scholarly journals 4521688 Three-dimensional and tomographic imaging device for x-ray and gamma-ray emitting objects

1986 ◽  
Vol 10 (1) ◽  
pp. xi-xii
2010 ◽  
Vol 25 (2) ◽  
pp. 157-160 ◽  
Author(s):  
P. Bruyndonckx ◽  
A. Sasov ◽  
B. Pauwels

We have demonstrated that structures down to 150 nm can be visualized in X-ray projection images using nanofocus X-ray sources. Due to their unlimited depth of focus, they do not possess a limit on the specimen size. This is essential for three-dimensional tomographic imaging of samples with a diameter larger than a few microns. Further simulation studies have shown that optimization of the detector response curve and switching from a reflective X-ray target to a transmission target should allow us to reach sub-100-nm resolutions.


1980 ◽  
Vol 19 (17) ◽  
pp. 2952 ◽  
Author(s):  
Lo Yin ◽  
Jacob I. Trombka ◽  
Stephen M. Seltzer

2021 ◽  
Vol 92 (3) ◽  
pp. 033508
Author(s):  
P. L. Volegov ◽  
S. H. Batha ◽  
D. N. Fittinghoff ◽  
C. R. Danly ◽  
V. Geppert-Kleinrath ◽  
...  

2019 ◽  
Vol 882 (1) ◽  
pp. 22 ◽  
Author(s):  
Dennis Alp ◽  
Josefin Larsson ◽  
Keiichi Maeda ◽  
Claes Fransson ◽  
Annop Wongwathanarat ◽  
...  

Author(s):  
David Scott ◽  
Fred Duewer ◽  
Shashi Kamath ◽  
Alan Lyon ◽  
David Trapp ◽  
...  

Abstract X-ray microscopy has the potential to solve many failure analysis problems associated with advanced package technologies because of its ability to non-destructively inspect advanced multi-layer package designs. In addition, x-ray imaging has the potential to perform fault isolation in 3D using well-established tomographic reconstruction methods. The ability to perform high-resolution, artifact free tomographic reconstructions will be critical to the Advanced Packaging Failure Analysis community. This article discusses the requirements for a high-resolution, three-dimensional tomographic imaging microscope and shows how these requirements pose a problem for conventional projection based x-ray microscopes, specifically the requirement to place the sample in near contact with the x-ray source. The article then discusses the results from the Micro-XCT, an x-ray tomographic imaging microscope designed by Xradia, Inc., whose unique design allows for the required 180 degrees of sample rotation while simultaneously maintaining resolutions as high as 1 micrometer.


Author(s):  
James A. Lake

The understanding of ribosome structure has advanced considerably in the last several years. Biochemists have characterized the constituent proteins and rRNA's of ribosomes. Complete sequences have been determined for some ribosomal proteins and specific antibodies have been prepared against all E. coli small subunit proteins. In addition, a number of naturally occuring systems of three dimensional ribosome crystals which are suitable for structural studies have been observed in eukaryotes. Although the crystals are, in general, too small for X-ray diffraction, their size is ideal for electron microscopy.


Author(s):  
S. Cusack ◽  
J.-C. Jésior

Three-dimensional reconstruction techniques using electron microscopy have been principally developed for application to 2-D arrays (i.e. monolayers) of biological molecules and symmetrical single particles (e.g. helical viruses). However many biological molecules that crystallise form multilayered microcrystals which are unsuitable for study by either the standard methods of 3-D reconstruction or, because of their size, by X-ray crystallography. The grid sectioning technique enables a number of different projections of such microcrystals to be obtained in well defined directions (e.g. parallel to crystal axes) and poses the problem of how best these projections can be used to reconstruct the packing and shape of the molecules forming the microcrystal.Given sufficient projections there may be enough information to do a crystallographic reconstruction in Fourier space. We however have considered the situation where only a limited number of projections are available, as for example in the case of catalase platelets where three orthogonal and two diagonal projections have been obtained (Fig. 1).


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