CHANGES IN THE IMMUNE AND ANTIOXIDANT STATUS AND THE ROLE OF VITAMIN IN THEIR CORRECTION IN OLDER EDUCATORS

2020 ◽  
pp. 695-702
Author(s):  
О. А. Гизингер ◽  
В. И. Долгова ◽  
Н. В. Мамылина
Keyword(s):  
Vitamin D ◽  
Elderly Women ◽  
Free Radical Oxidation ◽  
Total Content ◽  
The Elderly ◽  
Middle Level ◽  
Secondary Products ◽  
Radical Oxidation ◽  
Humoral Immune

В исследование были включены 50 женщин в возрасте 60,0±1,5 года, преподающих в течение 30±5,5 лет в среднем звене общеобразовательной школы (5-9-е классы) - основная группа, и 50 неработающих женщин 61,5±1,3 года - контрольная группа. Цель исследования - изучение роли витамина D в формировании иммунопатогенетических изменений со стороны клеточных и гуморальных иммунных факторов, процессов свободнорадикального окисления у работающих педагогов и неработающих женщин пожилого возраста и возможности коррекции выявленных нарушений дотацией витамина D . До начала исследования выявлено снижение суммарного содержания витамина D , нарушение функционально-метаболического статуса иммуноцитов, дисбаланс субпопуляционного состава лимфоцитов, продукции Тh 1/ Тh 2 цитокинов, повышение первичных и вторичных продуктов перекисного окисления липидного экстракта плазмы крови, снижение активности СОД и каталазы в основной и контрольной группах. Доказано наличие прямых корреляций содержания витамина D , баланса цитокинов, компонентов системы ПОЛ и антиоксидантной защиты. Дотация витамина D снизила тяжесть иммунных и оксидативных нарушений у обследуемых. Полученные результаты подтверждают необходимость мониторинга содержания витамина D для снижения риска развития иммунопатогенетических нарушений у лиц пожилого возраста. The study included 50 women aged 60±1,5 years, teaching for 30±5,5 years at the middle level of a secondary school (grades 5-9) - main group, and 50 non-working women 61,5±1,3 years. The purpose of the study was to study the role of vitamin D in the formation of immunopathogenetic changes from cellular and humoral immune factors, free radical oxidation processes in working teachers and unemployed elderly women and the possibility of correcting the revealed violations with vitamin D subsidy. Before the start of the study, a decrease in the total content of vitamin D was revealed , violation of the functional and metabolic status of immunocytes, an imbalance in the production of Th 1/ Th 2 cytokines, an increase in primary and secondary products peroxidation of the lipid extract of blood plasma, a decrease in the activity of superoxide dismutase and catalase to the main and control groups. The presence of direct correlations between the content of vitamin D , the balance of cytokines, the components of the lipid peroxidation system and antioxidant defense is proved. A vitamin D subsidy reduced the severity of immune and oxidative disorders in subjects. The obtained results confirm the need for monitoring the vitamin D content in order to reduce the risk of developing immunopathogenetic disorders in the elderly.

The role of vitamin D and related compounds in the treatment of bone disease in the elderly

Bone ◽  
1994 ◽  
Vol 15 (6) ◽  
pp. 727-728 ◽  
Author(s):  
J.A. Kanis ◽  
C. Cooper ◽  
R. Francis ◽  
N. Hamdy ◽  
P. Selby ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Disease ◽  
The Elderly ◽  
Related Compounds

Clinical and pathogenetic role of state of prooxidant-antioxidant regulation in patients with purulent meningitis in the dynamics of disease

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
D. A. Zadyraka ◽  
E. V. Riabokon
Keyword(s):  
Free Radical ◽  
Conventional Treatment ◽  
Free Radical Oxidation ◽  
Oxidative Modification ◽  
Blood Proteins ◽  
Radical Oxidation ◽  
Pathogenetic Role ◽  
Purulent Meningitis ◽  
Laboratory Changes

The paper shows, that patients with purulent meningitis on the background of severe clinical and laboratory changes had a disturbance of prooxidant-antioxidant regulation with a shift towards activation of free radical oxidation. In the dynamics of the disease, after 7-10 days of conventional treatment, against the background of a reduction of cephalic and meningeal syndromes intensity, a normalization of liquor and hemogram indices, in most patients there was a further decrease in catalase activity and an increase of nitrites, of parameters of spontaneous and induced oxidative modification of blood proteins that remained when the patients were discharged, compared with healthy people.

Non HRT Options for the Treatment of Osteoporosis

1998 ◽  
Vol 4 (3) ◽  
pp. 96-101
Author(s):  
Michael Davies
Keyword(s):  
Vitamin D ◽  
Vertebral Fracture ◽  
Bone Fractures ◽  
The Elderly ◽  
Long Bone ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Supplemental Calcium ◽  
Treatable Condition

Osteoporosis is now a treatable condition with an abundance of evidence for the efficacy of certain therapeutic strategies in preventing recurrent fractures. Most of these treatments act by improving bone mineral density through inhibition or reduction of bone resorption. For those women who are unable to take HRT; bisphosphonates, calcium, vitamin D, calcitriol or calcitonin may confer certain benefits. The bisphosphonate alendronate reduces both vertebral and long bone fractures, an effect seen soon after starting treatment. The changes in BMD and fracture reduction are less with the use of etidronate but it is certainly beneficial in reducing recurrent vertebral fracture. In the elderly calcium and vitamin D in combination can reduce non-vertebral and hip fracture and supplemental calcium of 1 g/day has been predicted to reduce bone loss and thus hip fractures by 22%. Evidence that calcitriol or calcitonin reduce fracture incidence is not good but calcitonin has been shown to have analgesic properties in those with acute vertebral fracture. The role of calcitriol is less certain and should be reserved for women with vertebral fractures in whom HRT or bisphosphonates cannot be used.

