Multimodality Imaging With PET/CT and MRI Reveals Hypometabolism in Tertiary Olfactory Cortex in Parosmia of COVID-19

Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, staging, image-guided biopsy, response evaluation after treatment and follow-up. Besides CT and MRI, hybrid imaging including positron emission tomography (PET)/CT and PET/MRI are giving an increasing contribution to provide functional insights about tumour biology and to improve the diagnostic accuracy of the imaging work-up. This review paper provides a revision of the pathology, clinical and radiological features of adult RMS, with a particular focus on the growing role of hybrid PET-based imaging.

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A decade of multi-modality PET and MR imaging in abdominal oncology

British Journal of Radiology ◽

10.1259/bjr.20201351 ◽

2021 ◽

pp. 20201351

Author(s):

Lisa A. Min ◽

Francesca Castagnoli ◽

Wouter V. Vogel ◽

Jisk P. Vellenga ◽

Joost J.M. van Griethuysen ◽

...

Keyword(s):

Mr Imaging ◽

Multimodality Imaging ◽

Predictive Biomarkers ◽

Mri Imaging ◽

Similar Time ◽

Institutional Data ◽

Pet Tracer ◽

Pet Ct ◽

Published Research ◽

Ct And Mri

Objectives: To investigate trends observed in a decade of published research on multimodality PET(/CT)+MR imaging in abdominal oncology, and to explore how these trends are reflected by the use of multimodality imaging performed at our institution. Methods: First, we performed a literature search (2009–2018) including all papers published on the multimodality combination of PET(/CT) and MRI in abdominal oncology. Retrieved papers were categorized according to a structured labelling system, including study design and outcome, cancer and lesion type under investigation and PET-tracer type. Results were analysed using descriptive statistics and evolutions over time were plotted graphically. Second, we performed a descriptive analysis of the numbers of MRI, PET/CT and multimodality PET/CT+MRI combinations (performed within a ≤14 days interval) performed during a similar time span at our institution. Results: Published research papers involving multimodality PET(/CT)+MRI combinations showed an impressive increase in numbers, both for retrospective combinations of PET/CT and MRI, as well as hybrid PET/MRI. Main areas of research included new PET-tracers, visual PET(/CT)+MRI assessment for staging, and (semi-)quantitative analysis of PET-parameters compared to or combined with MRI-parameters as predictive biomarkers. In line with literature, we also observed a vast increase in numbers of multimodality PET/CT+MRI imaging in our institutional data. Conclusions: The tremendous increase in published literature on multimodality imaging, reflected by our institutional data, shows the continuously growing interest in comprehensive multivariable imaging evaluations to guide oncological practice. Advances in knowledge: The role of multimodality imaging in oncology is rapidly evolving. This paper summarizes the main applications and recent developments in multimodality imaging, with a specific focus on the combination of PET+MRI in abdominal oncology.

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Direct comparison of choline PET/CT and MRI in the diagnosis of lymph node metastases in patients with prostate cancer

Medicine ◽

10.1097/md.0000000000013344 ◽

2018 ◽

Vol 97 (50) ◽

pp. e13344 ◽

Cited By ~ 5

Author(s):

Shi-ming Huang ◽

Liang Yin ◽

Jian-lan Yue ◽

Yan-feng Li ◽

Yang Yang ◽

...

Keyword(s):

Prostate Cancer ◽

Lymph Node ◽

Lymph Node Metastases ◽

Choline Pet ◽

Pet Ct ◽

Node Metastases ◽

Ct And Mri

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Isolated Intravascular Prostate Carcinoma Recurrence Confirmed With 18F-Fluciclovine PET/CT and MRI

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000003011 ◽

2020 ◽

Vol 45 (6) ◽

pp. 442-443

Author(s):

Ali Agely ◽

Akash Sharma ◽

Ephraim E. Parent ◽

Anem Nawaz ◽

Manoj K. Jain

Keyword(s):

Prostate Carcinoma ◽

Pet Ct ◽

Ct And Mri

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3D carotid reconstructions: imaging, pathology, algorithms and pipelines

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2015.170 ◽

2015 ◽

Vol 42 (S1) ◽

pp. S37-S37

Author(s):

AR Khan ◽

M Cocker ◽

JD Spence ◽

M Alturkustani ◽

C Currie ◽

...

Keyword(s):

Ex Vivo ◽

Imaging Data ◽

Spatial Reference ◽

Standard Data ◽

Tissue Sections ◽

Saturation Intensity ◽

Plaque Pathology ◽

Pet Ct ◽

Atherosclerosis Imaging ◽

Ct And Mri

Background: Whole-slide scanning of tissue sections spatially informed by imaging studies offers the opportunity to reconstruct specimens for co-registration to 3D imaging data. Digital image analysis algorithms can be designed to analyze and reconstruct such specimens via electronic “pipelines”. Methods: A goal of the Canadian Atherosclerosis Imaging Network (CAIN) is to improve the assessment of carotid atheromatous disease through studies that inform clinical imaging with gold-standard data (plaque pathology). To achieve this, sectioned atheromas are manually annotated and analyzed by electronic algorithm for pathological features of interest. Resulting images are then reassembled in 3D for registration to ultrasound, CT, PET-CT and MRI studies. Results: Carotid endarterectomy specimens were sub-serially sectioned, stained, digitized and annotated manually and by electronic algorithms. Resulting 2D images were successfully rendered, reassembled and analyzed in 3D using ex-vivo micro-CT as a spatial reference. Furthermore, histology quantification using colour deconvolution was found to be preferred over hue-saturation-intensity methods 94.7-100% of the time in a blinded multiple rater study. Conclusion: Automated “pipelines” greatly facilitate 3D reconstruction in comparison to traditional slice-by-slice methods. Transformations spatially guided by pre-existing imaging data is not only faster, but has superior objectivity and fidelity. With embedded annotations, 3D pathology maps become a rich, micron-level, permanent digital pathological database for correlative studies.

