Modulation of Structure and Function of the Plasma Membrane in the Cell Cycle of Neuroblastoma Cells

‘Cellular structure and function’ covers the roles, structures, and functions of the main four types of macromolecules of the human body, namely proteins, lipids, carbohydrates, and nucleic acids. For these macromolecules, the roles and types of each class are discussed (for proteins this includes their roles as structural proteins and enzymes and their kinetics; for lipids, the roles and types of lipid found in the body are considered; for carbohydrates, their roles including structural and metabolic are discussed; and the structure of nucleic acids is described). Then follows a description of the organization of the cell, including the plasma membrane and its components, and the intracellular organelles. Cell growth, division, and apoptosis are covered, as are the formation of gametes, and finally the principles of how cellular functions can be modulated by pharmacological agents through receptors and signalling pathways are discussed.

Download Full-text

Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function

British Journal of Pharmacology ◽

10.1111/bph.13943 ◽

2017 ◽

Vol 175 (21) ◽

pp. 4009-4025 ◽

Cited By ~ 12

Author(s):

Aditya J Desai ◽

Laurence J Miller

Keyword(s):

Metabolic Disease ◽

Plasma Membrane ◽

G Protein ◽

Structure And Function ◽

G Protein Coupled Receptor ◽

Receptor Structure ◽

Disease Impact ◽

And Function ◽

G Protein Coupled

Download Full-text

ENaC structure and function in the wake of a resolved structure of a family member

AJP Renal Physiology ◽

10.1152/ajprenal.00259.2011 ◽

2011 ◽

Vol 301 (4) ◽

pp. F684-F696 ◽

Cited By ~ 89

Author(s):

Ossama B. Kashlan ◽

Thomas R. Kleyman

Keyword(s):

Plasma Membrane ◽

Ion Channel ◽

Functional Data ◽

Ion Selectivity ◽

External Environment ◽

Structure And Function ◽

Close Proximity ◽

Channel Assembly ◽

And Function ◽

Insight Into

Our understanding of epithelial Na+ channel (ENaC) structure and function has been profoundly impacted by the resolved structure of the homologous acid-sensing ion channel 1 (ASIC1). The structure of the extracellular and pore regions provide insight into channel assembly, processing, and the ability of these channels to sense the external environment. The absence of intracellular structures precludes insight into important interactions with intracellular factors that regulate trafficking and function. The primary sequences of ASIC1 and ENaC subunits are well conserved within the regions that are within or in close proximity to the plasma membrane, but poorly conserved in peripheral domains that may functionally differentiate family members. This review examines functional data, including ion selectivity, gating, and amiloride block, in light of the resolved ASIC1 structure.

Download Full-text