scholarly journals Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets

RSC Advances ◽  
2021 ◽  
Vol 11 (14) ◽  
pp. 8323-8345
Author(s):  
Guolin Shi ◽  
Longfei Lin ◽  
Yuling Liu ◽  
Gongsen Chen ◽  
Yuting Luo ◽  
...  

Multivariate modeling techniques play important roles in the tablet manufacturing process.

2019 ◽  
Vol 354 ◽  
pp. 199-210 ◽  
Author(s):  
S.C. Galbraith ◽  
B. Cha ◽  
Z. Huang ◽  
S. Park ◽  
H. Liu ◽  
...  

Author(s):  
John Martin

The pilger process is a cold-worked mechanical process that combines the elements of extrusion, rolling, and upsetting for the formation of thin-walled tubes. This complex manufacturing process relies on the results of trial and error testing programs, experimental parameter sensitivity studies, and prototypical applications to advance the technology. This finite element modelling effort describes the methods, models, and assumptions used to assess the process parameters used to manufacture thin-walled tubing. The modelling technique breaks down the manufacturing process into smaller computer generated models representing fundamental process functions. Each of these models is linked with the overall process simulation. Simplified assumptions are identified and supporting justifications provided. This work represents proof of principle modelling techniques, using large deformation, large strain, finite element software. These modelling techniques can be extended to more extensive parameter studies evaluating the effects of pilger process parameter changes on final tube stress and strain states and their relationship to defect formation/propagation. Sensitivity studies on input variables and the process parameters associated with one pass of the pilger process are also included. The modelling techniques have been extended to parameter studies evaluating the effects of pilger process parameter changes on tube stress and strain states and their relationship to defect formation. Eventually a complex qualified 3-D model will provide more accurate results for process evaluation purposes. However, the trends and results reported are judged adequate for examining process trends and parameter variability.


Author(s):  
N. Boylan ◽  
C. Gaudin ◽  
D. J. White ◽  
M. F. Randolph ◽  
J. A. Schneider

The gradual shift of hydrocarbon developments into deeper waters has presented fresh challenges for offshore geotechnical engineering. Many installations in deep water require export pipelines to shore which can be many hundreds of kilometers in length. These pipelines must negotiate unstable regions of soft seabed around the steep continental shelf and variable terrain including canyons with depths ranging from tens of meters to a several hundred meters. These challenging conditions present potential geohazards for which little understanding has been developed so far. One of the major geohazards is the impact of a submarine landslide on nearby pipelines which could potentially damage the pipeline. Consequently, a Joint Industry Project (JIP) has been initiated at the Centre for Offshore Foundation Systems to improve methods for assessing the potential damage to pipelines and to provide information to assist re-routing of a pipeline to a safer alignment if necessary. This paper presents an overview of the development of specific modeling techniques to (i) trigger a submarine landslide in a geotechnical centrifuge, (ii) measure the strength properties of the slide material before, during, and after the slide failure and (iii) measure the interaction between the runout material and the seabed.


2014 ◽  
Vol 71 ◽  
pp. 130-140 ◽  
Author(s):  
Emmanuela Gavi ◽  
Gavin K. Reynolds

Processes ◽  
2015 ◽  
Vol 3 (2) ◽  
pp. 339-356 ◽  
Author(s):  
Ravendra Singh ◽  
Fernando Muzzio ◽  
Marianthi Ierapetritou ◽  
Rohit Ramachandran

TRANSFORMATIF ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 374
Author(s):  
Muhammad Wildan Romdhoni ◽  
Nurul Faizah

<p>This research is motivated by the inequality of character development of students, particularly confidence when speaking in public. This study aims to answer the problem formulation which is reflected in the research hypothesis that modelling techniques effective in increasing the confidence of students in Pondok Pesantren Assalafi Al-Fithrah Surabaya (H<sub>a</sub>). The approach used is a quantitative approach with the research methods true experimental design, pretest-posttest control group design. Samples were taken by purposive from the population are students of class Isti'dad Ulya  A and B. The results of data analysis showed that the modeling techniques effective in improving students confidence when speaking in public in Pondok Pesantren Assalafi Al-Fithrah Surabaya.</p><p class="Abstract"><strong>Keywords</strong>: Modeling Techniques, Self Confidence</p>


Sign in / Sign up

Export Citation Format

Share Document