In Situ formation of pH-/thermo-sensitive nanohybrids via friendly-assembly of poly(N-vinylpyrrolidone) onto LAPONITE®

Decoration of silicate nanodisks with a pH-sensitive polymer allows for the effective delivery of an anticancer drug in cancer cells with high efficacy.

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Electrochemical detection of telomerase in cancer cells based on the in-situ formation of streptavidin-biotin-DNA-biotin networks for signal amplification

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2021.129659 ◽

2021 ◽

Vol 334 ◽

pp. 129659

Author(s):

Lin Liu ◽

Daohong Wu ◽

Shuang Zhen ◽

Kaiqing Lu ◽

Xinyao Yi ◽

...

Keyword(s):

Cancer Cells ◽

Electrochemical Detection ◽

Signal Amplification ◽

In Situ Formation

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In situ synthesized BSA capped gold nanoparticles: Effective carrier of anticancer drug Methotrexate to MCF-7 breast cancer cells

Materials Science and Engineering C ◽

10.1016/j.msec.2013.09.004 ◽

2014 ◽

Vol 34 ◽

pp. 158-167 ◽

Cited By ~ 52

Author(s):

Priyanka Murawala ◽

Amruta Tirmale ◽

Anjali Shiras ◽

B.L.V. Prasad

Keyword(s):

Breast Cancer ◽

Gold Nanoparticles ◽

Cancer Cells ◽

Anticancer Drug ◽

Breast Cancer Cells ◽

Effective Carrier ◽

Mcf 7

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Construction and evaluation of pH-sensitive immunoliposomes for enhanced delivery of anticancer drug to ErbB2 over-expressing breast cancer cells

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2016.11.018 ◽

2017 ◽

Vol 13 (3) ◽

pp. 1219-1227 ◽

Cited By ~ 19

Author(s):

Tianshu Li ◽

Takuya Amari ◽

Kentaro Semba ◽

Tadashi Yamamoto ◽

Shinji Takeoka

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Anticancer Drug ◽

Breast Cancer Cells ◽

Ph Sensitive

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Enzyme-mediated in situ formation of pH-sensitive nanogels for proteins delivery

RSC Advances ◽

10.1039/c5ra25133h ◽

2016 ◽

Vol 6 (10) ◽

pp. 8032-8042 ◽

Cited By ~ 17

Author(s):

Zhipeng Zeng ◽

Yingqi She ◽

Zhiping Peng ◽

Junchao Wei ◽

Xiaohui He

Keyword(s):

Protein Delivery ◽

Ph Sensitive ◽

Crosslinking Reaction ◽

Intracellular Protein ◽

In Situ Formation ◽

Intracellular Protein Delivery

pH-Sensitive (PEG-b-P(LGA-g-Tyr)) nanogels were fabricated through the enzyme-mediated crosslinking reaction and used to load FITC-BSA for intracellular protein delivery.

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A Facile Strategy for In Situ Controlled Delivery of Doxorubicin with a pH-Sensitive Injectable Hydrogel

Nano LIFE ◽

10.1142/s1793984414410013 ◽

2014 ◽

Vol 04 (03) ◽

pp. 1441001 ◽

Cited By ~ 11

Author(s):

Jun Chen ◽

Xiaojian Li ◽

Liqian Gao ◽

Yi Hu ◽

Wen Zhong ◽

...

Keyword(s):

Ph Sensitive ◽

Controlled Delivery ◽

Cell Uptake ◽

Injectable Hydrogel ◽

Poorly Soluble ◽

Poly Ethylene ◽

Novel Strategy ◽

Ph Sensitive Polymer ◽

Tunable Stiffness

In light of the challenges along with the traditional intravenous administration of chemotherapeutics, injectable hydrogel-drug system emerges as a powerful tool for noninvasive and in situ controlled-release of drugs. Herein, we report a novel strategy of drug delivery system with pH responsive injectable hydrogels by taking advantages of two biomaterials. The first one is a pH sensitive polymer-drug (prodrug) conjugate, poly (ethylene glycol)–doxorubicin (MPEG–DOX) with hydrazone linkage. This prodrug interacted with a second biomaterial, α-cyclodextrin (α-CD) under mild conditions and subsequently formed the hydrogels in minutes with tunable stiffness. The gels showed a sustained release behavior dependent on the surrounding pH and released drugs effectively killed tumor cells (MCF-7). The quick cell uptake and efficient intracellular delivery of DOX were observed under a confocal microscope. This study thus provides a novel and simple drug encapsulation strategy to deliver poorly soluble drugs in situ for a potential targeted chemotherapy.

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