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The diagnostic performance of 18 F-FDG PET/CT, CT and MRI in the treatment evaluation of ablation therapy for colorectal liver metastases: A systematic review and meta-analysis

Surgical Oncology ◽

10.1016/j.suronc.2016.12.006 ◽

2017 ◽

Vol 26 (1) ◽

pp. 37-45 ◽

Cited By ~ 11

Author(s):

M. Samim ◽

I.Q. Molenaar ◽

M.F.J. Seesing ◽

P.S.N. van Rossum ◽

M.A.A.J. van den Bosch ◽

...

Keyword(s):

Systematic Review ◽

Liver Metastases ◽

Fdg Pet ◽

Colorectal Liver Metastases ◽

Diagnostic Performance ◽

Meta Analysis ◽

Ablation Therapy ◽

Pet Ct ◽

Fdg Pet Ct ◽

Ct And Mri

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The role of CT, PET-CT, and MRI in ovarian cancer

British Journal of Radiology ◽

10.1259/bjr.20210117 ◽

2021 ◽

Vol 94 (1125) ◽

pp. 20210117

Author(s):

Maurits Peter Engbersen ◽

Willemien Van Driel ◽

Doenja Lambregts ◽

Max Lahaye

Keyword(s):

Ovarian Cancer ◽

Essential Role ◽

Advanced Ovarian Cancer ◽

Emission Tomography ◽

Current Position ◽

Positron Emission ◽

Pet Ct ◽

New Treatment ◽

Ct And Mri

New treatment developments in ovarian cancer have led to a renewed interest in staging advanced ovarian cancer. The treatment of females with ovarian cancer patients has a strong multidisciplinary character with an essential role for the radiologist. This review aims to provide an overview of the current position of CT, positron emission tomography-CT, and MRI in ovarian cancer and how imaging can be used to guide multidisciplinary team discussions.

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Abstract 14789: Multimodality Imaging in Mycobacterium Chimaera Cardiovascular Infections

Circulation ◽

10.1161/circ.142.suppl_3.14789 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Nicholas Y Tan ◽

Alex D Tarabochia ◽

Omar M Abu Saleh ◽

Courtney Bennett

Keyword(s):

Aortic Valve ◽

Prosthetic Valve ◽

Multimodality Imaging ◽

Fluid Collection ◽

Prosthetic Valve Endocarditis ◽

The Other ◽

Aortic Prosthesis ◽

Fdg Uptake ◽

Valve Conduit ◽

Pet Ct

Introduction: Mycobacterium Chimaera (MC) infections following cardiovascular surgery are challenging to diagnose given their insidious presentation. We therefore reviewed the various imaging modalities used to diagnose these infections at Mayo Clinic. Methods: Cases from 01/01/2010-06/01/2020 were identified using electronic medical records. Demographics and clinical history were collected. Imaging studies, including transthoracic echocardiogram (TTE), transesophageal echocardiogram (TEE), positron emission tomography / computed tomography (PET/CT), cardiac CT (CCT), and cardiac magnetic resonance (CMR) were reviewed. Results: A total of 7 patients (85.7% male) were found. 6 underwent aortic valve replacement and 1 received an aortic composite valve conduit. Surgical dates ranged from 01/2010-12/2018. Mean age at presentation was 63.3 years. Mean time from surgery to symptom onset was 28.0 months. All patients underwent TTE and TEE; prosthetic valve endocarditis was identified in 6 cases between both, while CMR established the diagnosis in 1 case. TTE showed prosthetic valve obstruction in 2 cases and an anterior pseudoaneurysm in 1 case. TEE findings included thickened prosthesis and/or vegetations (n=5), thickened posterior root (n=4), and root abscess (n=3). Among the 3 patients who underwent PET/CT, 2 demonstrated increased fluorodeoxyglucose (FDG) uptake around the aortic prosthesis; in addition, 1 had elevated FDG uptake in the myocardium suggesting myocarditis. 1 patient did not have aortic prosthesis FDG uptake. In the 2 patients who had CCT, 1 showed a pseudoaneurysm that prompted suspicion for endocarditis, and the other revealed a fluid collection adjacent to the aortic valve conduit. 2 patients underwent CMR; 1 had aortic prosthesis thickening and patchy areas of myocardial delayed enhancement suspicious for myocarditis, whereas the other showed vegetation and an aortic root abscess. Conclusion: TTE plus TEE successfully identified MC prosthetic valve endocarditis in most cases with TEE having higher specificity. Advanced imaging techniques are helpful to support the diagnosis and assess for myocardial and/or aortic involvement. Combining these modalities is therefore crucial in unveiling this elusive organism.

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