Prenatal risk factors for cot death in very preterm and small for gestational age infants

1990 ◽  
Vol 23 (1) ◽  
pp. 15-26 ◽  
Author(s):  
Henk Wierenga ◽  
Ronald Brand ◽  
Theo Geudeke ◽  
Herman P. van Geijn ◽  
Hans van der Harten ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Very Preterm ◽  
Prenatal Risk ◽  
Cot Death ◽  
Prenatal Risk Factors

scholarly journals Associations between antenatal and perinatal risk factors and cerebral palsy: a Swedish cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e038453
Author(s):  
Anna Jöud ◽  
Andréa Sehlstedt ◽  
Karin Källén ◽  
Lena Westbom ◽  
Lars Rylander
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Caesarian Section ◽  
Neonatal Care ◽  
Late Preterm ◽  
P Values ◽  
Factors Associated ◽  
Very Preterm

ObjectivesTo investigate known and suggested risk factors associated with cerebral palsy in a Swedish birth cohort, stratified by gestational age.SettingInformation on all births between 1995 and 2014 in Skåne, the southernmost region in Sweden, was extracted from the national birth register.ParticipantsThe cohort comprised a total of 215 217 children. Information on confirmed cerebral palsy and subtype was collected from the national quality register for cerebral palsy (Cerebral Palsy Follow-up Surveillance Programme).Primary and secondary outcome measuresWe calculated the prevalence of risk factors suggested to be associated with cerebral palsy and used logistic regression models to investigate the associations between potential risk factors and cerebral palsy. All analyses were stratified by gestational age; term (≥37 weeks), moderately or late preterm (32–36 weeks) and very preterm (<32 weeks).ResultsIn all, 381 (0.2 %) children were assigned a cerebral palsy diagnosis. Among term children, maternal preobesity/obesity, small for gestational age, malformations, induction, elective and emergency caesarian section, Apgar <7 at 5 min and admission to neonatal care were significantly associated with cerebral palsy (all p values<0.05). Among children born moderately or late preterm, small for gestational age, malformations, elective and emergency caesarian section and admission to neonatal care were all associated with cerebral palsy (all p values <0.05), whereas among children born very preterm no factors were significantly associated with the outcome (all p values>0.05).ConclusionOur results support and strengthen previous findings on factors associated with cerebral palsy. The complete lack of significant associations among children born very preterm probably depends on to the small number of children with cerebral palsy in this group.

Prenatal Risk Factors for Severe Retinopathy of Prematurity Among Very Preterm Infants of the Australian and New Zealand Neonatal Network

PEDIATRICS ◽  
2005 ◽  
Vol 115 (4) ◽  
pp. 990-996 ◽  
Author(s):  
B. A. Darlow ◽  
J. L. Hutchinson ◽  
D. J. Henderson-Smart ◽  
D. A. Donoghue ◽  
J. M. Simpson ◽  
...  
Keyword(s):  
Risk Factors ◽  
New Zealand ◽  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Prenatal Risk Factors for Cerebral Palsy in Very Preterm Singletons and Twins

2005 ◽  
Vol 105 (6) ◽  
pp. 1341-1347 ◽  
Author(s):  
Florence Livinec ◽  
Pierre-Yves Ancel ◽  
Stéphane Marret ◽  
Catherine Arnaud ◽  
Jeanne Fresson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Very Preterm ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Prenatal risk factors and neonatal DNA methylation in very preterm infants

2021 ◽  
Author(s):  
Marie Camerota ◽  
Stefan Graw ◽  
Todd M Everson ◽  
Elisabeth C. McGowan ◽  
Julie A Hofheimer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Preterm Infants ◽  
Latent Class ◽  
Risk Profiles ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Cpg Sites ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Background: Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates.Methods: We studied 542 infants from a multi-center study of infants born &lt;30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis (LCA) was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray.Results: We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment.Conclusion: We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.

scholarly journals Prenatal risk factors and neonatal DNA methylation in very preterm infants

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Marie Camerota ◽  
Stefan Graw ◽  
Todd M. Everson ◽  
Elisabeth C. McGowan ◽  
Julie A. Hofheimer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Preterm Infants ◽  
Latent Class ◽  
Risk Profiles ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Cpg Sites ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Abstract Background Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates. Methods We studied 542 infants from a multi-center study of infants born < 30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray. Results We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment. Conclusion We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.

