Hybrid advanced control of flexible multipurpose continuous tablet manufacturing process via direct compaction

Author(s):  
Ravendra Singh ◽  
Marianthi Ierapetritou ◽  
Rohit Ramachandran
2019 ◽  
Vol 354 ◽  
pp. 199-210 ◽  
Author(s):  
S.C. Galbraith ◽  
B. Cha ◽  
Z. Huang ◽  
S. Park ◽  
H. Liu ◽  
...  

2014 ◽  
Vol 71 ◽  
pp. 130-140 ◽  
Author(s):  
Emmanuela Gavi ◽  
Gavin K. Reynolds

Processes ◽  
2015 ◽  
Vol 3 (2) ◽  
pp. 339-356 ◽  
Author(s):  
Ravendra Singh ◽  
Fernando Muzzio ◽  
Marianthi Ierapetritou ◽  
Rohit Ramachandran

2017 ◽  
Vol 5 ◽  
pp. 86-93
Author(s):  
Izabela Dagmara Czabak-Górska

Control Charts are the basic tool for quality control. They were developed in the 1920s when the dominant type of production was mass production. In order to properly use classic Control Charts, the data from the manufacturing process should meet the following assumptions: an empirical distribution of measurement data should be normally distributed or close to a normal distribution, measurement data should be independent, the manufacturing process should be capable of quality depending on the type of Control Chart, a sample that is large enough (sometimes made of several elements) must be taken. Currently, a shift can be observed from mass production towards short production runs, which causes the proper use of the traditional approach to be impossible. In recent years, control charts are once again in the spotlight, and consequently many scientists, i.e. Reynolds, Zimmer, Costa, Calvin and Chan have undertaken the task to adapt the classic idea of keeping Control Charts to modern conditions of production. The development of science in this area allows for the avoidance of making major mistakes in the conduct of Control Charts and for making the wrong decisions based on erroneous analysis. However, the appearance of new literature pieces implies the need to classify Control Charts, therefore, this article describes the idea of conduct, the most important assumptions and distribution of classical Shewhart's Control Charts, as well as a suggestion for the distribution of advanced Control Charts that meet the needs of the currently used production types. The work also contains a concise description of the chosen control charts as well as the threats resulting from their inappropriate selection. This elaboration is an extension to the article of Czabak-Górska (2017).


2015 ◽  
Vol 1 (4) ◽  
pp. 179
Author(s):  
Brahmaiah Bonthagarala ◽  
Sandhya Ch. ◽  
Pusuluri Dharani Lakshmi Sai ◽  
Konkipudi Venkata Sivaiah

The purpose of this work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process with special reference to the requirements stipulated by the US Food and Drug Administration (FDA).Quality is always an imperative prerequisite when we consider any product. Therefore, drugs must be manufactured to the highest quality levels. End-product testing by itself does not guarantee the quality of the product. Quality assurance techniques must be used to build the quality into the product at every step and not just tested for at the end. In pharmaceutical industry, Process Validation performs this task to build the quality into the product because according to ISO 9000:2000, it had proven to be an important tool for quality management of pharmaceuticals.


RSC Advances ◽  
2021 ◽  
Vol 11 (14) ◽  
pp. 8323-8345
Author(s):  
Guolin Shi ◽  
Longfei Lin ◽  
Yuling Liu ◽  
Gongsen Chen ◽  
Yuting Luo ◽  
...  

Multivariate modeling techniques play important roles in the tablet manufacturing process.


2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Nadya Nurul Zaman ◽  
Iyan Sopyan

Rute pemberian obat secara oral sangat disukai oleh sebagian besar pengguna. Salah satu bentuk sediaan oral yang paling disukai adalah tablet. Tablet merupakan bentuk sediaan padat yang mengandung bahan aktif dengan atau tanpa bahan pengisi. Metode dalam penulisan review artikel ini adalah studi pustaka secara elektronik dengan mengakses situs pencarian jurnal internasional dan nasional yang memenuhi kriteria inklusi. Pada review artikel ini akan dibahas mengenai metode umum pembuatan tablet, yaitu terdapat tiga metode diantaranya metode granulasi basah, metode granulasi kering dan metode kempa langsung, serta kemungkinan - kemungkinan masalah umum terjadinya kecacatan fisik tablet yang sering ditemui bersama dengan penyebabnya dan cara mengatasi sumber masalah tersebut. Selama proses pembuatan, penyimpanan dan pendistribusian tablet sering kali ditemui masalah kerusakan fisik tablet seperti capping, lamination, cracking, chipping, sticking, picking, binding, mottling dan double impression, yang dapat mengurangi penerimaan oleh pengguna dan keefektifan fungsional sediaan.Kata kunci: Tablet, Metode Pembuatan Tablet, Masalah Umum Kerusakan Tablet.


2014 ◽  
Vol 9 (1) ◽  
pp. 16-37 ◽  
Author(s):  
Ravendra Singh ◽  
Dana Barrasso ◽  
Anwesha Chaudhury ◽  
Maitraye Sen ◽  
Marianthi Ierapetritou ◽  
...  

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