Use of Total Body Photography and Serial Digital Dermoscopy in Dermatology

2016 ◽  
pp. 387-393
Author(s):  
B.W. Petersen ◽  
H.W. Higgins
Keyword(s):  
Total Body ◽  
Digital Dermoscopy

scholarly journals Total Body Photography and Sequential Digital Dermoscopy in Pregnant Women

2019 ◽  
pp. 126-131
Author(s):  
Gabriela M. Martins-Costa ◽  
Renato Bakos
Keyword(s):  
Differential Diagnosis ◽  
Cohort Study ◽  
Pregnant Women ◽  
Skin Type ◽  
Type Ii ◽  
Third Trimester ◽  
Melanocytic Nevi ◽  
Vascular Structures ◽  
Total Body ◽  
Digital Dermoscopy

Background: Melanocytic nevi can vary in size and number in pregnant women, and the differential diagnosis with melanoma may be challenging. Objectives: To describe changes in total body photography of pregnant women and dermoscopy aspects of their nevi. Methods: A prospective cohort study with 703 melanocytic nevi from 18 women was performed, comparing them in the first and third trimester of pregnancy. Images were analyzed between the 2 periods for changes in dermoscopic aspects. Results: Total body photography images indicated that 44% of patients had new lesions. Regarding the observed changes, there were symmetric or regular changes of the network (23% of cases), occurrence of new globules/dots (12.4%), new vascular structures (3.2%), new streaks (1.7%), and new structureless area (1.0%). Moreover, 55.0% of the nevi increased in size. Enlarging of the nevi was observed mostly on the abdomen (87.1%; P < 0.001) and showed more network changes (27.1%; P = 0.014) and formation of new globules and dots (16.0%; P < 0.001). Patients with a risk of developing melanoma presented more frequently enlarged nevi (45%; P = 0.019). The association between streak formation and skin type was significant (P = 0.012) and was more frequent in skin type II (2.7%), when compared with skin types III (1.3%) and IV (0%).

Metastatic melanoma patients: Prospective follow-up of pigmented lesions under vemurafenib by digital dermoscopy.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 9093-9093
Author(s):  
Marie Perier-Muzet ◽  
Stephane Dalle ◽  
Gerard Duru ◽  
Luc Thomas ◽  
Sebastien Debarbieux ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Second Primary ◽  
External Diameter ◽  
Inform Consent ◽  
Cutaneous Side Effects ◽  
Pigmented Lesions ◽  
Total Body ◽  
The Impact ◽  
Digital Dermoscopy

9093 Background: Vemurafenib is the first approved by the FDA BRAF V600 inhibitor for the treatment of metastatic melanoma. Many cutaneous side-effects such as squamous cell carcinoma, xerosis, photosensitivity are observed. We first reported the occurrence of second primary melanomas (SPM) under BRAF inhibition. These SPM were shown to be wild-type for BRAF. The exact occurrence of these changes is still unknown. We wanted then to explore prospectively the impact of vemurafenib on cutaneous pigmented lesions using sequential digital dermoscopy. Methods: We registered prospectively following inform consent the pigmented lesions of patients under vemurafenib. We examined the total body surface and captured from 9 to 134 pigmented lesions on 24 patients. Each single lesion was followed monthly from vemurafenib initiation to vemurafenib disruption due to disease progression. Dermoscopic modifications of the melanocytic lesions including external diameter, dermoscopical pattern, pigmentation, network thickness, dots distribution and keratosis appearance were analyzed. Results: The median duration of dermoscopic follow up was 6,9 months ( range from 2 to 16 months), 1098 pigmented lesions were included. At least one modification occurred in 56% of the lesions. Most frequent modifications were the occurrence of dark globules (56%), change in the pigmentation coloration (47%), variations in network thickness (32%), increase of the external size (20,1%), onset of black areas (14%), onset of keratosis (4,4%). Up to 5,3% of lesions spontaneously disappeared; 21 excisions were performed due to significant dermoscopic changes and revealed 10 early melanomas in 5/24 patients (20,8%). The 11 remaining lesions were benign. Conclusions: More than fifty percent of the patients under vemurafenib will experiment significant modifications on their pigmented lesions. In our experience 10/21 removed lesions were early melanomas that could not be otherwise diagnosed using naked-eyes examinations only. Digital dermoscopy is one of the tool that can be use to discriminate earlier the modifications. Such careful monitoring will improved the safety when evaluating BRAF inhibitors in adjuvant setting.

scholarly journals Total Body Photography and Sequential Digital Dermoscopy Imaging for Melanoma Surveillance in Patients Starting Natalizumab for Multiple Sclerosis

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Tyler Nussinow ◽  
Amanda Robinson ◽  
Biljana Beretich ◽  
Kathryn Stevens ◽  
Elizabeth Seiverling
Keyword(s):  
Multiple Sclerosis ◽  
Total Body ◽  
Melanoma Surveillance ◽  
Digital Dermoscopy

scholarly journals Evaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: protocol for a randomised controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e032969 ◽  
Author(s):  
Clare Amy Primiero ◽  
Aideen M McInerney-Leo ◽  
Brigid Betz-Stablein ◽  
David C Whiteman ◽  
Louisa Gordon ◽  
...  
Keyword(s):  
High Risk ◽  
Controlled Trial ◽  
Clinical Care ◽  
Melanoma Risk ◽  
Surveillance Programme ◽  
High Risk Melanoma ◽  
Risk Melanoma ◽  
Total Body ◽  
Randomised Controlled ◽  
Digital Dermoscopy