RISK FACTORS FOR SMALL FOR GESTATIONAL AGE INFANTS: A STUDY BASED ON THE ARKHANGELSK COUNTY BIRTH REGISTRY

2020 ◽  
Vol 99 (1) ◽  
pp. 32-39
Author(s):  
A.A. Usynina ◽  
◽  
G.N. Chumakova ◽  
V.A. Postoev ◽  
J.O. Odland ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Birth Registry

scholarly journals Prenatal Sociodemographic Factors Predicting Maltreatment of Children up to 3 Years Old: A Prospective Cohort Study Using Administrative Data in Japan

2021 ◽  
Vol 18 (5) ◽  
pp. 2505
Author(s):  
Aya Isumi ◽  
Kunihiko Takahashi ◽  
Takeo Fujiwara
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Child Maltreatment ◽  
Survey Data ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Characteristic Curve ◽  
Risk Scores ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Identifying risk factors from pregnancy is essential for preventing child maltreatment. However, few studies have explored prenatal risk factors assessed at pregnancy registration. This study aimed to identify prenatal risk factors for child maltreatment during the first three years of life using population-level survey data from pregnancy notification forms. This prospective cohort study targeted all mothers and their infants enrolled for a 3- to 4-month-old health check between October 2013 and February 2014 in five municipalities in Aichi Prefecture, Japan, and followed them until the child turned 3 years old. Administrative records of registration with Regional Councils for Children Requiring Care (RCCRC), which is suggestive of child maltreatment cases, were linked with survey data from pregnancy notification forms registered at municipalities (n = 893). Exact logistic regression was used for analysis. A total of 11 children (1.2%) were registered with RCCRC by 3 years of age. Unmarried marital status, history of artificial abortion, and smoking during pregnancy were significantly associated with child maltreatment. Prenatal risk scores calculated as the sum of these prenatal risk factors, ranging from 0 to 7, showed high predictive power (area under receiver operating characteristic curve 0.805; 95% confidence interval (CI), 0.660–0.950) at a cut-off score of 2 (sensitivity = 72.7%, specificity = 83.2%). These findings suggest that variables from pregnancy notification forms may be predictors of the risk for child maltreatment by the age of three.

Extensive Perivillous Fibrin and Intervillous Histiocytosis in a SARS-CoV-2 Infected Placenta From an Uninfected Newborn: A Case Report Including Immunohistochemical Profiling

2021 ◽  
pp. 109352662110251
Author(s):  
James Roberts ◽  
Jeanette D Cheng ◽  
Elizabeth Moore ◽  
Carla Ransom ◽  
Minhui Ma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Immunohistochemical Staining ◽  
Placental Pathology ◽  
Fibrin Deposition ◽  
Placental Infection ◽  
Fetal Infection

Placental infection by SARS-CoV-2 with various pathologic alterations reported. Inflammatory findings, such as extensive perivillous fibrin deposition and intervillous histiocytosis, have been postulated as risk factors for fetal infection by SARS-CoV-2. We describe the placental findings in a case of a 31-year-old mother with SARS-CoV-2 infection who delivered a preterm female neonate who tested negative for SAR-CoV2 infection. Placental examination demonstrated a small for gestational age placenta with extensive intervillous histiocytosis, syncytiotrophoblast karyorrhexis, and diffuse intervillous fibrin deposition. Immunohistochemical staining demonstrated infection of the syncytiotrophoblasts by SARS-CoV-2 inversely related to the presence of intervillous histiocytes and fibrin deposition. Our case demonstrates that despite extensive placental pathology, no fetal transmission of SARS-CoV-2 occurred, as well as postulates a relationship between placental infection, inflammation, and fibrin deposition.

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