CONTROLLED RELEASE OF INSULIN FROM BORONIC ACID GEL UNDER PHYSIOLOGICAL CONDITIONS

Over the past years, many scientific researches have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer. The NIPAM based hydrogels with 20 mol% 2-hydroxypropyl methacrylate (HPMet) were synthesized using ethylene glycol dimethacrylate as a cross-linker. The characterization of xerogel and phenacetin using FTIR spectra and SEM micrographs confirm the performed synthesis with satisfactory purity as well as loading of phenacetin into hydrogel. The swelling transport mechanism at simulated physiological conditions (pH 2.20 and 7.40 at 37?C) is described by the time-independent kinetics. The potential application of synthesized hydrogels for the controlled release of phenacetin as a model drug was investigated at simulated physiological conditions by HPLC method.

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Highly sensitive detection of saccharides under physiological conditions with click synthesized boronic acid-oligomer fluorophores

Organic & Biomolecular Chemistry ◽

10.1039/c0ob01003k ◽

2011 ◽

Vol 9 (5) ◽

pp. 1332 ◽

Cited By ~ 20

Author(s):

Karimulla Mulla ◽

Prateek Dongare ◽

Ningzhang Zhou ◽

Guang Chen ◽

David W. Thompson ◽

...

Keyword(s):

Boronic Acid ◽

Sensitive Detection ◽

Physiological Conditions ◽

Highly Sensitive ◽

Highly Sensitive Detection

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Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions

Polymers ◽

10.3390/polym10101164 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1164 ◽

Cited By ~ 6

Author(s):

Kentaro Yoshida ◽

Kazuma Awaji ◽

Seira Shimizu ◽

Miku Iwasaki ◽

Yuki Oide ◽

...

Keyword(s):

Boronic Acid ◽

Oxidation Reaction ◽

Shikimic Acid ◽

Multilayer Films ◽

Electrostatic Repulsion ◽

Layer By Layer ◽

Sensitive Layer ◽

Boronate Ester ◽

Physiological Conditions ◽

Phenyl Boronic Acid

Hydrogen peroxide (H2O2)-sensitive layer-by-layer films were prepared based on combining phenyl boronic acid (PBA)-modified poly(allylamine) (PAH) with shikimic acid (SA)-modified-PAH through boronate ester bonds. These PBA-PAH/SA-PAH multilayer films could be prepared in aqueous solutions at pH 7.4 and 9.0 in the presence of NaCl. It is believed that the electrostatic repulsion between the SA-PAH and PBA-PAH was diminished and the formation of ester bonds between the SA and PBA was promoted in the presence of NaCl. These films readily decomposed in the presence of H2O2 because the boronate ester bonds were cleaved by an oxidation reaction. In addition, SA-PAH/PBA-PAH multilayer films combined with glucose oxidase (GOx) were decomposed in the presence of glucose because GOx catalyzes the oxidation of D-glucose to generate H2O2. The surfaces of CaCO3 microparticles were coated with PAH/GOx/(SA-PAH/PBA-PAH)5 films that absorbed insulin. A 1 mg quantity of these particles released up to 10 μg insulin in the presence 10 mM glucose under physiological conditions.

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