The role of vitamin D and related compounds in the treatment of bone disease in the elderly

Bone ◽  
1994 ◽  
Vol 15 (6) ◽  
pp. 727-728 ◽  
Author(s):  
J.A. Kanis ◽  
C. Cooper ◽  
R. Francis ◽  
N. Hamdy ◽  
P. Selby ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Disease ◽  
The Elderly ◽  
Related Compounds

scholarly journals Control of uremic bone disease: Role of vitamin D analogs

2002 ◽  
Vol 61 ◽  
pp. S143-S148 ◽  
Author(s):  
Eduardo Slatopolsky ◽  
Adriana Dusso ◽  
Alex J. Brown
Keyword(s):  
Vitamin D ◽  
Bone Disease ◽  
Vitamin D Analogs

Metabolic Bone Disease in the CAPD Patient

1983 ◽  
Vol 3 (1_suppl) ◽  
pp. 24-26 ◽  
Author(s):  
Francisco Llach
Keyword(s):  
Vitamin D ◽  
Renal Osteodystrophy ◽  
Bone Disease ◽  
Metabolic Bone Disease ◽  
Osteitis Fibrosa ◽  
Prospective Evaluation ◽  
Metabolic Bone ◽  
Capd Patient

It seems that CAPD may improve some patients with osteomalacia but may be similar to hemodialysis in regard to osteitis fibrosa. However, long-term prospective evaluation of the incidence of bone disease in CAPD patients is necessary before we can determine how CAPD may alter the incidence and expression of renal osteodystrophy. We need more information before we can conclude that CAPD may improve pure osteomalacia. Finally, the data available are insufficient to clarify the role of vitamin D analogues in these patients.

Non HRT Options for the Treatment of Osteoporosis

1998 ◽  
Vol 4 (3) ◽  
pp. 96-101
Author(s):  
Michael Davies
Keyword(s):  
Vitamin D ◽  
Vertebral Fracture ◽  
Bone Fractures ◽  
The Elderly ◽  
Long Bone ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Supplemental Calcium ◽  
Treatable Condition

Osteoporosis is now a treatable condition with an abundance of evidence for the efficacy of certain therapeutic strategies in preventing recurrent fractures. Most of these treatments act by improving bone mineral density through inhibition or reduction of bone resorption. For those women who are unable to take HRT; bisphosphonates, calcium, vitamin D, calcitriol or calcitonin may confer certain benefits. The bisphosphonate alendronate reduces both vertebral and long bone fractures, an effect seen soon after starting treatment. The changes in BMD and fracture reduction are less with the use of etidronate but it is certainly beneficial in reducing recurrent vertebral fracture. In the elderly calcium and vitamin D in combination can reduce non-vertebral and hip fracture and supplemental calcium of 1 g/day has been predicted to reduce bone loss and thus hip fractures by 22%. Evidence that calcitriol or calcitonin reduce fracture incidence is not good but calcitonin has been shown to have analgesic properties in those with acute vertebral fracture. The role of calcitriol is less certain and should be reserved for women with vertebral fractures in whom HRT or bisphosphonates cannot be used.

Substantiation for vitamin D supplementation in the elderly

2020 ◽  
pp. 13-20
Author(s):  
Natalya Mamylina
Keyword(s):  
Vitamin D ◽  
Peripheral Blood ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Neutrophil Granulocytes ◽  
Blood Neutrophil ◽  
Peripheral Blood Neutrophil ◽  
Cytokine Balance ◽  
Sf 36

Role of vitamin D in the formation of pathogenic changes related to factors of innate immunity and cytokine status has been studied in 105 non-working women aged 61.0±1.25 years. Prior to the study, the quality of life has been determined using the SF-36 questionnaire, as well as decrease in total vitamin D content, violation of functional and metabolic status of peripheral blood neutrophil granulocytes, imbalance in subpopulation of lymphocytes, and production of Th1/Th2 cytokines have been revealed. Presence of direct correlation between the qualitative composition and oxygen-dependent metabolism of peripheral blood neutrophil granulocytes, vitamin D content, and cytokine balance has been proved. Vitamin D supplementation in a daily dose of 1000 reduced the severity of immune disorders in the patients, which confirms the need for vitamin D supplementation in the elderly with a vitamin D deficiency confirmed by laboratory tests.

