Proline and hepatic lipogenesis

1984 ◽  
Vol 798 (3) ◽  
pp. 368-373 ◽  
Author(s):  
M SUGDEN ◽  
D WATTS ◽  
P WEST ◽  
T NORMANPALMER
Keyword(s):  
Hepatic Lipogenesis

The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL/6N mice

2021 ◽  
Author(s):  
Jeong Hoon Pan ◽  
Hanvit Cha ◽  
Jingsi Tang ◽  
Seoyoon Lee ◽  
Suk Hee Lee ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Blood Stream ◽  
Hepatic Lipogenesis ◽  
Dietary Fructose

Fructose-induced hepatic miR-33 suppression lead to fatty liver via upregulation of SREBP1. Additionally, fructose-induced hepatic ferroptosis may cause a spill-over of miR-33 into blood stream, which could be a potential serological biomarker for fructose-induced NAFLD.

scholarly journals Aberrant Hepatic Expression of PPARγ2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis

2006 ◽  
Vol 281 (49) ◽  
pp. 37603-37615 ◽  
Author(s):  
Yuan-Li Zhang ◽  
Antonio Hernandez-Ono ◽  
Patty Siri ◽  
Stuart Weisberg ◽  
Donna Conlon ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Mouse Model ◽  
Hepatic Steatosis ◽  
Hepatic Lipogenesis ◽  
Hepatic Expression

Hormonal Control of Hepatic Lipogenesis

1979 ◽  
pp. 17-42 ◽  
Author(s):  
R. A. Harris ◽  
J. P. Mapes ◽  
R. S. Ochs ◽  
D. W. Crabb ◽  
L. Stropes
Keyword(s):  
Hormonal Control ◽  
Hepatic Lipogenesis

Fat Metabolism in Three Forms of Obesity V. Hepatic Lipogenesis in Vitro

1955 ◽  
Vol 181 (3) ◽  
pp. 501-503 ◽  
Author(s):  
Jean Mayer ◽  
Norma C. Hagman ◽  
Norman B. Marshall ◽  
Anne Jones Stoops
Keyword(s):  
Fat Metabolism ◽  
Hepatic Lipogenesis

Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity

2002 ◽  
Vol 282 (1) ◽  
pp. E46-E51 ◽  
Author(s):  
Frédérique Diraison ◽  
Eric Dusserre ◽  
Hubert Vidal ◽  
Monique Sothier ◽  
Michel Beylot
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid Synthase ◽  
Regulatory Element ◽  
Energy Restriction ◽  
Mrna Levels ◽  
Hepatic Lipogenesis ◽  
Deuterated Water ◽  
Human Obesity ◽  
Fas Mrna ◽  
Obese Subjects

To determine whether increased lipogenesis contributes to human obesity, we measured (postabsorptive state), in lean and obese subjects, lipid synthesis (deuterated water method) and the mRNA concentration (RT-competitive PCR) in subcutaneous adipose tissue of fatty acid synthase (FAS) and sterol regulatory element-binding protein (SREBP)-1c. Before energy restriction, obese subjects had an increased contribution of hepatic lipogenesis to the circulating triglyceride pool (14.5 ± 1.3 vs. 7.5 ± 1.9%, P < 0.01) without enhancement of cholesterol synthesis. This increased hepatic lipogenesis represented an excess of 2–5 g/day of triglycerides, which would represent 0.7–1.8 kg on a yearly basis. The lipogenic capacity of adipose tissue appeared, on the contrary, decreased with lower FAS mRNA levels ( P < 0.01) and a trend for decreased SREBP-1c mRNA ( P = 0.06). Energy restriction in obese patients decreased plama insulin ( P < 0.05) and leptin ( P < 0.05) and normalized hepatic lipogenesis. FAS mRNA levels were unchanged, whereas SREBP-1c increased. In conclusion, subjects with established obesity have an increased hepatic lipogenesis that could contribute to their excessive fat mass but no evidence for an increased lipogenic capacity of adipose tissue.

scholarly journals Short‐term high‐fat diet impairs regulation of hepatic lipogenesis in rats

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Kathleen Axen ◽  
Marianna A. Harper ◽  
Yu‐Fu Kuo ◽  
Kenneth Axen
Keyword(s):  
High Fat Diet ◽  
Hepatic Lipogenesis ◽  
High Fat ◽  
Short Term

scholarly journals Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

2018 ◽  
Vol 128 (12) ◽  
pp. 5335-5350 ◽  
Author(s):  
Hu Huang ◽  
Seung-Hwan Lee ◽  
Inês Sousa-Lima ◽  
Sang Soo Kim ◽  
Won Min Hwang ◽  
...  
Keyword(s):  
Rho Kinase ◽  
Hepatic Lipogenesis

scholarly journals Hepatic lipogenesis in young rats given proteins of different quality

1984 ◽  
Vol 52 (1) ◽  
pp. 131-137 ◽  
Author(s):  
G. R. Herzberg ◽  
Minda Rogerson
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Protein Quality ◽  
Fatty Acid Synthetase ◽  
Acid Synthesis ◽  
Hepatic Lipogenesis ◽  
Atp Citrate Lyase ◽  
Specific Activities ◽  
Glucose 6 Phosphate Dehydrogenase

1. The effect of feeding casein, lactalbumin, soya-bean protein, gluten or gelatin on hepatic lipogenesis and the levels of hepatic fatty acid synthetase (FAS), glucose-6-phosphate dehydrogenase (EC 1. 1. 1.49; G6PD), malic enzyme (EC 1. 1. 1.40; ME) ATP-citrate lyase (EC 4. 1. 3. 8; CL), acetyl CoA carboxylase (EC 6.4.1.2; ACCx) and glucokinase (EC 2. 7. 1. 2; GK) was examined in young growing rats.2. The total activities of ACCx, FAS, CL, GK, G6PD, GK, ME and fatty acid synthesis in vivo were positively correlated with protein quality.3. The specific activities of ACCx, FAS, CL, G6PD and fatty acid synthesis in vivo were positively correlated with protein quality.4. The specific activities of GK and ME were unrelated to protein quality.5. The results demonstrate a dissociation between ME and hepatic lipogenesis and suggest a role for the NADPH generated by ME which is not related to the needs of fatty acid synthesis.

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