Antioxidant and Anti-Inflammatory Actions of Passion Fruit Peel Extract in Modifying Osteoarthritis, Hypertension, and Asthma

2013 ◽  
pp. 633-639 ◽  
Author(s):  
F.M. Cordova ◽  
S. Zibadi ◽  
R.R. Watson
Keyword(s):  
Passion Fruit ◽  
Fruit Peel ◽  
Anti Inflammatory ◽  
Peel Extract

Passion fruit peel extract attenuates bleomycin-induced pulmonary fibrosis in mice

2014 ◽  
Vol 92 (8) ◽  
pp. 631-639 ◽  
Author(s):  
Shanmuga Reddy Chilakapati ◽  
Mamatha Serasanambati ◽  
Pavan Kumar Manikonda ◽  
Damodar Reddy Chilakapati ◽  
Ronald Ross Watson
Keyword(s):  
Pulmonary Fibrosis ◽  
Antioxidant Activities ◽  
Intratracheal Instillation ◽  
Inflammatory Cells ◽  
Lavage Fluid ◽  
Passion Fruit ◽  
Fruit Peel ◽  
Tissue Sections ◽  
Anti Inflammatory ◽  
Peel Extract

Idiopathic pulmonary fibrosis is a progressive fatal lung disease characterized by excessive collagen deposition, with no effective treatments. We investigated the efficacy of natural products with high anti-inflammatory activity, such as passion fruit peel extract (PFPE), in a mouse model of bleomycin-induced pulmonary fibrosis (PF). C57BL/6J mice were subjected to a single intratracheal instillation of bleomycin to induce PF. Daily PFPE treatment significantly reduced loss of body mass and mortality rate in mice compared with those treated with bleomycin. While bleomycin-induced PF resulted in elevated total numbers of inflammatory cells, macrophages, lymphocytes, and neutrophils in bronchoalveolar lavage fluid on both days 7 and 21, PFPE administration significantly attenuated these phenomena compared with bleomycin group. On day 7, the decreased superoxide dismutase and myeloperoxidase activities observed in the bleomycin group were significantly restored with PFPE treatment. On day 21, enhanced hydroxyproline deposition in the bleomycin group was also suppressed by PFPE administration. PFPE treatment significantly attenuated extensive inflammatory cell infiltration and accumulation of collagen in lung tissue sections of bleomycin-induced mice on days 7 and 21, respectively. Our results indicate that administration of PFPE decreased bleomycin-induced PF because of anti-inflammatory and antioxidant activities.

scholarly journals Hepatoprotective Activity and Nephroprotective Activity of Peel Extract from Three Varieties of the Passion Fruit (Passiflora Sp.) in the Albino Rat

2019 ◽  
Vol 7 (4) ◽  
pp. 536-542 ◽  
Author(s):  
Nerdy Nerdy ◽  
Kiking Ritarwan
Keyword(s):  
Body Weight ◽  
Hepatoprotective Activity ◽  
Positive Control ◽  
Passion Fruit ◽  
Fruit Peel ◽  
Albino Rat ◽  
Nephroprotective Activity ◽  
Purple Passion Fruit ◽  
Peel Extract ◽  
Yellow Passion Fruit

BACKGROUND: The Passion Fruit (Passiflora sp.) that grows in the Indonesian region generally has three varieties, namely purple passion fruit (Passiflora edulis Sims.), red passion fruit (Passiflora ligularis Juss.), and yellow passion fruit (Passiflora verrucifera Lindl.). The passion fruit peel is an economic waste that has not been utilised optimally, but has many efficacious phytochemical contents. AIM: The objectives of this research are to examine scientifically hepatoprotective activity (with paracetamol-induced hepatotoxic) and nephroprotective activity (with gentamicin-induced nephrotoxic) from three varieties of the passion fruit (purple passion fruit peel extract, red passion fruit peel extract and yellow passion fruit peel extract) in the albino rat (Rattus norvegicus). METHODS: Three varieties of passion fruit peels were extracted by maceration method. The experimental animals used were the albino rat (Rattus norvegicus). Hepatoprotective activity was done by the liver biochemical (alanine transaminase and aspartate transaminase) analysis with paracetamol (hepatotoxic compound) induced after 10 days of treatment with extract. Nephroprotective activity was done by the kidney biochemical (urea and creatinine) analysis with gentamicin (nephrotoxic compound) induced after 10 days of treatment with extract. RESULTS: The hepatoprotective activity for positive control was similar to the 250 mg of purple passion fruit peel extract per kg of body weight, 250 mg of red passion fruit peel extract per kg of body weight, and 500 mg of yellow passion fruit peel extract per kg of body weight. The nephroprotective activity for positive control (50 mg of silymarin per kg of body weight) was similar to the 250 mg of purple passion fruit peel extract per kg of body weight, 500 mg of red passion fruit peel extract per kg of body weight, and 500 mg of yellow passion fruit peel extract per kg of body weight. CONCLUSIONS: The extracts were shown hepatoprotective activity and nephroprotective activity with a dose-dependent activity. The hepatoprotective activity and nephroprotective activity of purple passion fruit peel extract were the best compared to red passion fruit peel extract and yellow passion fruit peel extract.

