

Control Group ◽

Study Group ◽

Self Rating

Objective The study aim was to examine the effect of a psychological intervention on patients with psoriasis vulgaris. Methods Participants in this prospective study were 205 patients with psoriasis vulgaris, 104 who received a psychological intervention (study group) and 101 who received routine nursing care (control group). An additional 291 healthy subjects formed a non-psoriasis group. The Symptom Checklist-90 (SCL-90), Generic Quality of Life Inventory (GQOLI), Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) were used to evaluate psychological status and quality of life. Results There were significant differences in SCL-90 and GQOLI scores between the study and non-psoriasis groups. After treatment, the study group showed significantly improved scores on the SCL-90 and GQOLI compared with the control group. Scores on the SDS (mean ± standard deviation: 31.99 ± 4.54 vs. 44.08 ± 4.52) and SAS (28.36 ± 4.52 vs. 40.14 ± 6.33) were improved in the study group. In addition, patients in the study group showed higher satisfaction rate and compliance rate than those in the control group. Conclusion Psychological intervention may be beneficial for improving quality of life and the therapeutic efficacy of drugs in patients with psoriasis.

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