Prenatal Risk Factors for Severe Retinopathy of Prematurity Among Very Preterm Infants of the Australian and New Zealand Neonatal Network

PEDIATRICS ◽  
2005 ◽  
Vol 115 (4) ◽  
pp. 990-996 ◽  
Author(s):  
B. A. Darlow ◽  
J. L. Hutchinson ◽  
D. J. Henderson-Smart ◽  
D. A. Donoghue ◽  
J. M. Simpson ◽  
...  
Keyword(s):  
Risk Factors ◽  
New Zealand ◽  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Prenatal risk factors and neonatal DNA methylation in very preterm infants

2021 ◽  
Author(s):  
Marie Camerota ◽  
Stefan Graw ◽  
Todd M Everson ◽  
Elisabeth C. McGowan ◽  
Julie A Hofheimer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Preterm Infants ◽  
Latent Class ◽  
Risk Profiles ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Cpg Sites ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Background: Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates.Methods: We studied 542 infants from a multi-center study of infants born <30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis (LCA) was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray.Results: We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment.Conclusion: We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.

scholarly journals Prenatal risk factors and neonatal DNA methylation in very preterm infants

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Marie Camerota ◽  
Stefan Graw ◽  
Todd M. Everson ◽  
Elisabeth C. McGowan ◽  
Julie A. Hofheimer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Preterm Infants ◽  
Latent Class ◽  
Risk Profiles ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Cpg Sites ◽  
Prenatal Risk ◽  
Prenatal Risk Factors

Abstract Background Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates. Methods We studied 542 infants from a multi-center study of infants born < 30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray. Results We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physical (26%) and psychological (13%) risk factors. Neonates born to women in higher risk subgroups had differential DNAm at 2 CpG sites. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment. Conclusion We observed associations between prenatal risk factors and DNAm in very preterm infants using both person-centered and cumulative risk approaches. Epigenetics offers a potential biological indicator of prenatal risk exposure.

scholarly journals Incidence and risk factors of retinopathy of prematurity in an Italian cohort of preterm infants

2021 ◽  
Vol 47 (1) ◽  
Author(s):  
Carlo Dani ◽  
Caterina Coviello ◽  
Fiorenza Panin ◽  
Saverio Frosini ◽  
Simonetta Costa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Neonatal Intensive Care ◽  
Neonatal Intensive Care Units ◽  
Maternal Milk ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Stage 1 ◽  
Mother’S Own Milk

AbstractObjectiveNon-negligible differences in retinopathy of prematurity (ROP) and its risk factors between different neonatal intensive care units (NICUs) are reported. Our aim was to assess the incidence and risk factors for ROP development in a large cohort of very preterm infants who were assisted in two Italian NICUs.MethodsPreterm infants with gestational age between 23+ 0and 29+ 6weeks were stratified into subgroups of infants who developed ROP and those who did not; their clinical characteristics were compared with univariate and multivariable logistic regression analyses.ResultsWe studied a total of 178 infants of whom 67 (38%) developed ROP (stage 1:n = 12; stage 2:n = 41; stage 3:n = 14). Regression analysis demonstrated that maternal milk (OR 0.979, 95% Cl 0.961–0.998) decreased the risk of developing ROP, while intraventricular hemorrhage (IVH) (OR 2.055, 95% Cl 1.120–3.772) increased it. Moreover, maternal milk was found to decrease (OR 0.981, 95% Cl 0.964–0.997) the risk of ROP at discharge, while RBC transfusion increased it (OR 1.522, 95% Cl 1.208–1.916).ConclusionsIn our cohort the occurrence of ROP was similar to that previously reported. Strategies for promoting the use of mother’s own milk, preventing IVH, and standardizing the approach to RBC transfusions could contribute to decreasing the risk of ROP in very preterm infants.

scholarly journals Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants

2017 ◽  
Vol 106 (3) ◽  
pp. 821-830 ◽  
Author(s):  
Jean-Christophe Rozé ◽  
Pierre-Yves Ancel ◽  
Patricia Lepage ◽  
Laetitia Martin-Marchand ◽  
Ziad Al Nabhani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gut Microbiota ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Microbiota Composition ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Nutritional Strategies ◽  
Gut Microbiota Composition

Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006–2015: a population-based analysis

2017 ◽  
Vol 103 (4) ◽  
pp. F337-F342 ◽  
Author(s):  
Roland Gerull ◽  
Viviane Brauer ◽  
Dirk Bassler ◽  
Bernard Laubscher ◽  
Riccardo E Pfister ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Retinopathy Of Prematurity ◽  
Cohort Analysis ◽  
Survival Rates ◽  
Patient Characteristics ◽  
Developed Countries ◽  
Population Based ◽  
Screening Criteria ◽  
Very Preterm Infants ◽  
Very Preterm

BackgroundRetinopathy of prematurity (ROP) is a severe complication of preterm birth and can lead to severe visual impairment or even blindness if untreated. The incidence of ROP requiring treatment is increasing in some developed countries in conjunction with higher survival rates at the lower end of gestational age (GA).Material and methodsThe incidence of ROP and severe ROP (sROP) requiring treatment in Switzerland was analysed using the SwissNeoNet registry. We conducted a retrospective cohort analysis of very preterm infants with a GA below 32 weeks who were born between 2006 and 2015 in Switzerland. Patient characteristics were stratified according to GA.Results9.3% and 1.8% of very preterm infants in Switzerland developed ROP of any stage and sROP, respectively. The incidence of ROP treatment was 1.2%. Patients with 24 and 25 weeks GA had the highest proportion of ROP treatment at 14.5% and 7.3%, respectively, whereas the proportion of treated infants at or above a GA of 29 weeks was 0.06%. Similarly, the risk of sROP declined strongly with increasing GA. During the observation period of 10 years, the incidence of ROP treatment ranged between 0.8% and 2.0%. Incidences of sROP or ROP treatment did not increase over time.ConclusionThe incidence of ROP treatment in Switzerland is low and was stable over the analysed period. The low incidence of sROP in patients with a GA of 29 weeks or more leaves room for a redefinition of ROP screening criteria.

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