iSERS microscopy: point-of-care diagnosis and tissue imaging

2022 ◽  
pp. 327-372
Author(s):  
Yuying Zhang ◽  
Vi. Tran ◽  
Mujo Adanalic ◽  
Sebastian Schlücker
Keyword(s):  
Point Of Care ◽  
Tissue Imaging

scholarly journals Recent Progress on Near-Infrared Photoacoustic Imaging: Imaging Modality and Organic Semiconducting Agents

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1693 ◽  
Author(s):  
Doyoung Jung ◽  
Suhyeon Park ◽  
Changho Lee ◽  
Hyungwoo Kim
Keyword(s):  
Recent Progress ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Imaging Modality ◽  
Point Of Care ◽  
Tissue Imaging ◽  
Nir Imaging ◽  
Precise Diagnosis ◽  
Deep Tissue Imaging ◽  
Review Reports

Over the past few decades, the photoacoustic (PA) effect has been widely investigated, opening up diverse applications, such as photoacoustic spectroscopy, estimation of chemical energies, or point-of-care detection. Notably, photoacoustic imaging (PAI) has also been developed and has recently received considerable attention in bio-related or clinical imaging fields, as it now facilitates an imaging platform in the near-infrared (NIR) region by taking advantage of the significant advancement of exogenous imaging agents. The NIR PAI platform now paves the way for high-resolution, deep-tissue imaging, which is imperative for contemporary theragnosis, a combination of precise diagnosis and well-timed therapy. This review reports the recent progress on NIR PAI modality, as well as semiconducting contrast agents, and outlines the trend in current NIR imaging and provides further direction for the prospective development of PAI systems.

Assessing the utility of ultrasound in the role 2 hospital setting

2019 ◽  
pp. jramc-2019-001208 ◽  
Author(s):  
Edward Sellon ◽  
S Durdle ◽  
D Bailey
Keyword(s):  
Point Of Care ◽  
Hospital Setting ◽  
Management Plan ◽  
Routine Care ◽  
Tissue Imaging ◽  
Clinical Indication ◽  
Presumptive Diagnosis ◽  
Prospective Data ◽  
Clinical Confidence ◽  
And Training

IntroductionThe usefulness of departmental diagnostic ultrasound in the role 2 setting has not been previously evaluated. This is because role 2 hospital manning does not traditionally include a diagnostic radiologist. This study aims to evaluate the usefulness of this added capability in the deployed role 2 hospital setting.MethodsProspective data were collected using a questionnaire alongside each scan request during the Op TRENTON 3 operational period. This included details of clinical indication and presumptive diagnosis. Scans were acquired and reported as part of routine care. The postscan clinical diagnosis and effect on management plan were determined by the treating clinician and recorded on the questionnaire. Point-of-care and focused assessment with sonography in trauma scans were excluded, as were ultrasound-guided interventional procedures.Results41 diagnostic departmental scans were included over the six-month period. 68% (28/41) of the scans increased clinical confidence in the management plan, while 29% (12/41) led to an alteration in the management plan. Only one examination (3%) was deemed to have had no clinical impact. Overall, the musculoskeletal scans had the greatest impact on patient management.ConclusionsConstraints of manoeuvrability at role 2 currently preclude the availability of body CT and shift the demand for diagnostic soft tissue imaging to ultrasound. This capability is only possible with the deployment of suitably trained individuals. This study highlights the utility of this capability at role 2. Musculoskeletal ultrasound skills were of particular value, and training should be encouraged among physiotherapists and radiographers in lieu of, where necessary, a suitably trained deployable radiologist.

scholarly journals Modern Trends in Imaging VIII: Lensfree Computational Microscopy Tools for Cell and Tissue Imaging at the Point-of-Care and in Low-Resource Settings

2012 ◽  
Vol 35 (4) ◽  
pp. 229-247 ◽  
Author(s):  
Serhan O. Isikman ◽  
Alon Greenbaum ◽  
Myungjun Lee ◽  
Waheb Bishara ◽  
Onur Mudanyali ◽  
...  
Keyword(s):  
Point Of Care ◽  
Microscopic Analysis ◽  
Cost Effective ◽  
Tissue Imaging ◽  
Large Field ◽  
Optical Components ◽  
Tissue Samples ◽  
Pap Tests ◽  
Point Of Care Diagnostics ◽  
Blood Smears

The recent revolution in digital technologies and information processing methods present important opportunities to transform the way optical imaging is performed, particularly toward improving the throughput of microscopes while at the same time reducing their relative cost and complexity. Lensfree computational microscopy is rapidly emerging toward this end, and by discarding lenses and other bulky optical components of conventional imaging systems, and relying on digital computation instead, it can achieve both reflection and transmission mode microscopy over a large field-of-view within compact, cost-effective and mechanically robust architectures. Such high throughput and miniaturized imaging devices can provide a complementary toolset for telemedicine applications and point-of-care diagnostics by facilitating complex and critical tasks such as cytometry and microscopic analysis of e.g., blood smears, Pap tests and tissue samples. In this article, the basics of these lensfree microscopy modalities will be reviewed, and their clinically relevant applications will be discussed.

“Aspirin - resistance”? A few critical considerations on definition, terminology, diagnosis, clinical value, natural course of atherosclerotic disease, and therapeutic consequences

VASA ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 429-438 ◽  
Author(s):  
Berent ◽  
Sinzinger
Keyword(s):  
Platelet Function ◽  
Point Of Care ◽  
Aspirin Resistance ◽  
Point Of View ◽  
Evidence Based ◽  
Platelet Function Tests ◽  
Clinical Value ◽  
Vascular Events ◽  
Therapeutic Consequences ◽  
Function Tests

Based upon various platelet function tests and the fact that patients experience vascular events despite taking acetylsalicylic acid (ASA or aspirin), it has been suggested that patients may become resistant to the action of this pharmacological compound. However, the term “aspirin resistance” was created almost two decades ago but is still not defined. Platelet function tests are not standardized, providing conflicting information and cut-off values are arbitrarily set. Intertest comparison reveals low agreement. Even point of care tests have been introduced before appropriate validation. Inflammation may activate platelets, co-medication(s) may interfere significantly with aspirin action on platelets. Platelet function and Cox-inhibition are only some of the effects of aspirin on haemostatic regulation. One single test is not reliable to identify an altered response. Therefore, it may be more appropriate to speak about “treatment failure” to aspirin therapy than using the term “aspirin resistance”. There is no evidence based justification from either the laboratory or the clinical point of view for platelet function testing in patients taking aspirin as well as from an economic standpoint. Until evidence based data from controlled studies will be available the term “aspirin resistance” should not be further used. A more robust monitoring of factors resulting in cardiovascular events such as inflammation is recommended.

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