Oral Administration of the Purple Passion Fruit Peel Extract Reduces Asthma Symptoms in Humans

2008 ◽  
Vol 121 (2) ◽  
pp. S221-S221
Author(s):  
R FARID ◽  
S ZIBADI ◽  
H RAFATPANAH ◽  
F JABBARI ◽  
R GHASEMI ◽  
...  
Keyword(s):  
Oral Administration ◽  
Passion Fruit ◽  
Fruit Peel ◽  
Asthma Symptoms ◽  
Purple Passion Fruit ◽  
Peel Extract

Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma

2008 ◽  
Vol 28 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Ronald Ross Watson ◽  
Sherma Zibadi ◽  
Houshang Rafatpanah ◽  
Farahzad Jabbari ◽  
Ramin Ghasemi ◽  
...  
Keyword(s):  
Oral Administration ◽  
Passion Fruit ◽  
Shortness Of Breath ◽  
Fruit Peel ◽  
Purple Passion Fruit ◽  
Peel Extract

Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis

2010 ◽  
Vol 30 (9) ◽  
pp. 601-606 ◽  
Author(s):  
Reza Farid ◽  
Zahra Rezaieyazdi ◽  
Zahra Mirfeizi ◽  
Mohamad Reza Hatef ◽  
Mahyar Mirheidari ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Physical Function ◽  
Oral Intake ◽  
Adult Patients ◽  
Passion Fruit ◽  
Fruit Peel ◽  
Purple Passion Fruit ◽  
Peel Extract

Efficacy of Purple Passion Fruit Peel Extract in Lowering Cardiovascular Risk Factors in Type 2 Diabetic Subjects

2013 ◽  
Vol 18 (3) ◽  
pp. 183-190 ◽  
Author(s):  
I. Naga Raju ◽  
K. Kodandarami Reddy ◽  
C. Krishna Kumari ◽  
E. Bhaskar Reddy ◽  
S. Dattatreya Rao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Passion Fruit ◽  
Fruit Peel ◽  
Purple Passion Fruit ◽  
Type 2 Diabetic ◽  
Peel Extract

The clinical efficacy of purple passion fruit peel extract (a flavonoid-rich dietary supplement) in reducing cardiovascular risk factors in adult type 2 diabetic subjects was investigated in a randomized, double-blind, placebo-controlled trial. Forty-one subjects were randomly assigned to receive a daily dose of purple passion fruit (220 mg) or a matched placebo for 16 weeks. Body mass index, blood pressure, fasting and postprandial blood glucose, glycated hemoglobin, and lipid profile were determined at baseline and at monthly intervals. A significant reduction in systolic blood pressure and fasting blood glucose was observed following administration of purple passion fruit ( P < .05). Purple passion fruit was well tolerated, and no adverse events were reported. These data suggest that purple passion fruit supplementation for 16 weeks in type 2 diabetics results in a significant reduction in systolic blood pressure and fasting blood glucose, indicating that purple passion fruit is safe and well tolerated by diabetics.

scholarly journals Antihypertensive effects of purple passion fruit peel extract in rats and humans

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Sherma Zibadi ◽  
Pooya Moslemzadeh Tehrani ◽  
Satoru Moriguchi ◽  
Yinrong Lu ◽  
Lai Yeap Foo ◽  
...  
Keyword(s):  
Passion Fruit ◽  
Fruit Peel ◽  
Purple Passion Fruit ◽  
Peel Extract

scholarly journals Antiaging Activity of Gel Preparation Containing Three Varieties of Passion Fruit Peel Ethanolic Extract

2020 ◽  
Vol 8 (A) ◽  
pp. 170-174
Author(s):  
Nazliniwaty Nazliniwaty ◽  
Fathur Rahman Harun ◽  
Effendy De Lux Putra ◽  
Nerdy Nerdy
Keyword(s):  
Agricultural Waste ◽  
Economic Value ◽  
Ethanolic Extract ◽  
Natural Antioxidants ◽  
Premature Aging ◽  
Passion Fruit ◽  
Fruit Peel ◽  
Gel Preparation ◽  
Peel Extract ◽  
Yellow Passion Fruit

BACKGROUND: Antiaging cosmetics are cosmetics that can prevent or correct the signs of premature aging. Passion fruit (Passiflora sp.) peel is an agricultural waste contains polyphenol compounds and flavonoids which are a source of natural antioxidants to prevent premature aging. The passion fruit peel extract formulated into gel preparations which can increase the economic value of the passion fruit peel waste. OBJECTIVE: The objective of the study was to test the antiaging activity of gel preparations containing ethanolic extracts of purple, red, and yellow passion fruit on experimental animal skins with several parameters (wrinkle, melanin, pore, moisture, and elasticity). METHODS: Gel was made by adding passion fruit peel extract with several concentrations (0.05%, 0.10%, 0.15%, 0.20%, and 0.25%) in gel base. The blank used is a gel base without extracts. Measurement of wrinkle, black pigment (melanin), pore size, moisture content, and elasticity was performed using a skin analyzer. The use of gel is done 2 times a day for 28 days. RESULTS: Gel with purple, red, and yellow passion fruit peel extract can be formulated into gel preparations. The higher concentration of passion fruit peel extract shows a higher antiaging activity. Gel preparations with purple, red, and yellow passion fruit peel extract, respectively, show the recovery of wrinkle 16.16%, 8.73%, and 6.49%; recovery of melanin 20.11%, 10.75%, and 8.06%; recovery of pore 18.78%, 10.15%, and 7.69%; recovery of moisture 32.74%, 17.70%, and 13.04%; and recovery of elasticity 30.08%, 16.13%, and 12.30%. CONCLUSIONS: The highest antiaging activity was given by gel preparations containing purple passion fruit peel extract and the lowest antiaging activity was given by gel preparations with yellow passion fruit peel extracts.

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