Microinjections of growth hormone-releasing factor into the medial preoptic area/suprachiasmatic nucleus region of the hypothalamus stimulate food intake in rats

1988 ◽  
Vol 21 (1-2) ◽  
pp. 21-28 ◽  
Author(s):  
Franco J. Vaccarino ◽  
Mars Hayward
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Suprachiasmatic Nucleus ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Growth Hormone Releasing Factor

Characterization of feeding behavior induced by central injection of GRF

1990 ◽  
Vol 259 (3) ◽  
pp. R651-R657 ◽  
Author(s):  
P. R. Dickson ◽  
F. J. Vaccarino
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Suprachiasmatic Nucleus ◽  
Paraventricular Nucleus ◽  
Wistar Rats ◽  
Preoptic Area ◽  
Behavioral Responses ◽  
Behavioral Measures ◽  
Male Wistar Rats

The behavior resulting from injection of rat hypothalamic growth hormone-releasing factor (GRF) (0, 0.01, 0.1, 1.0 pmol) into the suprachiasmatic nucleus-medial preoptic area (SCN/MPOA) or the paraventricular nucleus (PVN) of the hypothalamus was examined. After injections of GRF, feeding and other behavioral responses of male Wistar rats were observed for 90 min. In the SCN/MPOA, GRF dose dependently increased food intake, increasing mean meal length at 0.1 pmol and increasing rate of eating with no effect on meal length at 1.0 pmol. Other behavioral measures were unaffected by GRF. There was no effect after injections into the PVN. These data are taken as confirmation that the SCN/MPOA region of the hypothalamus is important for the central stimulatory effects of GRF on feeding. The possibility that the PVN is involved in the expression of feeding derived from intra-SCN/MPOA GRF injections is discussed.

GFAP Expression in Astrocytes of Suprachiasmatic Nucleus and Medial Preoptic Area are Differentially Affected by Malnutrition during Rat Brain Development

2004 ◽  
Vol 7 (4) ◽  
pp. 223-234 ◽  
Author(s):  
João Esmeraldo Frota Mendonça ◽  
Maria Cristina Ramos Vilela ◽  
Heitor Bittencourt ◽  
Raíssa Maria Lapa ◽  
Francisco Gilberto Oliveira ◽  
...  
Keyword(s):  
Brain Development ◽  
Rat Brain ◽  
Suprachiasmatic Nucleus ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Gfap Expression

Microinjection of Galanin-Like Peptide into the Medial Preoptic Area Stimulates Food Intake in Adult Male Rats

2006 ◽  
Vol 18 (10) ◽  
pp. 742-747 ◽  
Author(s):  
M. Patterson ◽  
K. G. Murphy ◽  
E. L. Thompson ◽  
K. L. Smith ◽  
K. Meeran ◽  
...  
Keyword(s):  
Food Intake ◽  
Adult Male ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Male Rats

Microinjection of Dihydrotestosterone into the Medial Preoptic Area Produces Male-Like Pattern of Growth Hormone Secretion in Ovariectomized Female Rats

2002 ◽  
Vol 75 (6) ◽  
pp. 384-391 ◽  
Author(s):  
Reiko Tokita ◽  
Yoko Kasagi ◽  
Tomoko Nakata ◽  
Kensaku Sakae ◽  
Toshihiro Imaki ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Preoptic Area ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Medial Preoptic Area ◽  
Female Rats

Centrally administered hypothalamic growth hormone-releasing factor stimulates food intake in free-feeding rats

Peptides ◽  
1988 ◽  
Vol 9 ◽  
pp. 35-38 ◽  
Author(s):  
F.J. Vaccarino ◽  
D. Feifel ◽  
J. Rivier ◽  
W. Vale ◽  
G.F. Koob
Keyword(s):  
Growth Hormone ◽  
Food Intake ◽  
Growth Hormone Releasing Factor ◽  
Free Feeding

Effects of activation and blockade of orexin A receptors in the medial preoptic area on food intake in male rats

2015 ◽  
Vol 604 ◽  
pp. 157-160 ◽  
Author(s):  
Abdolrahman Sarihi ◽  
Amir Hossein Emam ◽  
Mohammad Hosseini Panah ◽  
Alireza Komaki ◽  
Sadegh Seif ◽  
...  
Keyword(s):  
Food Intake ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Male Rats ◽  
Orexin A

