Developing crash modification functions for pedestrian signal improvement

2015 ◽  
Vol 83 ◽  
pp. 47-56 ◽  
Author(s):  
Emanuele Sacchi ◽  
Tarek Sayed ◽  
Ahmed Osama
Keyword(s):  
Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 491
Author(s):  
Sona Jain ◽  
Wanessa Santana ◽  
Silvio S. Dolabella ◽  
André L. S. Santos ◽  
Eliana B. Souto ◽  
...  

Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12–15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed.


Lab on a Chip ◽  
2016 ◽  
Vol 16 (18) ◽  
pp. 3460-3465 ◽  
Author(s):  
Biao Ma ◽  
Yi-Zhen Song ◽  
Ji-Cheng Niu ◽  
Zhi-Yong Wu

Electrokinetic stacking based on field amplification was firstly introduced to a paper-based analytical device, and over 1000-fold signal improvement was achieved.


Bioanalysis ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 465-479
Author(s):  
Lijuan Kang ◽  
Shengsheng Xu ◽  
Yongle Pang ◽  
Tom Kirchner ◽  
Yue-mei Zhang ◽  
...  

Aim: To further enhance the detection sensitivity and increase resolving power of top-down intact protein bioanalysis, middle-down approach was explored. Materials & methods: An monoclonal antibody (mAb) was used as a model protein to evaluate quantitative bioanalytical assay performance and a disulfide linked dimer protein was investigated for its pharmacokinetics properties and catabolism in vivo by middle-down approach. Results & Conclusion: For quantitation of the mAb, different subunits generated by middle-down approach provided different level of signal improvement in biological samples with Lc and half Fc giving five-times better sensitivity than intact mAb. For the dimer protein, middle-down analysis by reduction enabled effective differentiation of the unchanged protein and its oxidized form, and clearly elucidated their respective proteolytic catabolites.


2018 ◽  
Vol 49 (14) ◽  
pp. 2389-2396 ◽  
Author(s):  
J. Stochl ◽  
E. Soneson ◽  
A.P. Wagner ◽  
G.M. Khandaker ◽  
I. Goodyer ◽  
...  

AbstractBackgroundAn increasing importance is being placed on mental health and wellbeing at individual and population levels. While there are several interventions that have been proposed to improve wellbeing, more evidence is needed to understand which aspects of wellbeing are most influential. This study aimed to identify key items that signal improvement of mental health and wellbeing.MethodsUsing network analysis, we identified the most central items in the graph network estimated from the well-established Warwick-Edinburgh Mental Well-being Scale (WEMWBS). Results were compared across four major UK cohorts comprising a total of 47,578 individuals: the Neuroscience in Psychiatry Network, the Scottish Schools Adolescent Lifestyle and Substance Use Survey, the Northern Ireland Health Survey, and the National Child Development Study.ResultsRegardless of gender, the three items most central in the network were related to positive self-perception and mood: ‘I have been feeling good about myself’; ‘I have been feeling confident’; and ‘I have been feeling cheerful’. Results were consistent across all four cohorts.ConclusionsPositive self-perception and positive mood are central to psychological wellbeing. Psychotherapeutic and public mental health interventions might best promote psychological wellbeing by prioritising the improvement of self-esteem, self-confidence and cheerfulness. However, empirical testing of interventions using these key targets is needed.


Nanomaterials ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 97 ◽  
Author(s):  
Chong-You Chen ◽  
Chia-Lin Chen ◽  
Chang-Ming Wang ◽  
Wei-Ssu Liao

2020 ◽  
Vol 20 (Special1) ◽  
pp. 128-137
Author(s):  
Rosalam CM ◽  
Faisul AA ◽  
Ruhaizin S ◽  
Khairul MK ◽  
Hassan A ◽  
...  

Age is typically affiliated with the decline of cognitive function and the probability to be diagnosed with neurodegenerative disease, namely dementia. Of all dementia-related deficits, the paper highlights on the decline of wayfinding ability, since it is interrelated with mobility, autonomy, caregiving burden and eventually institutionalization. The sense of directions in elderly is also affected by the sensory changes, while the most obvious sensory declines are both vision and hearing. Hence navigation systems that support mainly on visual and auditory may not be the best option for them. A concept of wearable navigational assistance that is non-intrusive and uses haptic stimuli instead of visual and/or audio signals is presented in this paper. A Usability Test (UT) was performed towards the elderly with dementia at a selected nursing home to investigate how they perceive haptic-feedback as a modality of navigation. The assessments involved three phases: (1) orientation or training, (2) navigation test and (3) further navigation test. Results indicate the potential efficacy of haptic modality as a navigation signal. Improvement on subjects’ navigational performance was shown especially during the further navigation test, signifying the familiarization of the intervention. Employing the haptic modality could be a beneficial substitute for navigational purpose when vision and audio are less appropriate. Nevertheless, as much as the encouraging outcomes from the results and analysis of the assessments are valuable, the constructive reviews attained are indeed important for the future development of the device system.


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