scholarly journals The role of vitamin D in improving physical performance in the elderly

2013 ◽  
Vol 28 (10) ◽  
pp. 2194-2201 ◽  
Author(s):  
Violet Lagari ◽  
Orlando Gómez-Marín ◽  
Silvina Levis
Keyword(s):  
Vitamin D ◽  
Physical Performance ◽  
The Elderly

scholarly journals Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects

2010 ◽  
Vol 7 (1) ◽  
Author(s):  
Cedric Annweiler ◽  
Manuel Montero-Odasso ◽  
Anne M Schott ◽  
Gilles Berrut ◽  
Bruno Fantino ◽  
...  
Keyword(s):  
Vitamin D ◽  
Fall Prevention ◽  
The Elderly

Paget’s Disease of Bone and Calcium Homeostasis: Focus on Bisphosphonate Treatment

2011 ◽  
Vol 119 (09) ◽  
pp. 519-524 ◽  
Author(s):  
S. Polyzos ◽  
A. Anastasilakis ◽  
P. Makras ◽  
E. Terpos
Keyword(s):  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Bone Disease ◽  
Bone Mineralization ◽  
Paget’S Disease ◽  
The Elderly ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone

AbstractPaget’s disease of bone (PDB) is the second most common metabolic bone disease. Bisphosphonates (BPs) are currently the drugs of choice for PDB. PDB and osteomalacia are both common in the elderly. The concept of relative vitamin D deficiency in patients with PDB was suggested long ago, but it has not yet elucidated. Both diseases predispose to fractures, but their combined action to fragility has not been studied yet. The older BPs, mainly etidronate, further inhibit bone mineralization. Mineralization defects have also been described in patients with PDB treated with pamidronate. Moreover, hypocalcemia and secondary hyperparathyroidism after treatment with BPs have been described in PDB. Hypocalcemia seems to be more severe after treatment with the more potent, intravenous zoledronic acid, which is currently the treatment of choice for PDB. The counteracting hyperparathyroidism pathophysiologically intends to increase renal reabsorption of calcium and 1.25-dihydroxy vitamin D production and to stimulate osteoclasts in order to prevent long-term hypocalcemia. However, the effect of PTH on osteoclasts is, at least partly, restricted in patients taking BPs. Secondary hyperparathyroidism is a potentially detrimental condition, especially in patients already suffering from another bone disease. Serum calcium and vitamin D deficiency should be restored before BP treatment and calcium and vitamin D administration should be possibly continued for longer after achieving normocalcemia, which may shorten the duration of secondary hyperparathyroidism.Mineralization defects and hypocalcemia with secondary hyperparathyroidism have been described in patients with Paget’s disease of bone treated with bisphosphonates. Secondary hyperparathyroidism may be a potentially detrimental condition for patients with Paget’s disease of bone.

scholarly journals Potential Roles of Vitamins in the Management of COVID-19: A Comprehensive Review

2021 ◽  
Author(s):  
Homa Rezaei ◽  
Sajad Khiali ◽  
Haleh Rezaee ◽  
Hossein Bannazadeh Baghi ◽  
Matin Pourghasem ◽  
...  
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Viral Infections ◽  
The Elderly ◽  
Underrepresented Minorities ◽  
Health Crisis ◽  
Comprehensive Review ◽  
Public Health Crisis ◽  
Severity Of The Disease

