Radiosurgical treatment planning of brain metastases based on a fast, three-dimensional MR imaging technique

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

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EMCAT: An automatic image-processing system for electron-microscopic tomography

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100169821 ◽

1994 ◽

Vol 52 ◽

pp. 418-419

Author(s):

Weiping Liu ◽

John W. Sedat ◽

David A. Agard

Keyword(s):

Image Processing ◽

Structural Information ◽

Imaging Technique ◽

Three Dimensional ◽

Processing System ◽

Electron Microscopic ◽

Data Set ◽

Ordered Structures ◽

Automatic Image Processing ◽

Em Tomography

Any real world object is three-dimensional. The principle of tomography, which reconstructs the 3-D structure of an object from its 2-D projections of different view angles has found application in many disciplines. Electron Microscopic (EM) tomography on non-ordered structures (e.g., subcellular structures in biology and non-crystalline structures in material science) has been exercised sporadically in the last twenty years or so. As vital as is the 3-D structural information and with no existing alternative 3-D imaging technique to compete in its high resolution range, the technique to date remains the kingdom of a brave few. Its tedious tasks have been preventing it from being a routine tool. One keyword in promoting its popularity is automation: The data collection has been automated in our lab, which can routinely yield a data set of over 100 projections in the matter of a few hours. Now the image processing part is also automated. Such automations finish the job easier, faster and better.

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Electrical Capacitance Volume Tomography (ECVT) for industrial and medical applications-An Overview

JOURNAL OF ADVANCES IN PHYSICS ◽

10.24297/jap.v11i1.577 ◽

2015 ◽

Vol 11 (1) ◽

pp. 2897-2908

Author(s):

Mohammed S.Aljohani

Keyword(s):

Imaging Technique ◽

Three Dimensional ◽

Biological Processes ◽

Electrical Capacitance ◽

Image Reconstruction Techniques ◽

Phase Dynamics ◽

Non Invasive ◽

Electrical Capacitance Volume Tomography ◽

And Performance ◽

Optimization And Performance

Tomography is a non-invasive, non-intrusive imaging technique allowing the visualization of phase dynamics in industrial and biological processes. This article reviews progress in Electrical Capacitance Volume Tomography (ECVT). ECVT is a direct 3D visualizing technique, unlike three-dimensional imaging, which is based on stacking 2D images to obtain an interpolated 3D image. ECVT has recently matured for real time, non-invasive 3-D monitoring of processes involving materials with strong contrast in dielectric permittivity. In this article, ECVT sensor design, optimization and performance of various sensors seen in literature are summarized. Qualitative Analysis of ECVT image reconstruction techniques has also been presented.

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A simple treatment planning strategy for patients with multiple metastases treated with Gamma Knife surgery

Journal of Neurosurgery ◽

10.3171/sup.2006.105.7.2 ◽

2006 ◽

Vol 105 (Supplement) ◽

pp. 2-4 ◽

Cited By ~ 5

Author(s):

James G. Douglas ◽

Robert Goodkin

Keyword(s):

Mr Imaging ◽

Treatment Planning ◽

Gamma Knife ◽

Gamma Knife Surgery ◽

Planning Method ◽

Cns Metastases ◽

Cell Lung Carcinoma ◽

Dose Volume Histograms ◽

Number Of Patients ◽

The Brain

ObjectIn a substantial number of patients treated at the authors' facility for brain metastases, additional lesions are identified at the time of Gamma Knife surgery (GKS). These lesions are often widely dispersed and may number over 10, which is the maximal number of matrices that can be currently placed for treatment with Leksell Gamma-Plan 4C. The authors describe a simple planning method for GKS in patients with multiple, widely dispersed central nervous system (CNS) metastases.MethodsTwo patients presented with three to five identified recurrent metastases from non–small cell lung carcinoma and breast carcinoma after having received whole-brain radiotherapy. At the time of treatment with GKS in each patient, spoiled-gradient Gd-enhanced magnetic resonance (MR) imaging revealed substantially more metastases than originally thought, which were widely scattered throughout all regions of the brain. The authors simplified the treatment planning approach by dividing the entire CNS contents into six contiguous, nonoverlapping matrices, which allowed for the planning, calculation, and treatment of all lesions.Two patients were successfully treated with GKS for more than 10 CNS metastases by using this simple planning method. Differing peripheral doses to varied-size lesions were delivered by prescribing to different isodose curves within any given matrix when required. Dose–volume histograms showed brain doses as follows: 10% of the total brain volume received 5 to 6.4 Gy; 25% received 3.8 to 4.8 Gy; 50% received 2.7 to 3.1 Gy; and 75% received 2.2 to 2.5 Gy.Conclusions The delineation of more metastases than appreciated on the diagnostic MR imaging is a common occurrence at the time of GKS at the authors' institution. The treatment of multiple (>10), widely dispersed CNS metastases can be simplified by the placement of multiple, contiguous, non-overlapping matrices, which can be employed to treat lesions in all areas of the brain when separate matrices cannot be utilized.

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