Paper-based electrochemical cyto-device for sensitive detection of cancer cells and in situ anticancer drug screening

2014 ◽  
Vol 847 ◽  
pp. 1-9 ◽  
Author(s):  
Min Su ◽  
Lei Ge ◽  
Shenguang Ge ◽  
Nianqiang Li ◽  
Jinghua Yu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Drug Screening ◽  
Sensitive Detection

Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening

Biomaterials ◽  
2013 ◽  
Vol 34 (29) ◽  
pp. 7117-7126 ◽  
Author(s):  
Limin Zhang ◽  
Liming Wang ◽  
Yili Hu ◽  
Zhigang Liu ◽  
Yuan Tian ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Gold Nanorods ◽  
Drug Screening ◽  
Metabolic Effects

In Situ formation of pH-/thermo-sensitive nanohybrids via friendly-assembly of poly(N-vinylpyrrolidone) onto LAPONITE®

RSC Advances ◽  
2016 ◽  
Vol 6 (38) ◽  
pp. 31816-31823 ◽  
Author(s):  
Jin'e Wang ◽  
Guoying Wang ◽  
Yi Sun ◽  
Yifeng Wang ◽  
Yang Yang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drug ◽  
Ph Sensitive ◽  
High Efficacy ◽  
Effective Delivery ◽  
In Situ Formation ◽  
Ph Sensitive Polymer

Decoration of silicate nanodisks with a pH-sensitive polymer allows for the effective delivery of an anticancer drug in cancer cells with high efficacy.

A Perfused Two-Chamber System for Anticancer Drug Screening

2010 ◽  
Author(s):  
Liang Ma ◽  
Jeremy Barker ◽  
Changchun Zhou ◽  
Biaoyang Lin ◽  
Wei Li
Keyword(s):  
Cell Culture ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Drug Screening ◽  
Culture System ◽  
Liver Cells ◽  
Cell Culture System ◽  
Chamber System ◽  
A Cell

A cell culture microfluidic device has been developed to test the cytotoxicity of anticancer drugs while reproducing multi-organ interactions in vitro. Cells were cultured in separate chambers representing the liver and tumor. The two chambers were connected through a channel to mimick the blood flow. Glioblastoma (GBM) cancer cells (M059K) and hepatoma cells (HepG2) were cultured in the tumor and the liver chambers, respectively. The cytotoxic effect of cancer treatment drug Temolozomide (TMZ) was tested using this two chamber system. The experimental results showed that with the liver cells, the cancer cells showed much higher viability than those without the liver cells. This indicates that the liver metabolism has strong effect on the toxicity of the anticancer drug. The results demonstrated that the perfused two chamber cell culture system has the potential to be used as a platform for drug screening in a more physiologically realistic environment.

On-chip anticancer drug screening – Recent progress in microfluidic platforms to address challenges in chemotherapy

2019 ◽  
Vol 137 ◽  
pp. 236-254 ◽  
Author(s):  
Nandini Dhiman ◽  
Peter Kingshott ◽  
Huseyin Sumer ◽  
Chandra S. Sharma ◽  
Subha Narayan Rath
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Recent Progress ◽  
Microfluidic Platforms ◽  
On Chip
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