The coronavirus disease 2019 (COVID-19) outbreak has caused a public health crisis worldwide. However, data regarding the protective factors of the disease is limited. Consequently, preventive health measures that can decrease the risk of infection, progression, and severity are dreadfully required. It is well-documented that people with immunodeficiency, such as the elderly, people who already have comorbidities (e.g., diabetes mellitus, hypertension, respiratory and cardiovascular disorders), and underrepresented minorities, are placed in a group with a higher risk of getting infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A diet rich in vitamins, minerals, and antioxidants plays an essential role in strengthening the immune system and fighting against invading pathogens. The present comprehensive review has discussed published literature regarding the potential role of vitamins in strengthening the immune system and managing viral infections, particularly SARS-CoV-2 infection. Although there are controversial data regarding the plasma level of vitamin D and the severity of the disease, according to the limited evidence, vitamin D may lower the mortality rate. Moreover, vitamin C could reduce the development of inflammatory response; however, the results of ongoing clinical trials are required to confirm these primary findings.

CHANGES IN THE IMMUNE AND ANTIOXIDANT STATUS AND THE ROLE OF VITAMIN IN THEIR CORRECTION IN OLDER EDUCATORS

2020 ◽  
pp. 695-702
Author(s):  
О. А. Гизингер ◽  
В. И. Долгова ◽  
Н. В. Мамылина
Keyword(s):  
Vitamin D ◽  
Elderly Women ◽  
Free Radical Oxidation ◽  
Total Content ◽  
The Elderly ◽  
Middle Level ◽  
Secondary Products ◽  
Radical Oxidation ◽  
Humoral Immune

В исследование были включены 50 женщин в возрасте 60,0±1,5 года, преподающих в течение 30±5,5 лет в среднем звене общеобразовательной школы (5-9-е классы) - основная группа, и 50 неработающих женщин 61,5±1,3 года - контрольная группа. Цель исследования - изучение роли витамина D в формировании иммунопатогенетических изменений со стороны клеточных и гуморальных иммунных факторов, процессов свободнорадикального окисления у работающих педагогов и неработающих женщин пожилого возраста и возможности коррекции выявленных нарушений дотацией витамина D . До начала исследования выявлено снижение суммарного содержания витамина D , нарушение функционально-метаболического статуса иммуноцитов, дисбаланс субпопуляционного состава лимфоцитов, продукции Тh 1/ Тh 2 цитокинов, повышение первичных и вторичных продуктов перекисного окисления липидного экстракта плазмы крови, снижение активности СОД и каталазы в основной и контрольной группах. Доказано наличие прямых корреляций содержания витамина D , баланса цитокинов, компонентов системы ПОЛ и антиоксидантной защиты. Дотация витамина D снизила тяжесть иммунных и оксидативных нарушений у обследуемых. Полученные результаты подтверждают необходимость мониторинга содержания витамина D для снижения риска развития иммунопатогенетических нарушений у лиц пожилого возраста. The study included 50 women aged 60±1,5 years, teaching for 30±5,5 years at the middle level of a secondary school (grades 5-9) - main group, and 50 non-working women 61,5±1,3 years. The purpose of the study was to study the role of vitamin D in the formation of immunopathogenetic changes from cellular and humoral immune factors, free radical oxidation processes in working teachers and unemployed elderly women and the possibility of correcting the revealed violations with vitamin D subsidy. Before the start of the study, a decrease in the total content of vitamin D was revealed , violation of the functional and metabolic status of immunocytes, an imbalance in the production of Th 1/ Th 2 cytokines, an increase in primary and secondary products peroxidation of the lipid extract of blood plasma, a decrease in the activity of superoxide dismutase and catalase to the main and control groups. The presence of direct correlations between the content of vitamin D , the balance of cytokines, the components of the lipid peroxidation system and antioxidant defense is proved. A vitamin D subsidy reduced the severity of immune and oxidative disorders in subjects. The obtained results confirm the need for monitoring the vitamin D content in order to reduce the risk of developing immunopathogenetic disorders in the elderly.

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