IntroductionMelanoma is Australia’s fourth most common cancer. Early detection is fundamental in maximising health outcomes and minimising treatment costs. To date, population-based screening programmes have not been justified in health economic studies. However, a skin surveillance approach targeting high-risk individuals could improve the cost-benefit ratio.Methods and analysisThis paper describes a 2-year longitudinal randomised controlled trial (RCT) to compare routine clinical care (control) with an intensive skin surveillance programme (intervention) consisting of novel three-dimensional (3D) total-body photography (TBP), sequential digital dermoscopy and melanoma-risk stratification, in a high-risk melanoma cohort. Primary outcomes will evaluate clinical, economic and consumer impact of the intervention. Clinical outcomes will evaluate differences in the rate of lesion excisions/biopsies per person, benign to malignant ratio for excisions and thickness of melanomas diagnosed. A health economic analysis using government data repositories will capture healthcare utilisation and costs relating to skin surveillance. Consumer questionnaires will examine intervention acceptability, the psychological impact, and attitudes towards melanoma risk and sun protective behaviour. Secondary outcomes include the development of a holistic risk algorithm incorporating clinical, phenotypic and genetic factors to facilitate the identification of those most likely to benefit from this surveillance approach. Furthermore, the feasibility of integrating the intervention with teledermatology to enhance specialist care in remote locations will be evaluated. This will be the first RCT to compare a targeted surveillance programme utilising new 3D TBP technology against current routine clinical care for individuals at high risk of melanoma.Ethics and disseminationThis study has received Human Research Ethics Committee (HREC) approval from both Metro South Health HREC (HREC/17/QPAH/816) and The University of Queensland HREC (2018000074).Trial registration numberANZCTR12618000267257; Pre-results.

Digital Dermoscopy Photographs Outperform Handheld Dermoscopy in Melanoma Diagnosis

2016 ◽  
Vol 20 (6) ◽  
pp. 602-605 ◽  
Author(s):  
Danielle Mintsoulis ◽  
Jennifer Beecker
Keyword(s):  
High Risk ◽  
Medical Records ◽  
Ottawa Hospital ◽  
Melanoma Diagnosis ◽  
Pigmented Lesion ◽  
Clinical Advantage ◽  
The Difference ◽  
Total Body ◽  
Digital Dermoscopy

Background: Pigmented lesion clinics (PLCs) that use technology such as digital dermoscopy and total-body photography are thought to confer a clinical advantage for patients at high risk of developing melanoma over general dermatology clinics (GDCs) with regular dermoscopy. Objective: To examine the difference between depths of melanomas diagnosed in a PLC and a GDC. Methods: Medical records from 257 patients at the PLC at The Ottawa Hospital and 441 patients from a GDC were reviewed. Results: Invasive melanoma was less frequent than in situ melanoma at the PLC (7.14% vs 38.27%; P = .02). The average Breslow depth for melanomas at the PLC was also smaller compared with the GDC (0.0371 vs 0.3450 mm; P = .02). Conclusions: The use of digital dermoscopy and total-body photography together in a PLC appears to be an effective way to monitor patients at high risk of melanoma.

18466 Skin cancer screening using total body photography and digital dermoscopy: A pilot study among firefighters

2020 ◽  
Vol 83 (6) ◽  
pp. AB212
Author(s):  
Rachel Fayne ◽  
Mahtab Forouzandeh ◽  
Valeria De Bedout ◽  
Mina Zarei ◽  
Joshua D. Fox ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Pilot Study ◽  
Skin Cancer ◽  
Skin Cancer Screening ◽  
Total Body ◽  
Digital Dermoscopy

Fine Structural Changes in the Microvasculature of the Mouse Pinna: Aging and Radiation Injury

1974 ◽  
Vol 32 ◽  
pp. 54-55
Author(s):  
S. Phyllis Steamer ◽  
Rosemarie L. Devine
Keyword(s):  
Structural Changes ◽  
Radiation Treatment ◽  
Arterial Stenosis ◽  
Ultrastructural Changes ◽  
Vascular Effects ◽  
Microvascular Changes ◽  
Surrounding Connective Tissue ◽  
Fission Neutrons ◽  
Total Body

The importance of radiation damage to the skin and its vasculature was recognized by the early radiologists. In more recent studies, vascular effects were shown to involve the endothelium as well as the surrounding connective tissue. Microvascular changes in the mouse pinna were studied in vivo and recorded photographically over a period of 12-18 months. Radiation treatment at 110 days of age was total body exposure to either 240 rad fission neutrons or 855 rad 60Co gamma rays. After in vivo observations in control and irradiated mice, animals were sacrificed for examination of changes in vascular fine structure. Vessels were selected from regions of specific interest that had been identified on photomicrographs. Prominent ultrastructural changes can be attributed to aging as well as to radiation treatment. Of principal concern were determinations of ultrastructural changes associated with venous dilatations, segmental arterial stenosis and tortuosities of both veins and arteries, effects that had been identified on the basis of light microscopic observations. Tortuosities and irregularly dilated vein segments were related to both aging and radiation changes but arterial stenosis was observed only in irradiated animals.

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