Involvement of the medial preoptic area in the anorectic action of estrogens

1997 ◽  
Vol 272 (1) ◽  
pp. R311-R317 ◽  
Author(s):  
A. Dagnault ◽  
D. Richard
Keyword(s):  
Energy Balance ◽  
Food Intake ◽  
Preoptic Area ◽  
Direct Interaction ◽  
Medial Preoptic Area ◽  
Ovariectomized Rats ◽  
Co2 Production ◽  
Guide Cannula ◽  
Bed Nucleus ◽  
Production Ratio

The implication of the medial preoptic area (MPOA) as a site for estrogen in the regulation of energy balance was investigated. Food intake, O2 consumption (VO2), and CO2 production were measured in ovariectomized rats injected with estradiol (E2) in the medial preoptic nucleus (MPN). Moreover, knowing the potential for corticotropin-releasing factor (CRF) in the anorectic effects of estrogens, we identified estrogen receptors (ER) colocalized in CRF-containing cells of the MPOA and how MPN injections of CRF compared with estrogen injections with respect to VO2 and the VO2-to-CO2 production ratio (respiratory quotient RQ). These energy balance measurements after the injections of four different doses of E2 or CRF were carried out in meal-fed rats chronically implanted with a guide cannula targeted to the MPN. The identification of cells colocalizing ER and CRF was determined using a double-immunostaining procedure revealing ER and CRF immunoreactivities with two different couplers. The injection of E2 into the MPN induced a dose-dependent reduction in food intake, whereas it did not affect VO2 or RQ. Conversely, the injection of CRF into the MPN had no effect on food intake but increased VO2 and decreased RQ. The colocalization of ER and CRF immunoreactivities was found in the MPOA and adjacent regions of the bed nucleus of the stria terminalis. In conclusion, the results of this study provide evidence that the MPOA may represent a potential site for the anorectic effects of E2. Furthermore, the presence of ER and CRF in neurons of the MPOA and adjacent areas suggests a direct interaction between estrogens and the CRF system in the MPOA that is consistent with a role for CRF in the anorectic effects of estrogens. Finally, the results of this study indicate that the effects of a CRF injection into the MPOA differ from those of estrogens, suggesting that if CRF neurons are involved in the anorectic effect of estrogens they likely exert their action outside the MPOA.

Interleukin-1 beta-induced anorexia and pyrexia in rat: relationship to hypothalamic neuropeptide Y

1995 ◽  
Vol 269 (5) ◽  
pp. E852-E857 ◽  
Author(s):  
H. D. McCarthy ◽  
S. Dryden ◽  
G. Williams
Keyword(s):  
Food Intake ◽  
Neuropeptide Y ◽  
Core Temperature ◽  
Arcuate Nucleus ◽  
Preoptic Area ◽  
Interleukin 1 ◽  
Medial Preoptic Area ◽  
Interleukin 1 Beta

We investigated the effect of recombinant human interleukin-1 beta (rhIL-1 beta)-induced anorexia and pyrexia on the hypothalamic neuropeptide Y (NPY)-ergic system, which stimulates feeding and reduces thermogenesis. In meal-fed rats, food intake decreased by 83%, 90 min after IL-1 beta treatment (1.3 micrograms/100 g ip; n - 8) vs. controls. NPY concentrations were significantly higher in the medial preoptic area (MPO), paraventricular (PVN), ventromedial (VMN), and dorsomedial (DMN) nuclei but unchanged in the arcuate nucleus (ARC) in both IL-1 beta-treated and pair-fed groups. Indomethacin (0.25 mg/100 g ip) reduced IL-1 beta-induced anorexia and tended to normalize NPY concentrations. In study 2, IL-1 beta increased core temperature by 1.1 degrees C above preinjection values (P < 0.001) and significantly raised NPY concentrations in the MPO, PVN, VMN, and DMN compared with controls, 60 min postinjection. Indomethacin prevented the pyrexia and normalized hypothalamic NPY levels. As NPY concentrations were not increased in the ARC (the hypothalamic site of synthesis), we suggest that the increased NPY levels may result from blocked release, which would be in accord with the known experimental effects of NPY.

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