Multiscale processes in the M-I-T system

2022 ◽  
pp. 1-63
Keyword(s):  
T System

Three-Dimensional Visualization of the T-System of Frog Muscle Using High Voltage Electron Microscopy and a Lanthanum Stain

1977 ◽  
Vol 35 ◽  
pp. 570-571 ◽  
Author(s):  
Lee D. Peachey ◽  
Clara Franzini-Armstrong
Keyword(s):  
Electron Microscopy ◽  
High Voltage ◽  
Three Dimensional ◽  
Biological Tissues ◽  
High Voltage Electron Microscopy ◽  
Transverse Tubular System ◽  
Peroxidase Reaction ◽  
Voltage Electron ◽  
High Voltage Electron ◽  
T System

The effective study of biological tissues in thick slices of embedded material by high voltage electron microscopy (HVEM) requires highly selective staining of those structures to be visualized so that they are not hidden or obscured by other structures in the image. A tilt pair of micrographs with subsequent stereoscopic viewing can be an important aid in three-dimensional visualization of these images, once an appropriate stain has been found. The peroxidase reaction has been used for this purpose in visualizing the T-system (transverse tubular system) of frog skeletal muscle by HVEM (1). We have found infiltration with lanthanum hydroxide to be particularly useful for three-dimensional visualization of certain aspects of the structure of the T- system in skeletal muscles of the frog. Specifically, lanthanum more completely fills the lumen of the tubules and is denser than the peroxidase reaction product.

The Network Parameters Of The T-System In Frog Muscle Measured With The High Voltage Electron Microscope.

1975 ◽  
Vol 33 ◽  
pp. 550-551 ◽  
Author(s):  
Brenda R. Eisenberg ◽  
Lee D. Peachey
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
High Voltage ◽  
Sartorius Muscle ◽  
High Voltage Electron Microscopy ◽  
Network Parameters ◽  
Voltage Electron ◽  
High Voltage Electron Microscope ◽  
High Voltage Electron ◽  
T System

Analysis of the electrical properties of the t-system requires knowledge of the geometry of the t-system network. It is now possible to determine the network parameters experimentally by use of high voltage electron microscopy. The t-system was marked with exogenous peroxidase. Conventional methods of electron microscopy were used to fix and embed the sartorius muscle from four frogs. Transverse slices 0.5-1.0 μm thick were viewed at an accelerating voltage of 1000 kV using the JEM-1000 high voltage electron microscope at Boulder, Colorado and prints at x5000 were used for analysis.The length of a t-branch (t) from node to node (Fig. 1a) was measured with a magnifier; at least 150 t-branches around 30 myofibrils were measured from each frog. The mean length of t is 0.90 ± 0.11 μm and the number of branches per myofibril is 5.4 ± 0.2 (mean ± SD, n = 4 frogs).

Immunological mechanisms of chronic liver lesions under the influence of chemicals

2020 ◽  
pp. 536-537
Author(s):  
G. S. Agzamova ◽  
M. M. Abdullaeva
Keyword(s):  
The Body ◽  
Chronic Liver ◽  
Toxic Substances ◽  
Liver Lesions ◽  
Industrial Chemicals ◽  
Toxic Agent ◽  
Chronic Poisoning ◽  
Immunological Mechanisms ◽  
T System

The immunological profile of chronic liver lesions depending on the toxic agent was studied. It was revealed that chronic poisoning by industrial toxic substances causes changes in the functional state of the T-system of immunity, long-term contact with industrial chemicals leads to increased sensitization to autoantigens of the body.

scholarly journals Model-Based Analysis of the Link between Groundwater Table Rising and the Formation of Solute Plumes in a Shallow Stratified Aquifer

Pollutants ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 66-86
Author(s):  
Simone Varisco ◽  
Giovanni Pietro Beretta ◽  
Luca Raffaelli ◽  
Paola Raimondi ◽  
Daniele Pedretti
Keyword(s):  
Water Table ◽  
Cost Effective ◽  
Groundwater Table ◽  
Monitoring Wells ◽  
Modeling Analysis ◽  
Contaminant Sources ◽  
Simultaneous Decrease ◽  
Pumping Rates ◽  
Agricultural Areas ◽  
T System