scholarly journals Chemiluminescence Studies of Lipoperoxidation Processes in Arterial Hypertension and Stress

2019 ◽  
Vol 4 (1) ◽  
pp. 133-137
Author(s):  
Anastasiya S. Brichagina ◽  
Mariya I. Dolgikh ◽  
Larisa R. Kolesnikova ◽  
Larisa V. Natyaganova
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Free Radical Oxidation ◽  
The State ◽  
Male Rats ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Biochemical Methods ◽  
Peroxidation Processes

Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.

scholarly journals Occurrence of Malassezia Spp. on Healthy Human Skin

2019 ◽  
Vol 63 (4) ◽  
pp. 54-59
Author(s):  
Z. Malinovská ◽  
E. Čonková ◽  
P. Váczi ◽  
M. Harčárová ◽  
E. Böhmová
Keyword(s):  
Normal Skin ◽  
Seborrheic Dermatitis ◽  
The Elderly ◽  
Host Immune System ◽  
Healthy Human ◽  
Humoral Immune ◽  
Clinically Normal ◽  
Malassezia Spp ◽  
Animal Skin

Abstract The genus Malassezia currently includes seventeen species that have been isolated from healthy and diseased human and other animal skin. Malassezia are implicated in a range of cutaneous diseases in humans: pityriasis versicolor, atopic or seborrheic dermatitis, dandruff, folliculitis and psoriasis. The outbreak of the disease depends on the interaction between the host immune system and Malassezia species. Malassezia stimulates both the cellular and humoral immune response in humans. Although Malassezia species have been associated with various dermatological diseases in people, the detailed pathological role of Malassezia remains obscured. Malassezia yeasts require lipids for their growth and therefore to a greater extent they colonize the sites with more sebaceous glands. The ecosystem on skin is complex and its balance depends on several factors. The aim of this study was to determine the presence of Malassezia yeasts in clinically normal skin of 42 healthy, randomly selected individuals of different ages. In the group of people examined, up to 30 persons (71.4 %) represented by children, adults and the elderly were positive to Malassezia yeasts. It has been shown that the back is an area with a higher incidence (66.7 %) of observed yeast compared to the head (40.5 %).

Substantiation for vitamin D supplementation in the elderly

2020 ◽  
pp. 13-20
Author(s):  
Natalya Mamylina
Keyword(s):  
Vitamin D ◽  
Peripheral Blood ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Neutrophil Granulocytes ◽  
Blood Neutrophil ◽  
Peripheral Blood Neutrophil ◽  
Cytokine Balance ◽  
Sf 36

Role of vitamin D in the formation of pathogenic changes related to factors of innate immunity and cytokine status has been studied in 105 non-working women aged 61.0±1.25 years. Prior to the study, the quality of life has been determined using the SF-36 questionnaire, as well as decrease in total vitamin D content, violation of functional and metabolic status of peripheral blood neutrophil granulocytes, imbalance in subpopulation of lymphocytes, and production of Th1/Th2 cytokines have been revealed. Presence of direct correlation between the qualitative composition and oxygen-dependent metabolism of peripheral blood neutrophil granulocytes, vitamin D content, and cytokine balance has been proved. Vitamin D supplementation in a daily dose of 1000 reduced the severity of immune disorders in the patients, which confirms the need for vitamin D supplementation in the elderly with a vitamin D deficiency confirmed by laboratory tests.

scholarly journals Social capital and under-utilization of medication for financial reasons among elderly women: evidence from two Brazilian health surveys

2013 ◽  
Vol 18 (12) ◽  
pp. 3721-3730 ◽  
Author(s):  
Tatiana Chama Borges Luz ◽  
Antônio Ignácio de Loyola Filho ◽  
Maria Fernanda Lima-Costa
Keyword(s):  
Physical Environment ◽  
Elderly Women ◽  
Later Life ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Belo Horizonte ◽  
Perception Of Health ◽  
System Characteristics

This cross-sectional study assesses the prevalence and examines the role of social and demographic factors, health conditions, health system characteristics and contextual factors of under-utilization of medication for financial reasons among elderly women. Participants in the Greater Metropolitan Belo Horizonte Health Survey (GMBH) and the eleventh phase of the Bambuí Cohort Study of the Elderly were assessed. Among elderly women in the GMBH, the prevalence of under-utilization was 11.4%, and in Bambuí, the rate was 5.4%. Self-perception of health (OR, 3.46; 95%CI, 1.32_9.10); daily life limitations (OR, 2.75; 95% CI, 1.31-5.78) and perception of help (OR, 2.36; 95% CI, 1.07-5.25) had independent associations with under-utilization among GMBH residents. A poor perception of both cohesion in the neighborhood (OR, 2.38; 95% CI, 1.02-5.56) and the physical environment (OR, 2.58; 95% CI, 1.10-6.03) significantly increased the likelihood of under-utilization among Bambuí residents. These results provide important clues to identifying possible risk factors for under-utilization, highlighting the need to develop strategies targeting the amplification of the involvement between elderly women and their community to reduce the extent of under-utilization in later life.

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