Increased left ventricular mass is a risk factor for the development of a depressed left ventricular ejection fraction within five years. The Cardiovascular Health Study

2004 ◽  
Vol 13 (12) ◽  
pp. 27-28 ◽  
Author(s):  
M.H. Drazner ◽  
J.E. Rame ◽  
E.K. Marino
Keyword(s):  
Risk Factor ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Left Ventricular Mass ◽  
Cardiovascular Health ◽  
Left Ventricular ◽  
Health Study ◽  
Left Ventricular Ejection ◽  
Cardiovascular Health Study ◽  
Ventricular Ejection Fraction

Abstract 9902: Serum FGF23 Concentration is Associated With Cardiac Hypertrophy and Decreased Systolic Function Among Both CKD and Non-CKD Cardiac Patients

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Hideaki Morita ◽  
Shuichi Fujita ◽  
Takahide Ito ◽  
Koichi Sohmiya ◽  
Masaaki Hoshiga ◽  
...  
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Cardiac Hypertrophy ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Cardiac Patients ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Fgf23 Concentration ◽  
Independent Variable

Introduction: Purpose: Serum concentrations of fibroblast growth factor-23 (FGF23) are increased in response to elevated serum phosphate levels among patients with renal dysfunction. Besides regulating circulating phosphate levels, FGF23 may induce cardiac hypertrophy; thus, enhanced FGF23 excretion may underlie the heart failure observed among patients with chronic kidney disease (CKD). Here we examined whether FGF23 concentrations are associated with cardiac hypertrophy among cardiac patients regardless of the presence or absence of CKD. Methods: The present study enrolled 480 cardiac patients admitted to our cardiology department between January 2012 and December 2012. Serum FGF23 level was measured by an ELISA method. Left ventricular mass index (LVMI) was used as a marker of cardiac hypertrophy. Results: Of the 480 patients, 132 (27.5%) had an estimated glomerular filtration rate (eGFR) of <60 mL/min/m2 (no-CKD group) and the remaining 348 (72.5%) had an eGFR of 60 or greater (CKD group). FGF23 was correlated with eGFR in the CKD group, but not in the no-CKD group. Stepwise multivariate linear regression analysis was performed using LVMI as a dependent variable, and sex, age, eGFR, serum calcium and phosphate, and log(FGF23) as independent variables. Log(FGF23) was selected as an independent variable that had a significant association with LVMI with a standardized correlation coefficient of 0.26 in the no-CKD group (P<0.01) and 0.25 in the CKD group (P<0.01). When left ventricular ejection fraction was used as an independent variable in this model, log(FGF23) was selected as significant predictor with a standardized correlation coefficient of -0.20 in the no-CKD group (P<0.05) and -0.18 in the CKD group (P<0.01). Conclusions: Among cardiac patients, serum FGF23 concentration was associated positively with left ventricular mass and negatively with left ventricular ejection fraction not only in patients with CKD, but also in those without CKD.

scholarly journals Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Szu-Chia Chen ◽  
Jer-Ming Chang ◽  
Wan-Chun Liu ◽  
Yi-Chun Tsai ◽  
Jer-Chia Tsai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Left Ventricular Ejection Fraction ◽  
Kidney Disease ◽  
Ejection Fraction ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Diabetic Patients ◽  
Ventricular Ejection Fraction

Aims. Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of chronic kidney disease (CKD).Methods. This cross-sectional study enrolled 285 diabetic patients with CKD stages 3 to 5 from our outpatient department of internal medicine. Clinical and echocardiographic parameters were compared and analyzed.Results. We found a significant stepwise increase in LVMI (P<0.001), LVH (P<0.001), and LVEF<55%(P=0.013) and a stepwise decrease in LVEF (P=0.038) corresponding to advance in CKD stages.Conclusions. Our findings suggest that increases in LVMI and decreases in LVEF coincide with advances in CKD stages in patients with diabetes.

Sign in / Sign up

Export Citation Format

Share Document