Progress and possibilities for patient-derived iPSCs and genetically engineered stem cells in cancer modeling and targeted therapies

2022 ◽  
pp. 247-288
Author(s):  
Lon Kai Pang ◽  
Mo-Fan Huang ◽  
Julian A. Gingold ◽  
Mezthly Pena ◽  
Ruiying Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Targeted Therapies ◽  
Genetically Engineered ◽  
Cancer Modeling

Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to be Aware of.

2020 ◽  
Vol 21 ◽  
Author(s):  
Mohammad Saeedi ◽  
Muhammad Sadeqi Nezhad ◽  
Fatemeh Mehranfar ◽  
Mahdieh Golpour ◽  
Mohammad Ali Esakandari ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Cells ◽  
Immune Modulation ◽  
Adult Stem Cells ◽  
Inflammatory Diseases ◽  
High Capacity ◽  
Genetically Engineered ◽  
Cartilage Cells ◽  
Biological Aspects

: Mesenchymal stem cells (MSCs), a form of adult stem cells, are known to have a self-renewing property and the potential to specialize into a multitude of cells and tissues such as adipocytes, cartilage cells, and fibroblasts. MSCs can migrate and home to the desired target zone where inflammation is present. The unique characteristics of MSCs in repairing, differentiation, regeneration, and its high capacity of immune modulation has attracted tremendous attention for exerting them in clinical purposes, as they contribute to tissue regeneration process and anti-tumor activity. The MSCs-based treatment has demonstrated remarkable applicability towards various diseases such as heart and bone malignancies, and cancer cells. Importantly, genetically engineered MSCs, as a state-of-the-art therapeutic approach, could address some clinical hurdles by systemic secretion of cytokines and other agents with a short half-life and high toxicity. Therefore, understanding the biological aspects and the characteristics of MSCs is an imperative issue of concern. Herein, we provide an overview of the therapeutic application and the biological features of MSCs against different inflammatory diseases and cancer cells. We further shed light on MSCs physiological interaction, such as migration, homing, and tissue repairing mechanisms with different healthy and inflamed tissues.

scholarly journals Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Monika Raab ◽  
Sven Kappel ◽  
Andrea Krämer ◽  
Mourad Sanhaji ◽  
Yves Matthess ◽  
...  
Keyword(s):  
Targeted Therapies ◽  
Mammalian Cells ◽  
Genetically Engineered ◽  
Genetically Engineered Mice

Automated sorting of genetically engineered embryonic stem cells for generation of mouse models

2007 ◽  
Vol 4 (1) ◽  
pp. v-vi
Author(s):  
Gunther Kauselmann ◽  
Heidrun Kern ◽  
Anne Klein-Vehne ◽  
Torsten Müller ◽  
Annette Pfennig ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Mouse Models ◽  
Embryonic Stem ◽  
Genetically Engineered

scholarly journals Could Cells from Your Nose Fix Your Heart? Transplantation of Olfactory Stem Cells in a Rat Model of Cardiac Infarction

2010 ◽  
Vol 10 ◽  
pp. 422-433 ◽  
Author(s):  
Cameron McDonald ◽  
Alan Mackay-Sim ◽  
Denis Crane ◽  
Wayne Murrell
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Fluorescent Protein ◽  
Genetically Engineered ◽  
Olfactory Mucosa ◽  
Cell Transplant ◽  
Adult Rat ◽  
Cardiac Ventricle ◽  
Green Fluorescent

This study examines the hypothesis that multipotent olfactory mucosal stem cells could provide a basis for the development of autologous cell transplant therapy for the treatment of heart attack. In humans, these cells are easily obtained by simple biopsy. Neural stem cells from the olfactory mucosa are multipotent, with the capacity to differentiate into developmental fates other than neurons and glia, with evidence of cardiomyocyte differentiationin vitroand after transplantation into the chick embryo. Olfactory stem cells were grown from rat olfactory mucosa. These cells are propagated as neurosphere cultures, similar to other neural stem cells. Olfactory neurospheres were grownin vitro, dissociated into single cell suspensions, and transplanted into the infarcted hearts of congeneic rats. Transplanted cells were genetically engineered to express green fluorescent protein (GFP) in order to allow them to be identified after transplantation. Functional assessment was attempted using echocardiography in three groups of rats: control, unoperated; infarct only; infarcted and transplanted. Transplantation of neurosphere-derived cells from adult rat olfactory mucosa appeared to restore heart rate with other trends towards improvement in other measures of ventricular function indicated. Importantly, donor-derived cells engrafted in the transplanted cardiac ventricle and expressed cardiac contractile proteins.

scholarly journals The evolution of cancer modeling: the shadow of stem cells

2010 ◽  
Vol 3 (3-4) ◽  
pp. 149-155 ◽  
Author(s):  
C. Vicente-Duenas ◽  
C. Cobaleda ◽  
J. Perez-Losada ◽  
I. Sanchez-Garcia
Keyword(s):  
Stem Cells ◽  
Cancer Modeling

scholarly journals Genetically engineered suicide gene in mesenchymal stem cells using a Tet-On system for anaplastic thyroid cancer

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181318 ◽  
Author(s):  
Senthilkumar Kalimuthu ◽  
Ji Min Oh ◽  
Prakash Gangadaran ◽  
Liya Zhu ◽  
Ho Won Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Thyroid Cancer ◽  
Suicide Gene ◽  
Anaplastic Thyroid Cancer ◽  
Genetically Engineered

scholarly journals Therapeutic effect of genetically engineered mesenchymal stem cells in rat experimental leptomeningeal glioma model

2010 ◽  
Vol 291 (2) ◽  
pp. 256-262 ◽  
Author(s):  
Chunyu Gu ◽  
Shaoyi Li ◽  
Tsutomu Tokuyama ◽  
Naoki Yokota ◽  
Hiroki Namba
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effect ◽  
Genetically Engineered ◽  
Glioma Model
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