Pavlovian conditioning of drug-induced changes in body temperature

To test the previously reported theory that changes in brain amine levels caused by drugs would lead to disturbances in body temperature regulation, the levels of 5-hydroxytryptamine and noradrenaline in the whole brain of male albino rats were determined after the animals were treated with drugs and then exposed to room temperature or elevated temperatures of 37 or 40 °C. Control experiments with untreated animals were run in parallel. The drugs used were reserpine, α-methyl-m-tyrosine (MMT), 4-chloro-N-methyl-amphetamine, 3,4-dihydroxyphenyl-L-alanine (dopa), 5-hydroxy-DL-tryptophan (5-HTP), chlorpromazine, and 2,4-dinitrophenol. The results indicated that amine levels of the brain could be increased or decreased pharmacologically without a significant interference in body temperature regulation, and also that certain drugs which interfered with body temperature regulation did so without any effect on whole-brain amine levels. It was concluded that, in the rat, there were no clear-cut relationships between whole-brain 5-hydroxytryptamine or noradrenaline levels and the ability to regulate body temperature.

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Drug-induced changes in body temperature and 5-hydroxytryptamine (5-HT) turnover rate in the rat brain

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)65533-2 ◽

1975 ◽

Vol 25 ◽

pp. 91

Author(s):

Yasuo Watanabe ◽

Setsuo Tomizawa ◽

Tetsuo Oka

Keyword(s):

Body Temperature ◽

Rat Brain ◽

Turnover Rate ◽

Drug Induced ◽

Induced Changes

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QT interval correction for drug-induced changes in body temperature in dogs

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2016.02.106 ◽

2016 ◽

Vol 81 ◽

pp. 367

Author(s):

Abdel-Ilah El Amrani ◽

Francine El Amrani ◽

Stephane Loriot ◽

Pramila Singh ◽

Roy Forster

Keyword(s):

Body Temperature ◽

Qt Interval ◽

Drug Induced ◽

Induced Changes

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Drug Induced Changes in Cell Organelles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100299 ◽

1968 ◽

Vol 26 ◽

pp. 110-111

Author(s):

Sarah A. Luse

Keyword(s):

Clinical Medicine ◽

Cell Organelles ◽

Riboflavin Deficiency ◽

Drug Induced ◽

New Era ◽

Health And Disease ◽

In The Beginning ◽

Cellular Pathology ◽

Induced Changes ◽

The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

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