Role of pluripoietins in murine bone marrow stem cell differentiation

1980 ◽  
Vol 4 (3) ◽  
pp. 287-299 ◽  
Author(s):  
Emilia Frindel ◽  
Dominique Dumenil ◽  
Françoise Sainteny
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Bone Marrow Stem Cell ◽  
Murine Bone Marrow ◽  
Marrow Stem Cell

scholarly journals Effects of melatonin on the Bisphenol-A- induced cytotoxicity and genetic toxicity in colon cancer cell lines, normal gingival cell lines, and bone marrow stem cell lines

2021 ◽  
Vol 20 ◽  
pp. 117693512110562
Author(s):  
Rouya Ebrahimi ◽  
Mohammad Shokrzadeh ◽  
Nasrin Ghassemi Barghi
Keyword(s):  
Oxidative Stress ◽  
Bone Marrow ◽  
Colon Cancer ◽  
Stem Cell ◽  
Bisphenol A ◽  
Cell Lines ◽  
Bone Marrow Stem Cell ◽  
In Vivo Models ◽  
Marrow Stem Cell

Bisphenol-A (BPA) is a synthetic chemical that has widely been used in the production of polycarbonate plastic and epoxy resins in the manufacture of consumer products. The most common path of human exposure to BPA is by oral intake that involves genotoxicity, oxidative stress, endocrine disruption, mutagenicity, and carcinogenicity in both in vitro and in vivo models. Melatonin is known as a free-radical scavenger and a powerful antioxidant agent. This study aimed to investigate the effects of melatonin on viability and genetic disorders of normal Human Gingival Fibroblasts (HGF), colon cancer (MKN45), and bone marrow stem cell (MSC) lines exposed to BPA. For this purpose, MTT and Comet assays were performed to evaluate the cytotoxicity and genotoxicity properties of BPA and the role of melatonin. The results showed that BPA exposure resulted in increased oxidative stress parameters including MDA and ROS, and decreased GSH content. The current study demonstrated the cytotoxicity and genotoxicity effects of BPA and the protective role of melatonin in preventing cytotoxicity and DNA damage are induced by BPA.

Bone marrow stem cell transplant into intra-bone cavity prevents type 2 diabetes: Role of heme oxygenase-adiponectin

2008 ◽  
Vol 30 (3) ◽  
pp. 128-135 ◽  
Author(s):  
Nader G. Abraham ◽  
Ming Li ◽  
Luca Vanella ◽  
Stephen J. Peterson ◽  
Susumu Ikehara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bone Marrow ◽  
Stem Cell ◽  
Heme Oxygenase ◽  
Stem Cell Transplant ◽  
Bone Marrow Stem Cell ◽  
Cell Transplant ◽  
Marrow Stem Cell
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