Groundwater table rising (GTR) represents a well-known issue that affects several urban and agricultural areas of the world. This work addresses the link between GTR and the formation of solute plumes from contaminant sources that are located in the vadose zone, and that water table rising may help mobilize with time. A case study is analyzed in the stratified pyroclastic-alluvial aquifer near Naples (Italy), which is notoriously affected by GTR. A dismissed chemical factory generated a solute plume, which was hydraulically confined by a pump-and-treat (P&T) system. Since 2011, aqueous concentrations of 1,1-dichloroethene (1,1-DCE) have been found to exceed regulatory maximum concentration levels in monitoring wells. It has been hypothesized that a 1,1-DCE source may occur as buried waste that has been flushed with time under GTR. To elucidate this hypothesis and reoptimize the P&T system, flow and transport numerical modeling analysis was developed using site-specific data. The results indicated that the formulated hypothesis is indeed plausible. The model shows that water table peaks were reached in 2011 and 2017, which agree with the 1,1-DCE concentration peaks observed in the site. The model was also able to capture the simultaneous decrease in the water table levels and concentrations between 2011 and 2014. Scenario-based analysis suggests that lowering the water table below the elevation of the hypothesized source is potentially a cost-effective strategy to reschedule the pumping rates of the P&T system.

scholarly journals Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yankun Lyu ◽  
Vipin K. Verma ◽  
Younjee Lee ◽  
Iosif Taleb ◽  
Rachit Badolia ◽  
...  
Keyword(s):  
Heart Function ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
Excitation Contraction Coupling ◽  
Transverse Tubular System ◽  
Contraction Coupling ◽  
Senescent Phenotype ◽  
Cellular Microstructure ◽  
T System

AbstractIt is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and their differences to chronic heart failure (HF) associated remodeling remain ill-defined. Here, we show that the transverse tubular system (t-system) and proteins underlying excitation-contraction coupling in cardiomyocytes are characteristically remodeled with age. We shed light on mechanisms of this remodeling and identified similarities and differences to chronic HF. Using left ventricular myocardium from donors and HF patients with ages between 19 and 75 years, we established a library of 3D reconstructions of the t-system as well as ryanodine receptor (RyR) and junctophilin 2 (JPH2) clusters. Aging was characterized by t-system alterations and sarcolemmal dissociation of RyR clusters. This remodeling was less pronounced than in HF and accompanied by major alterations of JPH2 arrangement. Our study indicates that targeting sarcolemmal association of JPH2 might ameliorate age-associated deficiencies of heart function.

A techno-economic analysis for an integrated solar PV/T system with thermal and electrical storage — Case study

2015 ◽  
Author(s):  
A. U. C. D. Athukorala ◽  
W. J. A. Jayasuriya ◽  
S. Ragulageethan ◽  
M. P. G. Sirimanna ◽  
R. A. Attalage ◽  
...  
Keyword(s):  
Economic Analysis ◽  
Solar Pv ◽  
T System

A Review on the Heat Pipe Photovoltaic/Thermal (PV/T) System

2021 ◽  
Author(s):  
Jinzhi Zhou ◽  
Wei Zhong ◽  
Dan Wu ◽  
Yanping Yuan ◽  
Wenhui Ji ◽  
...  
Keyword(s):  
Heat Pipe ◽  
T System

scholarly journals Pseudo-T-system in frog and chicken cardiac muscle

1975 ◽  
Vol 25 ◽  
pp. 178-179
Author(s):  
Toshio Kitazawa ◽  
Yoshiaki Nonomura
Keyword(s):  
Cardiac Muscle ◽  
T System

scholarly journals Design and Fabrication of Absorptive/Reflective Crossed CPC PV/T System

Designs ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 29
Author(s):  
Muhsin Aykapadathu ◽  
Mehdi Nazarinia ◽  
Nazmi Sellami
Keyword(s):  
Numerical Control ◽  
Solar Concentrator ◽  
Cnc Milling ◽  
Acceptance Angle ◽  
Optical Efficiency ◽  
Compound Parabolic Concentrator ◽  
Building Integrated Photovoltaic ◽  
New Generation ◽  
Experimental Rig ◽  
T System

A crossed compound parabolic concentrator (CCPC) is a non-imaging concentrator which is a modified form of a circular 3D compound parabolic concentrator (CPC) obtained by orthogonal intersection of two 2D CPCs that have an optical efficiency in line with that of 3D CPC. The present work is about the design and fabrication of a new generation of solar concentrator: the hybrid photovoltaic (PV)/thermal absorptive/reflective CCPC module. The module has a 4× CCPC structure truncated to have a concentration of 3.6× with a half acceptance angle of 30°. Furthermore, an experimental rig was also fabricated to test the performance of the module and its feasibility in real applications such as building-integrated photovoltaic (BIPV). 3D printing and Computer Numerical Control (CNC) milling technologies were utilized to manufacture the absorber and reflective parts of the module.

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