Sarcomas followig radiation therapy for breast cancer: A report of three cases and a review of the literature

1995 ◽  
Vol 31 (2) ◽  
pp. 405-410 ◽  
Author(s):  
Susan C. Pendlebury ◽  
Michael Bilous ◽  
Allan O. Langlands
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Review Of The Literature

Acanthosis nigricans in patient with breast cancer and hepatocellular carcinoma: case report and review of the literature

2016 ◽  
Vol 19 (4) ◽  
pp. 196-199
Author(s):  
Erik K. Saribekyan ◽  
A. G Zubovskaya
Keyword(s):  
Breast Cancer ◽  
Hepatocellular Carcinoma ◽  
Ovarian Cancer ◽  
Bladder Cancer ◽  
Radiation Therapy ◽  
Clinical Case ◽  
Acanthosis Nigricans ◽  
Review Of The Literature ◽  
Skin Hyperpigmentation ◽  
Underlying Malignancy

Acanthosis nigricans (AN) is characterized by hyperpigmented, thickened skin plaques with a velvety texture. The histology of these lesions shows hyperkeratosis and dermal papillomatosis. According to the clinical data the key role in the development of acanthosis nigricans belongs to an excessive concentration of growth factors. Such condition is ofparticular interest because of its association with internal malignancies. Its malignant form is often associated with gastric adenocarcinoma (55-61%), though coexistence with a variety of other malignancies (ovarian cancer, endometrial carcinoma, bladder cancer, etc.) has been reported. Clinical case of patient with AN and coexisting breast cancer and hepatocellular carcinoma is presented. The severity of skin manifestations improved after chemotherapy, mastectomy and radiation therapy. However, skin hyperpigmentation relapsed after development of the hepatocellular carcinoma and the progression of the primary tumor. An underlying malignancy should be suspected in each case of AN.

scholarly journals Surgical dilemma of the management of breast cancer in a patient with neurofibromatosis: case report and a review of the literature

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Miguel Johnson ◽  
Lorna Cook ◽  
Fabio Rapisarda ◽  
Riccardo Bonomi ◽  
Dibendu Betal
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Case Report ◽  
Autosomal Dominant ◽  
Neurofibromatosis Type ◽  
Skin Lesions ◽  
Review Of The Literature ◽  
Dominant Disease ◽  
Ongoing Surveillance

Abstract Neurofibromatosis type 1 (NF-1)—also commonly known as Von Recklinghausen’s disease—is an autosomal dominant disease that represents a constellation of clinical features. There are well-established links between NF-1 and many tumors; however, the link between NF-1 and breast cancer has more recently been elucidated. While the management of breast cancer is generally well established, there are unique challenges noted in patients with NF-1. There may be delayed presentations due to difficulty in differentiating underlying neurofibroma from a sinister breast mass. Additionally, multiple skin lesions seen in NF-1 create challenges in the interpretation of mammography. Furthermore, a surgical conundrum is created, as these patients appear to have a higher risk of angiosarcoma following radiotherapy. A mastectomy may be the best option as it obviates the need for radiation therapy and ongoing surveillance. A case exemplifying these dilemmas and a review of the literature are presented.

Breast cancer associated with pregnancy: a clinical case

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 102-108
Author(s):  
Yu E Dobrokhotova ◽  
S E Arakelov ◽  
S Zh Danelyan ◽  
E I Borovkova ◽  
A E Zykov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Clinical Case ◽  
First Trimester ◽  
First Year ◽  
Total Mastectomy ◽  
First Time

Associated with pregnancy is breast cancer, which was first detected during pregnancy, during the first year after childbirth or at any time against lactation. Diagnosis of the disease in the first trimester is an indication for abortion. The detection of the disease after 20 weeks and the desire of the woman to maintain pregnancy is the basis for conducting a total mastectomy followed by polychemotherapy with doxorubicin with cyclophosphamide or with fluorouracil. Radiation therapy during pregnancy is not applied. The timing and method of delivery are determined individually and depend on the stage of the process and the period of pregnancy, when it was identified. A clinical case of a patient with edematous-infiltrative form of breast cancer of the IV stage, diagnosed for the first time in 22 weeks of pregnancy, is presented.

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